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Medical Cosmetic Skin Diseases: Starting from Acne and Facial Dermatitis

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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 9068

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Special Issue Editors

Dr. Bingrong Zhou

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Guest Editor

The Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Interests: keloid; scar; acne; sensitive skin; laser

Dr. Chao Yuan

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Guest Editor

Department of Skin & Cosmetic Research, The Shanghai Skin Disease Hospital of Tongji Medical University, Shanghai 200433, China
Interests: cosmetic skin diseases; rosacea; acne; skin microbiome

Dr. Yang Xu

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Guest Editor

The Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Interests: rosacea; acne; laser

Special Issue Information

Dear Colleagues,

Due to recent awareness of the impacts of facial skin diseases on life quality and mental stress, it is necessary to improve the understanding of the mechanism and therapy for these diseases including acne, rosacea, seborrheic dermatitis and so on. The mechanism of different facial dermatitis has not been completely clarified. In addition, the treatment of recurrent facial dermatitis and the problems left behind, such as facial erythema, pigmentation and scarring, also poses a challenge to clinicians.

The objective of this Special Issue is to attract and encourage the submission of novel mechanisms, clinical manifestations, key points for diagnosis, techniques and therapies for facial inflammatory diseases, to enhance the advances in these skin diseases.

We welcome researchers from cosmetics, academia and related-industry to provide their state-of-the-art technologies and ideas covering all aspects of better management of facial inflammatory diseases.

Dr. Bingrong Zhou
Dr. Chao Yuan
Dr. Yang Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

acne
rosacea
seborrheic dermatitis
sensitive skin
atopic dermatitis
pigmentation
scar
keloid
imaging technology
pathogenesis
treatment
laser
microbiomics
cosmetic

Published Papers (5 papers)

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Research

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18 pages, 2515 KiB

Open AccessArticle

Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis

by Dan-Qi Wang, Xi Li, Ru-Yi Zhang, Chao Yuan, Bo Yan, Philippe Humbert and Zhe-Xue Quan

J. Clin. Med. 2023, 12(18), 6078; https://doi.org/10.3390/jcm12186078 - 20 Sep 2023

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Abstract

The skin microbiota barrier participates in skin barrier function in addition to the physical, chemical, and immunological protective barriers, and is affected by environmental aggressors and skincare regimens. To better understand the exact effects of real-life environmental conditions on the skin and determine the protective methods, this study investigates the effects of three topical cosmetic moisturizers (water gel moisturizers with/without yeast extract (Moisturizers K and C) and a thick-emulsion cream moisturizer (Moisturizer L)) on clinical and skin microbiome endpoints in the presence of environmental aggressors during an 8-week, randomized controlled, triple-blind clinical trial with 110 participants, and molecular- as well as biomarker-level endpoints on ex vivo skin explants after exposure to simulate urban environmental conditions. The results show that all moisturizers are well-tolerated and improve skin barrier function and surface moisture content from the baseline, and the improvement is maintained at the last analysis point (3 days after trial completion). Compared with the untreated control areas (samples taken from the upper chest), treatment with Moisturizer K prevented a reduction in bacterial and fungal richness, and increased the change ratio of the relative abundance of commensal bacteria, such as Staphylococcus epidermidis and Ralstonia, at the treated sites (samples taken from the forehead). Moreover, Moisturizer K-treated ex vivo skin explants had higher levels of caspase 14 (a marker of skin barrier function), collagen I, and elastin (structure components), and lower levels of aryl hydrocarbon receptor (AHR; activated by air pollutants) and interleukin-6 (IL-6) than those in explants treated with other moisturizers and in the untreated areas of the skin. These results suggest that a skin postbiotic moisturizer with yeast extract supports the regulation of the skin’s microbiome balance and may provide a holistic barrier (involving skin microbiome, physical, chemical, and immune barriers) to protect the skin against environmental aggressors. Full article

(This article belongs to the Special Issue Medical Cosmetic Skin Diseases: Starting from Acne and Facial Dermatitis)

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9 pages, 256 KiB

Open AccessFeature PaperArticle

Prevalence, Intensity and Psychosocial Burden of Acne Itch: Two Different Cohorts Study

by Marta Szepietowska, Beata Bień, Piotr K. Krajewski, Aleksandra A. Stefaniak and Łukasz Matusiak

J. Clin. Med. 2023, 12(12), 3997; https://doi.org/10.3390/jcm12123997 - 12 Jun 2023

Cited by 2 | Viewed by 897

Abstract

Background: Chronic itch is a common symptom of inflammatory skin diseases. This study was undertaken to evaluate the presence and intensity of itching in two different cohorts of acne subjects. Additionally, the influence of itching on the psychosocial status of acne individuals was assessed. Methods: Consecutive acne patients seeking dermatological advice and university students diagnosed with acne during dermatological screening were considered. The clinical and psychological aspects of acne were assessed using a variety of instruments. Results: About 40% of acne subjects in both cohorts reported itching. The mean WI-NRS during the last 3 days in acne patients was 3.83 ± 2.31 points (mild itch) and was significantly more severe (p < 0.001) than in university students diagnosed with acne (2.09 ± 1.29 points). Itch intensity did not depend on the clinical severity of acne. In consecutive acne patients, itch intensity correlated with quality-of-life impairments (assessed using DLQI and CADI) and HADS scores. There was no correlation between itch intensity and stigmatization levels. Conclusions: Itching seems to be a common phenomenon in acne sufferers. Acne itch significantly influences patients’ well-being and should be considered in a holistic approach to acne patients. Full article

(This article belongs to the Special Issue Medical Cosmetic Skin Diseases: Starting from Acne and Facial Dermatitis)

9 pages, 774 KiB

Open AccessArticle

Increased Risk of Glaucoma in Patients with Rosacea: A Nationwide Population-Based Cohort Study

by Kyunghee Chae, Suyeon Kim, Sukil Kim and Yu Ri Woo

J. Clin. Med. 2023, 12(11), 3759; https://doi.org/10.3390/jcm12113759 - 30 May 2023

Viewed by 1086

Abstract

Rosacea is a chronic inflammatory skin disorder associated with various ocular manifestations. However, little is known about the association between rosacea and glaucoma. This study aimed to determine the risk of glaucoma in patients with rosacea. This nationwide population-based retrospective cohort study enrolled 1056 individuals with rosacea and 10,440 age- and sex-matched controls without rosacea from the Korean National Health Insurance System (NHIS) database from 2002 to 2015. The incidence rate of glaucoma was 1215.4 per 100,000 person-years (PYs) in patients with rosacea and 741.3 per 100,000 PYs in patients without rosacea. A significantly higher cumulative incidence probability of glaucoma was observed in patients with rosacea than in non-rosacea controls (p = 0.0004). Rosacea was associated with an increased risk of developing glaucoma (adjusted hazard ratio [aHR], 1.659; 95% confidence interval [CI], 1.245–2.211) compared to those without rosacea. In subgroup analysis, increased risk of glaucoma was observed in patients with rosacea younger than 50 years (aHR, 1.943; 95% CI, 1.305–2.893), females (aHR, 1.871; 95% CI, 1.324–2.644), and patients with hypertension (aHR, 1.561; 95% CI, 1.037–2.351) compared to those without rosacea. Rosacea is associated with an increased risk of developing glaucoma. Proper screening for glaucoma should be conducted in rosacea patients younger than 50 years, females, and patients with hypertension to better control the disease and prevent vision loss from glaucoma. Full article

(This article belongs to the Special Issue Medical Cosmetic Skin Diseases: Starting from Acne and Facial Dermatitis)

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12 pages, 551 KiB

Open AccessArticle

The Effectiveness of Pyruvic Acid Peeling in Improving the Quality of Life of Patients with Acne Vulgaris

by Beata Jankowska and Małgorzata Elżbieta Zujko

J. Clin. Med. 2023, 12(10), 3592; https://doi.org/10.3390/jcm12103592 - 22 May 2023

Cited by 2 | Viewed by 1849

Abstract

Improving the quality of life (QoL) of patients with various chronic diseases has become a challenge and priority of contemporary medicine. The aim of this study was to assess the impact of pyruvic acid peeling on the QoL of patients with acne vulgaris. The study group consisted of 200 young patients (mean age 23.04 ± 4.71) with acne vulgaris of mainly mild or moderate severity. Basic data about the patient were collected using a self-reported questionnaire. The assessment of QoL was carried out using standardized questionnaires: CADI (Cardiff Acne Disability Index), DLQI (Dermatology Life Quality Index), SWLS (Satisfaction With Life Scale), and BDI (Beck Depression Inventory). The cosmetic intervention consisted of chemical peeling with 35% pyruvic acid for acne lesions on the body and included four series repeated at 7-day intervals. This study demonstrated that acne vulgaris impairs the quality of life of young people. There were no significant differences between the severity of acne and the lifestyles of the subjects. The applied cosmetic procedure significantly decreased the severity of the acne and improved the quality of life of the patients. Full article

(This article belongs to the Special Issue Medical Cosmetic Skin Diseases: Starting from Acne and Facial Dermatitis)

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Review

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19 pages, 1483 KiB

Open AccessReview

The Emerging Role of Visible Light in Melanocyte Biology and Skin Pigmentary Disorders: Friend or Foe?

by Xuanxuan He, Shanglin Jin, Xiaoxi Dai, Li Chen, Leihong Xiang and Chengfeng Zhang

J. Clin. Med. 2023, 12(23), 7488; https://doi.org/10.3390/jcm12237488 - 04 Dec 2023

Cited by 2 | Viewed by 2909

Abstract

Electromagnetic radiation, notably visible light (VL), has complicated effects on human skin, particularly pigmentation, which have been largely overlooked. In this review, we discuss the photobiological mechanisms, pathological effects, clinical applications and therapeutic strategies of VL at varying wavelengths on melanocyte biology and skin pigmentary disorders. Different VL wavelengths may impose positive or negative effects, depending on their interactions with specific chromophores, photoaging, ROS production, circadian rhythm and other photon-mediated reactions. Further in vivo and in vitro studies are required to establish the pathologic mechanisms and application principles of VL in pigmentary disorders, as well as optimal photoprotection with coverage against VL wavelengths. Full article

(This article belongs to the Special Issue Medical Cosmetic Skin Diseases: Starting from Acne and Facial Dermatitis)

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