Cardiomyopathy: Clinical Diagnosis and Treatment

Dear Colleagues, 

Takotsubo syndrome, proposed in 1990, is a myocardial disorder characterized by asystole of the apex of the heart that develops in response to severe physical or mental stress. It is believed that severe physical or mental stress leads to a rapid increase in catecholamines in the body, resulting in coronary artery spasm and microvascular dysfunction, which in turn affects cardiomyocytes. Initially, it was thought to have a similar pathogenesis to acute coronary syndromes in terms of symptoms, electrocardiographic changes, and left ventricular wall motion abnormalities, but with fewer complications and a better prognosis than acute coronary syndromes because there is no coronary artery occlusion, and the wall motion abnormalities are reversible. However, as the concept of the disease has been widely recognized around the world and many research results have been reported, it has become clear that it presents with various cardiac complications. In recent years, it has also become clear that the prognosis is not always favorable. Thus, since the concept of Takotsubo syndrome was first introduced, a great deal of knowledge has been accumulated, and its clinical landscape is gradually becoming clearer, but the pathogenesis remains unclear. Moreover, the pathogenesis of the disease remains unclear, and its elucidation is awaited in order to establish treatment guidelines for this disease. In this Special Issue, we would like to present the latest findings on Takotsubo cardiomyopathy from various viewpoints and share this information with readers.

Dr. Keiichi Hirono
Guest Editor

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