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Innovations and Future Directions in Valvular Heart Disease: Imaging, Technology, and Translational Research

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 December 2025 | Viewed by 681

Special Issue Editors


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Guest Editor
1. Clinic for General and Interventional Cardiology/Angiology, Heart and Diabetes Center, Bad Oeynhausen, Germany
2. Department of Cardiology, Inselspital Bern, Bern University Hospital, 3012 Bern, Switzerland
Interests: cardiology; echocardiography; valvular heart disease; interventional cardiology; minimally invasive AV-valve interventions
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, 32545 Bad Oeynhausen, Germany
Interests: valvular heart disease; interventional cardiology; mitral regurgitation; tricuspid regurgitation

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Guest Editor Assistant
Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, 32545 Bad Oeynhausen, Germany
Interests: valvular heart disease; interventional cardiology; mitral regurgitation; tricuspid regurgitation; aortic stenosis; PFO

Special Issue Information

Dear Colleagues,

Valvular heart disease (VHD) is undergoing a transformative era driven by rapid technological innovation and interdisciplinary research. This Special Issue will spotlight the next frontier in VHD by focusing on novel diagnostic imaging techniques, advanced computational modeling, and translational approaches that bridge bench-to-bedside progress. Cutting-edge tools such as artificial intelligence-assisted echocardiography, cardiac MRI with radiomics, and patient-specific 3D-printed valves are redefining how we understand, diagnose, and treat valvular disorders.

In parallel, developments in tissue engineering, bioresorbable scaffolds, and next-generation transcatheter devices are paving the way for more personalized and durable therapies. An emphasis will also be placed on early disease detection using omics technologies and machine learning models, as well as future perspectives in precision medicine for VHD.

We invite original research and comprehensive reviews that explore these exciting innovations and will help shape the future of valvular heart disease management.

Dr. Mohammad Kassar
Dr. Muhammed Gerçek
Guest Editors

Dr. Felix Rudolph
Guest Editor Assistant

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Keywords

  • prosthetic heart valve
  • heart valve pathophysiology
  • structural heart valve interventions
  • echocardiographic assessment
  • cardiovascular imaging
  • valvular heart disease
  • valvular regurgitation
  • valvular stenosis
  • minimally invasive surgery
  • concomitant valve disease

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Published Papers (2 papers)

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Research

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17 pages, 1243 KB  
Article
Characterization of Patients Unsuited for Transcatheter Mitral Valve Interventions
by Carolina Göttsche Esperança Clara, Hannah Eustergerling, Johanna Isabella Pepping, Vanessa Trenkpohl, Kai Peter Friedrichs, Maria Ivannikova, Tanja Katharina Rudolph, Johanna Bormann, Johannes Kirchner, Max Potratz, Volker Rudolph, Mohammad Kassar, Muhammed Gerçek and Felix Rudolph
J. Clin. Med. 2025, 14(20), 7275; https://doi.org/10.3390/jcm14207275 - 15 Oct 2025
Viewed by 342
Abstract
Background/Objectives: The objective of this study was to characterize echocardiographic characteristics comparing patients accepted or deemed unsuitable for transcatheter mitral valve interventions. Methods: We performed a retrospective analysis of 293 patients with severe mitral regurgitation evaluated for mitral transcatheter edge-to-edge repair [...] Read more.
Background/Objectives: The objective of this study was to characterize echocardiographic characteristics comparing patients accepted or deemed unsuitable for transcatheter mitral valve interventions. Methods: We performed a retrospective analysis of 293 patients with severe mitral regurgitation evaluated for mitral transcatheter edge-to-edge repair (M-TEER) or transcatheter mitral valve replacement (TMVR), if patients were primarily identified as unsuitable candidates for M-TEER, at our institution between 2018 and 2023. All patients underwent transthoracic and transesophageal echocardiography, and mitral valve quantification (MVQ) analysis was performed. Feasibility was determined by an interdisciplinary Heart Team based on quantitative data and semi-quantitative echocardiographic parameters, including mean pressure gradient, regurgitation volumes, and morphological aspects alongside clinical assessment. Patient characteristics were evaluated using clinical records and echocardiographic data. Results: We screened 195 patients for M-TEER, 168 of which were accepted for the procedure. M-TEER-rejected patients presented with higher regurgitation volumes and higher transmitral pressure gradients than those accepted to undergo M-TEER. We then screened 104 patients for TMVR, and 27 were approved for the procedure. Patients rejected for TMVR presented with lower tenting volume, area, and height and had smaller ventricular diameters. Further, mitral valve area appears to be an important parameter in determining MR treatment strategy. Conclusions: The majority of MR patients screened for transcatheter intervention were suitable for M-TEER. However, elevated MPG and more pronounced billowing were the main factors associated with M-TEER exclusion. Conversely, the only morphological parameter associated with TMVR refusal was small left ventricular size. Importantly, the multimorbidity of patients and level of critical illness did not prohibit TMVR. Full article
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Review

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15 pages, 4192 KB  
Review
Transcatheter Tricuspid Valve Annuloplasty with the Cardioband System: A Step-by-Step Guide
by Maria Laura Novembre, Lluis Asmarats, Chi Hion Pedro Li, Marcel Santaló-Corcoy, Xavier Millán and Dabit Arzamendi
J. Clin. Med. 2025, 14(21), 7772; https://doi.org/10.3390/jcm14217772 - 1 Nov 2025
Viewed by 130
Abstract
Direct transcatheter tricuspid valve annuloplasty represents a significant advancement in the treatment of severe symptomatic tricuspid regurgitation. Previous studies have shown the efficacy of transcatheter annuloplasty with significant reductions in tricuspid regurgitation and improvements in functional status. The aim of this review is [...] Read more.
Direct transcatheter tricuspid valve annuloplasty represents a significant advancement in the treatment of severe symptomatic tricuspid regurgitation. Previous studies have shown the efficacy of transcatheter annuloplasty with significant reductions in tricuspid regurgitation and improvements in functional status. The aim of this review is to provide a comprehensive step-by-step guide to the procedure, focusing on appropriate patient selection, main procedural steps and identification and management of possible complications to enhance our understanding of the procedure and maximize procedural success. Full article
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