Prevalence, Intensity and Psychosocial Burden of Acne Itch: Two Different Cohorts Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Assessment of Acne Severity
2.3. Assessment of Itching
2.4. Assessment of Psychosocial Burden
2.5. Statistical Analysis
3. Results
3.1. Cohort I Results
3.2. Cohort II Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Wolkenstein, P.; Machovcova, A.; Szepietowski, J.C.; Tennstedt, D.; Veraldi, S.; Delarue, A. Acne prevalence and associations with lifestyle: A cross-sectional online survey of adolescents/young adults in 7 European countries. J. Eur. Acad. Dermatol. Venereol. 2018, 32, 298–306. [Google Scholar] [CrossRef] [PubMed]
- Dreno, B.; Poli, F. Epidemiology of acne. Dermatology 2003, 206, 7–10. [Google Scholar] [CrossRef] [PubMed]
- Dreno, B. Recent data on epidemiology of acne. Ann. Dermatol. Venereol. 2010, 137 (Suppl. 2), S49–S51. [Google Scholar] [CrossRef]
- Rzany, B.; Kahl, C. Epidemiology of acne vulgaris. J. Dtsch. Dermatol. Ges. 2006, 4, 8–9. [Google Scholar] [CrossRef]
- Altunay, I.K.; Ozkur, E.; Dalgard, F.J.; Gieler, U.; Tomas Aragones, L.; Lien, L.; Poot, F.; Jemec, G.B.; Misery, L.; Szabo, C.; et al. Psychosocial Aspects of Adult Acne: Data from 13 European Countries. Acta Derm. Venereol. 2020, 100, adv00051. [Google Scholar] [CrossRef] [Green Version]
- Dalgard, F.J.; Gieler, U.; Tomas-Aragones, L.; Lien, L.; Poot, F.; Jemec, G.B.E.; Misery, L.; Szabo, C.; Linder, D.; Sampogna, F.; et al. The psychological burden of skin diseases: A cross-sectional multicenter study among dermatological out-patients in 13 European countries. J. Investig. Dermatol. 2015, 135, 984–991. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Szepietowska, M.; Dabrowska, A.; Nowak, B.; Skinderowicz, K.; Wilczynski, B.; Krajewski, P.K.; Jankowska-Konsur, A. Alexithymia in Adolescents with Acne: Association with Quality of Life Impairment and Stigmatization. J. Clin. Med. 2022, 11, 732. [Google Scholar] [CrossRef]
- Lim, T.H.; Badaruddin, N.S.F.; Foo, S.Y.; Bujang, M.A.; Muniandy, P. Prevalence and psychosocial impact of acne vulgaris among high school and university students in Sarawak, Malaysia. Med. J. Malays. 2022, 77, 446–453. [Google Scholar]
- Alqahtani, A.; Alsaab, W.I.; Altulahi, B. Psychological Impact of Acne Vulgaris on the Young Saudi Population. Cureus 2021, 13, e20509. [Google Scholar] [CrossRef]
- Szepietowska, M.; Dabrowska, A.; Nowak, B.; Skinderowicz, K.; Wilczynski, B.; Krajewski, P.K.; Jankowska-Konsur, A. Prevalence and quality of life of facial acne: A cross-sectional study in high school students in Poland. Postep. Dermatol. Alergol. 2022, 39, 1035–1039. [Google Scholar] [CrossRef]
- Szepietowska, M.; Dabrowska, A.; Nowak, B.; Skinderowicz, K.; Wilczynski, B.; Krajewski, P.K.; Jankowska-Konsur, A. Facial acne causes stigmatization among adolescents: A cross-sectional study. J. Cosmet. Dermatol. 2022, 21, 6815–6821. [Google Scholar] [CrossRef] [PubMed]
- Gollnick, H.P.; Bettoli, V.; Lambert, J.; Araviiskaia, E.; Binic, I.; Dessinioti, C.; Galadari, I.; Ganceviciene, R.; Ilter, N.; Kaegi, M.; et al. A consensus-based practical and daily guide for the treatment of acne patients. J. Eur. Acad. Dermatol. Venereol. 2016, 30, 1480–1490. [Google Scholar] [CrossRef] [PubMed]
- Ballanger, F.; Claudel, J.P.; Leccia, M.T.; Auffret, N.; Stromstedt Camerati, A.; Dufaux, P.O.; Marquie, A.; Dreno, B. Truncal Acne in Adolescents and Young Adults: Self-reported Perception. Acta Derm. Venereol. 2023, 103, adv5123. [Google Scholar] [CrossRef] [PubMed]
- Reich, A.; Trybucka, K.; Tracinska, A.; Samotij, D.; Jasiuk, B.; Srama, M.; Szepietowski, J.C. Acne itch: Do acne patients suffer from itching? Acta Derm. Venereol. 2008, 88, 38–42. [Google Scholar] [CrossRef] [Green Version]
- Lim, Y.L.; Chan, Y.H.; Yosipovitch, G.; Greaves, M.W. Pruritus is a common and significant symptom of acne. J. Eur. Acad. Dermatol. Venereol. 2008, 22, 1332–1336. [Google Scholar] [CrossRef]
- Wang, X.; Lai, Q.; Zheng, B.; Ye, L.; Wen, S.; Yan, Y.; Yang, B.; Man, M.Q. Both Prevalence and Severity of Pruritus are Associated with Age in Chinese Patients with Skin Diseases. Clin. Cosmet. Investig Dermatol. 2021, 14, 217–223. [Google Scholar] [CrossRef]
- Dalgard, F.; Halvorsen, J.A.; Kwatra, S.G.; Yosipovitch, G. Acne severity and itch are associated: Results from a Norwegian survey of 3775 adolescents. Br. J. Dermatol. 2013, 169, 215–216. [Google Scholar] [CrossRef]
- Huet, F.; Taieb, C.; Corgibet, F.; Brenaut, E.; Richard, M.A.; Misery, L. Pruritus, Pain, and Depression Associated with the Most Common Skin Diseases: Data from the French Study “Objectifs Peau”. Dermatology 2022, 238, 448–453. [Google Scholar] [CrossRef]
- Alsulaimani, H.; Kokandi, A.; Khawandanh, S.; Hamad, R. Severity of Acne Vulgaris: Comparison of Two Assessment Methods. Clin. Cosmet. Investig. Dermatol. 2020, 13, 711–716. [Google Scholar] [CrossRef]
- Reich, A.; Chatzigeorkidis, E.; Zeidler, C.; Osada, N.; Furue, M.; Takamori, K.; Ebata, T.; Augustin, M.; Szepietowski, J.C.; Stander, S. Tailoring the Cut-off Values of the Visual Analogue Scale and Numeric Rating Scale in Itch Assessment. Acta Derm. Venereol. 2017, 97, 759–760. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Finlay, A.Y.; Khan, G.K. Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. Clin. Exp. Dermatol. 1994, 19, 210–216. [Google Scholar] [CrossRef] [PubMed]
- Motley, R.J.; Finlay, A.Y. How much disability is caused by acne? Clin. Exp. Dermatol. 1989, 14, 194–198. [Google Scholar] [CrossRef] [PubMed]
- Abdelrazik, Y.T.; Ali, F.M.; Salek, M.S.; Finlay, A.Y. Clinical experience and psychometric properties of the Cardiff Acne Disability Index (CADI). Br. J. Dermatol. 2021, 185, 711–724. [Google Scholar] [CrossRef]
- Lu, Y.; Duller, P.; van der Valk, P.G.M.; Evers, A.W.M. Helplessness as Predictor of Perceived Stigmatization in Patients with Psoriasis and Atopic Dermatitis. Dermatol. Psychosom./Dermatol. Und Psychosom. 2003, 4, 146–150. [Google Scholar] [CrossRef]
- Dimitrov, D.; Szepietowski, J.C. Instruments to assess stigmatization in dermatology. Adv. Hyg. Exp. Med. 2017, 71, 901–905. [Google Scholar] [CrossRef] [PubMed]
- Zigmond, A.S.; Snaith, R.P. The hospital anxiety and depression scale. Acta Psychiatr. Scand. 1983, 67, 361–370. [Google Scholar] [CrossRef] [Green Version]
- Majkowicz, M.; Walden-Galuszko, K. Ocena Jakości Opieki Paliatywnej w Teorii i Praktyce; Akademia Medyczna: Gdańsk, Poland, 2000. [Google Scholar]
- Hrehorow, E.; Szepietowski, J.; Reich, A.; Evers, A.W.M.; Ginsburg, I.H. Narzędzia do oceny stygmatyzacji u chorych na łuszczycę: Polskie wersje językowe. Derm. Klin. 2006, 8, 253–258. [Google Scholar]
- Szepietowski, J.; Salomon, J.; Finlay, A.Y.; Klepacki, A.; Chodynicka, B.; Marionneau, N.; Taieb, C.; Myon, E. Dermatology Life Quality Index (DLQI): Polish version. Derm. Klin. 2004, 6, 63–70. [Google Scholar]
- Weisshaar, E.; Szepietowski, J.C.; Darsow, U.; Misery, L.; Wallengren, J.; Mettang, T.; Gieler, U.; Lotti, T.; Lambert, J.; Maisel, P.; et al. European guideline on chronic pruritus. Acta Derm. Venereol. 2012, 92, 563–581. [Google Scholar] [CrossRef] [Green Version]
- Weisshaar, E.; Szepietowski, J.C.; Dalgard, F.J.; Garcovich, S.; Gieler, U.; Gimenez-Arnau, A.M.; Lambert, J.; Leslie, T.; Mettang, T.; Misery, L.; et al. European S2k Guideline on Chronic Pruritus. Acta Derm. Venereol. 2019, 99, 469–506. [Google Scholar] [CrossRef] [Green Version]
- Stander, S.; Weisshaar, E.; Mettang, T.; Szepietowski, J.C.; Carstens, E.; Ikoma, A.; Bergasa, N.V.; Gieler, U.; Misery, L.; Wallengren, J.; et al. Clinical classification of itch: A position paper of the International Forum for the Study of Itch. Acta Derm. Venereol. 2007, 87, 291–294. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Matterne, U.; Apfelbacher, C.J.; Vogelgsang, L.; Loerbroks, A.; Weisshaar, E. Incidence and determinants of chronic pruritus: A population-based cohort study. Acta Derm. Venereol. 2013, 93, 532–537. [Google Scholar] [CrossRef] [PubMed]
- Reszke, R.; Szepietowski, J.C. Itch and Psyche: Bilateral Associations. Acta Derm. Venereol. 2020, 100, adv00026. [Google Scholar] [CrossRef] [Green Version]
- Dalgard, F.J.; Svensson, A.; Halvorsen, J.A.; Gieler, U.; Schut, C.; Tomas-Aragones, L.; Lien, L.; Poot, F.; Jemec, G.B.E.; Misery, L.; et al. Itch and Mental Health in Dermatological Patients across Europe: A Cross-Sectional Study in 13 Countries. J. Investig. Dermatol. 2020, 140, 568–573. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Lebwohl, M.G.; Bachelez, H.; Barker, J.; Girolomoni, G.; Kavanaugh, A.; Langley, R.G.; Paul, C.F.; Puig, L.; Reich, K.; van de Kerkhof, P.C. Patient perspectives in the management of psoriasis: Results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey. J. Am. Acad. Dermatol. 2014, 70, 871–881.e30. [Google Scholar] [CrossRef]
- Reszke, R.; Bialynicki-Birula, R.; Szepietowski, J.C. Itch in Psoriasis: A New Look at Well-known Subject. Acta Derm. Venereol. 2019, 99, 429–434. [Google Scholar] [CrossRef] [Green Version]
- Reich, A.; Szepietowski, J.C. Clinical Aspects of Itch: Psoriasis. In Itch: Mechanisms and Treatment; Carstens, E., Akiyama, T., Eds.; Frontiers in Neuroscience; CRC Press: Boca Raton, FL, USA, 2014. [Google Scholar]
- Szepietowski, J.C.; Reich, A.; Wisnicka, B. Itching in patients suffering from psoriasis. Acta Dermatol. Croat. 2002, 10, 221–226. [Google Scholar]
- Chrostowska-Plak, D.; Salomon, J.; Reich, A.; Szepietowski, J.C. Clinical aspects of itch in adult atopic dermatitis patients. Acta Derm. Venereol. 2009, 89, 379–383. [Google Scholar] [CrossRef] [Green Version]
- Welz-Kubiak, K.; Reich, A.; Szepietowski, J.C. Clinical Aspects of Itch in Lichen Planus. Acta Derm. Venereol. 2017, 97, 505–508. [Google Scholar] [CrossRef] [Green Version]
- Reich, A.; Welz-Kubiak, K.; Szepietowski, J.C. Pruritus differences between psoriasis and lichen planus. Acta Derm. Venereol. 2011, 91, 605–606. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Reich, A.; Stander, S.; Szepietowski, J.C. Drug-induced pruritus: A review. Acta Derm. Venereol. 2009, 89, 236–244. [Google Scholar] [CrossRef] [Green Version]
- Reich, A.; Medrek, K.; Szepietowski, J.C. Interplay of Itch and Psyche in Psoriasis: An Update. Acta Derm. Venereol. 2016, 96, 55–57. [Google Scholar] [CrossRef]
- Reich, A.; Hrehorow, E.; Szepietowski, J.C. Pruritus is an important factor negatively influencing the well-being of psoriatic patients. Acta Derm. Venereol. 2010, 90, 257–263. [Google Scholar] [CrossRef] [Green Version]
- Jaworecka, K.; Rzepko, M.; Marek-Jozefowicz, L.; Tamer, F.; Stefaniak, A.A.; Szczegielniak, M.; Chojnacka-Purpurowicz, J.; Gulekon, A.; Szepietowski, J.C.; Narbutt, J.; et al. The Impact of Pruritus on the Quality of Life and Sleep Disturbances in Patients Suffering from Different Clinical Variants of Psoriasis. J. Clin. Med. 2022, 11, 5553. [Google Scholar] [CrossRef]
- Chrostowska-Plak, D.; Reich, A.; Szepietowski, J.C. Relationship between itch and psychological status of patients with atopic dermatitis. J. Eur. Acad. Dermatol. Venereol. 2013, 27, e239–e242. [Google Scholar] [CrossRef]
- Kaaz, K.; Szepietowski, J.C.; Matusiak, L. Influence of Itch and Pain on Sleep Quality in Patients with Hidradenitis Suppurativa. Acta Derm. Venereol. 2018, 98, 757–761. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Verma, S.; Vasani, R.; Reszke, R.; Matusiak, L.; Szepietowski, J.C. Prevalence and clinical characteristics of itch in epidemic-like scenario of dermatophytoses in India: A cross-sectional study. J. Eur. Acad. Dermatol. Venereol. 2020, 34, 180–183. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Chlebicka, I.; Stefaniak, A.A.; Matusiak, L.; Szepietowski, J.C. Burden of Itch in Patients with Basal Cell Carcinoma. Acta Derm. Venereol. 2021, 101, adv00507. [Google Scholar] [CrossRef] [PubMed]
- Lelonek, E.; Matusiak, L.; Wrobel, T.; Kwiatkowski, J.; Szepietowski, J.C. Burden of Aquagenic Pruritus in Polycythaemia Vera. Acta Derm. Venereol. 2018, 98, 185–190. [Google Scholar] [CrossRef] [Green Version]
- Susel, J.; Batycka-Baran, A.; Reich, A.; Szepietowski, J.C. Uraemic pruritus markedly affects the quality of life and depressive symptoms in haemodialysis patients with end-stage renal disease. Acta Derm. Venereol. 2014, 94, 276–281. [Google Scholar] [CrossRef] [Green Version]
- Szepietowski, J.C.; Balaskas, E.; Taube, K.M.; Taberly, A.; Dupuy, P.; Uraemic Xerosis Working, G. Quality of life in patients with uraemic xerosis and pruritus. Acta Derm. Venereol. 2011, 91, 313–317. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Stefaniak, A.A.; Krajewski, P.K.; Bednarska-Chabowska, D.; Bolanowski, M.; Mazur, G.; Szepietowski, J.C. Itch in Adult Population with Type 2 Diabetes Mellitus: Clinical Profile, Pathogenesis and Disease-Related Burden in a Cross-Sectional Study. Biology 2021, 10, 1332. [Google Scholar] [CrossRef] [PubMed]
- Stefaniak, A.A.; Zubkiewicz-Kucharska, A.; Matusiak, L.; Noczynska, A.; Szepietowski, J.C. Itch in Children with Type 1 Diabetes: A Cross-Sectional Study. Dermatol. Ther. 2020, 10, 745–756. [Google Scholar] [CrossRef] [PubMed]
- Krajewski, P.K.; Tyczynska, K.; Bardowska, K.; Olczyk, P.; Krajewska, M.; Szepietowski, J.C. Psychosocial Burden of Itch among Renal Transplant Recipients. Toxins 2022, 14, 320. [Google Scholar] [CrossRef] [PubMed]
- Jiao, R.; Zhai, X.; Zhang, X.; Xiong, Z.; Liu, Z. Efficacy of acupuncture in improving symptoms and quality of life of patients with acne vulgaris: A randomized sham acupuncture-controlled trial. Acupunct. Med. 2022, 40, 453–462. [Google Scholar] [CrossRef]
Cohort I | Cohort II | p | |
---|---|---|---|
Subjects [N (%)] | |||
Whole group | 104 (100) | 202 (100) | |
Females | 69 (66.3) | 127 (62.9) | NS |
Males | 35 (33.7) | 75 (37.1) | |
Age [Mean, range] | |||
Whole group | 20.38 ± 5.78; 12–39 | 22.7 ± 1.6; 20–31 | p < 0.001 |
Females | 21.07 ± 6.25; 12–39 | 22.83 ± 1.85; 21–31 | p < 0.001 |
Males | 19.0 ± 4.5; 13–32 | 22.49 ± 1.17; 20–27 | p < 0.001 |
Acne severity (IGA) [points] | |||
Whole group | 3.22 ± 0.7 | 1.92 ± 0.74 | p < 0.001 |
Females | 3.10 ± 0.71 * | 1.90 ± 0.78 | p < 0.001 |
Males | 3.46 ± 0.61 * | 1.95 ± 0.68 | p < 0.001 |
Itch | Whole Group (n = 104) | Females (n = 69) | Males (n = 35) | p |
---|---|---|---|---|
Presence of itching [N (%)] | 41 (39.4) | 52 (40.9) | 10 (28.6) | NS |
Mean itch during the entire acne period [points] | 3.83 ± 2.31 | 3.55 ± 2.20 | 5.10 ± 2.75 | NS |
Mean itch during the last 3 days [points] | 3.12 ± 2.28 | 2.48 ± 1.73 | 4.77 ± 2.25 | p = 0.004 |
Itch | IGA | DLQI | CADI | 6-ISS | HADS Total | HADS A | HADS D |
---|---|---|---|---|---|---|---|
During the entire disease | |||||||
Whole group (n = 41) | NS | r = 0.394 p = 0.011 | NS | NS | r = 0.482 p = 0.002 | r = 0.325 p = 0.041 | r = 0.427 p = 0.006 |
Females (n = 31) | NS | r = 0.534 p = 0.003 | r = 0.415 p = 0.02 | NS | NS | NS | r = 0.372 p = 0.04 |
Males (n = 10) | NS | NS | NS | NS | NS | NS | NS |
During the last 3 days | |||||||
Whole group (n = 41) | NS | r = 0.447 p = 0.011 | NS | NS | r = 0.390 p = 0.002 | NS | r = 0.352 p = 0.026 |
Females (n = 31) | NS | r = 0.543 p = 0.002 | r = 0.373 p = 0.039 | NS | NS | NS | NS |
Males (n = 10) | NS | r = 0.543 p = 0.002 | NS | NS | NS | NS | NS |
Itch | Whole Group (n = 202) | Females (n = 127) | Males (n = 75) | p |
---|---|---|---|---|
Presence of itching [N (%)] | 81 (40.1) | 52 (40.9) | 29 (38.7) | NS |
Mean itch during the last 3 days [points] | 2.09 ±1.29 | 2.04 ±1.33 | 2.17 ± 1.23 | NS |
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Szepietowska, M.; Bień, B.; Krajewski, P.K.; Stefaniak, A.A.; Matusiak, Ł. Prevalence, Intensity and Psychosocial Burden of Acne Itch: Two Different Cohorts Study. J. Clin. Med. 2023, 12, 3997. https://doi.org/10.3390/jcm12123997
Szepietowska M, Bień B, Krajewski PK, Stefaniak AA, Matusiak Ł. Prevalence, Intensity and Psychosocial Burden of Acne Itch: Two Different Cohorts Study. Journal of Clinical Medicine. 2023; 12(12):3997. https://doi.org/10.3390/jcm12123997
Chicago/Turabian StyleSzepietowska, Marta, Beata Bień, Piotr K. Krajewski, Aleksandra A. Stefaniak, and Łukasz Matusiak. 2023. "Prevalence, Intensity and Psychosocial Burden of Acne Itch: Two Different Cohorts Study" Journal of Clinical Medicine 12, no. 12: 3997. https://doi.org/10.3390/jcm12123997