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Cracking the Enigma of Endometriosis
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Cracking the Enigma of Endometriosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: closed (2 October 2023) | Viewed by 4565

Special Issue Editor

Prof. Dr. Sun-Wei Guo

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Guest Editor
1. Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
2. Laboratory of Female Reproductive Endocrine-Related Diseases, Fudan University, Shanghai, China
Interests: endometriosis; adenomyosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometriosis has traditionally been viewed as “enigmatic”, defying optimal treatment. All clinical trials on non-hormonal drugs for endometriosis have failed. What do we know about its pathogenesis and pathophysiology? What are novel compounds that hold therapeutic potential? How can we better diagnose various subtypes of endometriosis? What is the psychological impact of endometriosis?

Given all the above-mentioned questions, we welcome papers on epidemiology, pathogenesis, pathophysiology, imaging diagnostics, surgery, and medical treatment of the endometriosis.

Prof. Dr. Sun-Wei Guo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • diagnosis
  • management
  • pathogenesis
  • pathophysiology
  • surgery

Related Special Issue

Published Papers (2 papers)

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Research

11 pages, 517 KiB  
Article
The Clinical Picture and Fecundity of Primary and Recurrent Ovarian Endometriosis with Family History: A Retrospective Analysis
by Bingning Xu, Li Lin, Yongchao Pan, Pei Chen, Chaoshuang Ye, Li Zhao, Yang Jin, Yong Zhou and Ruijin Wu
J. Clin. Med. 2023, 12(5), 1758; https://doi.org/10.3390/jcm12051758 - 22 Feb 2023
Cited by 3 | Viewed by 1182
Abstract
This study aims to evaluate the role of endometriosis family history on the clinical manifestation and fertility performance of primary and recurrent endometriosis. In total, 312 primary and 323 recurrent endometrioma patients with a histological diagnosis were included in this study. Family history [...] Read more.
This study aims to evaluate the role of endometriosis family history on the clinical manifestation and fertility performance of primary and recurrent endometriosis. In total, 312 primary and 323 recurrent endometrioma patients with a histological diagnosis were included in this study. Family history was significantly correlated with recurrent endometriosis (adjusted OR: 3.52, 95% CI: 1.09–9.46, p = 0.008). Patients with a family history showed a significantly higher proportion of recurrent endometriosis (75.76% vs. 49.50%), higher rASRM scores, higher incidence of severe dysmenorrhea, and severe pelvic pain than the sporadic cases. Recurrent endometrioma showed statistical increase in rASRM scores, percentage of rASRM Stage IV, dysmenorrhea, dyschezia, those undergoing semi-radical surgery or unilateral oophorosalpingectomy, postoperative medical treatment, e with a positive family history, while a decrease in the incidence of asymptomatic phenomena and those undergoing ovarian cystectomy compared to those with primary endometriosis. The naturally conceived pregnancy rate was higher in primary endometriosis compared to recurrent endometriosis. Compared to recurrent endometriosis with a negative family history, recurrent endometriosis with a positive family history had a higher incidence of severe dysmenorrhea, chronic pelvic pain, a higher spontaneous abortion rate, and a lower natural pregnancy rate. Primary endometriosis with a family history presented a higher incidence of severe dysmenorrhea than those without a family history. In conclusion, endometriosis patients with a positive family history presented a higher pain severity and lower conception probability compared to the sporadic cases. Recurrent endometriosis showed further-exacerbated clinical manifestations, more pronounced familial tendency, and lower pregnancy rates than primary endometriosis. Full article
(This article belongs to the Special Issue Cracking the Enigma of Endometriosis)
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18 pages, 3853 KiB  
Article
Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features
by Elena P. Khashchenko, Elena V. Uvarova, Timur Kh. Fatkhudinov, Vladimir D. Chuprynin, Aleksandra V. Asaturova, Elena A. Kulabukhova, Mikhail Yu. Vysokikh, Elvina Z. Allakhverdieva, Maria N. Alekseeva, Leila V. Adamyan and Gennady T. Sukhikh
J. Clin. Med. 2023, 12(4), 1678; https://doi.org/10.3390/jcm12041678 - 20 Feb 2023
Cited by 4 | Viewed by 3021
Abstract
Background: The early diagnosis of endometriosis in adolescents is not developed. Objective: We aim to conduct clinical, imaging, laparoscopic and histological analyses of peritoneal endometriosis (PE) in adolescents in order to improve early diagnosis. Methods: In total, 134 girls (from menarche to 17 [...] Read more.
Background: The early diagnosis of endometriosis in adolescents is not developed. Objective: We aim to conduct clinical, imaging, laparoscopic and histological analyses of peritoneal endometriosis (PE) in adolescents in order to improve early diagnosis. Methods: In total, 134 girls (from menarche to 17 years old) were included in a case–control study: 90 with laparoscopically (LS) confirmed PE, 44 healthy controls underwent full examination and LS was analyzed in the PE group. Results: Patients with PE were characterized with heredity for endometriosis, persistent dysmenorrhea, decreased daily activity, gastrointestinal symptoms, higher LH, estradiol, prolactin and Ca-125 (<0.05 for each). Ultrasound detected PE in 3.3% and MRI in 78.9%. The most essential MRI signs are as follows: hypointense foci, the heterogeneity of the pelvic tissue (paraovarian, parametrial and rectouterine pouch) and sacro-uterine ligaments lesions (<0.05 for each). Adolescents with PE mostly exhibit initial rASRM stages. Red implants correlated with the rASRM score, and sheer implants correlated with pain (VAS score) (<0.05). In 32.2%, foci consisted of fibrous, adipose and muscle tissue; black lesions were more likely to be histologically verified (0.001). Conclusion: Adolescents exhibit mostly initial PE stages, which are associated with greater pain. Persistent dysmenorrhea and detected MRI parameters predict the laparoscopic confirmation of initial PE in adolescents in 84.3% (OR 15.4; <0.01), justifying the early surgical diagnostics and shortening the time delay and suffering of the young patients. Full article
(This article belongs to the Special Issue Cracking the Enigma of Endometriosis)
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