Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
3.9
Journals
JCM
Special Issues
Potentially Malignant Disorders and Cancers of Head and Neck Region—Series...
share announcement

Potentially Malignant Disorders and Cancers of Head and Neck Region—Series 2

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 15 September 2024 | Viewed by 2860

Special Issue Editor

Dr. Luís Silva Monteiro

E-Mail Website
Guest Editor
Biopathology, Oral Medicine and Oral Pathology at University Institute of Health Sciences (IUCS), Director of the UNIPRO—Oral Pathology and Rehabilitation Research Unit at IUCS, Rua Central de Gandra, 1317, 4585-116 Gandra, PRD, Portugal
Interests: oral cancer; molecular biology; oral carcinogenesis; cell cycle regulation; epidemiology; laser applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It was a pleasure to collaborate as a Guest Editor in the Special Issue “Clinical Emerging Diagnostic and Screening Adjuncts in Potentially Malignant Disorders and Cancers of Head and Neck Region” for the Journal of Clinical Medicine (https://www.mdpi.com/journal/jcm/special_issues/Diagnostic_Screening_Adjuncts_Cancers_Head_Neck). Our goal now is to launch a second edition of the Special Issue, titled “Potentially Malignant Disorders and Cancers of Head and Neck Region—Series 2”.

Head and neck cancer is a major public health problem worldwide, as it is the sixth most common cancer worldwide and has low survival rates, even in recent decades.

Head and neck tumorigenesis involves an accumulation of multiple genetic and epigenetic alterations from several important pathways, providing opportunities for cancer development and progression. Many of these cancers can be preceded by potentially malignant disorders, manifesting clinically as a series of mucosal alterations which could increase the risk of individuals with these disorders being diagnosed with cancer in their lifetime. In view of this, many studies have focused on increasing the identification of head and neck cancer and the precision of detecting early alterations that can develop into cancer or already represent areas of malignancy.

In a clinical context, many tools and methods have been developed to increase the accuracy in order to identify the most suspicious areas for malignancy, to define correct margins of lesions or simply to help in the screening and follow-up of patients, including optical analysis systems, cytological methods, vital stainings, or the use of biomarkers in tissues or even saliva.

In view of this, we invite authors to submit research or review articles to be published in this Special Issue that describe the most recent evaluations regarding diagnostic and screening tools or methods with potential use in the diagnosis or prognosis of head and neck cancers, also including potential malignant disorders.

Dr. Luís Silva Monteiro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autofluorescence
  • vital staining
  • chemiluminescence light
  • laser-induced fluorescence
  • liquid biopsy
  • optical coherence tomography
  • contact endoscopy
  • narrow-band imaging (NBI) endoscopy
  • saliva
  • biomarkers
  • high-resolution sonography
  • precision medicine
  • LOH
  • SNPs
  • predictives
  • prognostic
  • diagnostic
  • head and neck cancers
  • oral potentially malignant disorders

Related Special Issue

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

11 pages, 3002 KiB  
Article
Expression of p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 Markers in Actinic Keratosis, In Situ Squamous Cell Carcinoma and Normal Sun-Exposed Skin of Elderly Patients
by Alise Balcere, Māris Sperga, Ingrīda Čēma, Gunārs Lauskis, Maksims Zolovs, Māra Rone Kupfere and Angelika Krūmiņa
J. Clin. Med. 2023, 12(23), 7291; https://doi.org/10.3390/jcm12237291 - 24 Nov 2023
Cited by 1 | Viewed by 1277
Abstract
Background: Age and cumulative exposure to ultraviolet (UV) light are primary contributors to skin cancer development. Regulatory proteins within the cell cycle are essential for the homeostasis of squamous epithelium. Methods: This study assessed the expression of immunohistochemical markers p53, p63, p16, Ki67, [...] Read more.
Background: Age and cumulative exposure to ultraviolet (UV) light are primary contributors to skin cancer development. Regulatory proteins within the cell cycle are essential for the homeostasis of squamous epithelium. Methods: This study assessed the expression of immunohistochemical markers p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 in keratinocyte intraepithelial neoplasia (actinic keratosis and squamous cell carcinoma in situ) compared to normal skin. The objective was to distinguish disease-specific changes from those attributable to ageing and sun exposure in elderly skin. Results. Analysis included 22 actinic keratoses (AK), 7 in situ squamous cell carcinomas (SCC), and 8 normal skin biopsies. The mean age was 78.1 years for the AK/SCC group and 73.8 years for controls, with no significant age difference noted between the groups. The AK/SCC group exhibited a higher occurrence of amorphous masses, higher intensity of p53, lower Bcl-2 expression in the epidermis, higher Bcl-2 expression in the dermis, and higher CD31 expression in the dermis, all of which were statistically significant (p < 0.05). Conclusions: The study identifies distinct differences in the presence of amorphous masses and the expression levels of p53, Bcl-2, and CD31 between sun-exposed skin and in situ cutaneous squamous cell carcinomas, including actinic keratoses. Full article
(This article belongs to the Special Issue Potentially Malignant Disorders and Cancers of Head and Neck Region—Series 2)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

13 pages, 609 KiB  
Review
Oral Potentially Malignant Disorders and Oral Cancer in Saudi Arabia: An Epidemiological Review of the Literature
by Khalid Aljohani, Ali Alqarni, Molly Harte, Rawia Alghamdi, Saja Alzahrani and Rui Albuquerque
J. Clin. Med. 2024, 13(5), 1376; https://doi.org/10.3390/jcm13051376 - 28 Feb 2024
Viewed by 775
Abstract
Background: Oral potentially malignant disorders (OPMDs) are a group of chronic oral mucosal diseases associated with an increased risk of malignant transformation. Multiple studies have investigated the prevalence of these conditions in multiple regions; however, there are limited data about the prevalence of [...] Read more.
Background: Oral potentially malignant disorders (OPMDs) are a group of chronic oral mucosal diseases associated with an increased risk of malignant transformation. Multiple studies have investigated the prevalence of these conditions in multiple regions; however, there are limited data about the prevalence of OPMDs in the Kingdom of Saudi Arabia (KSA). This paper aims to review the prevalence of OPMDs in the KSA, to ensure better understanding of the population risk and propose a more standardised approach to the diagnosis and management of this group across the KSA. In addition, this review will discuss the prevalence of oral cancer in the KSA, considering independent risk factors for oral cancer development. Methods: Electronic databases including PubMed, Medline, Medscape, ScienceDirect, StatPearls, BMC Oral Health and the Cochrane Library were searched with the keywords “Oral Potentially Malignant Disorders”; “Saudi Arabia”; and “Oral Cancer”. Identified articles were reviewed independently by 2 reviewers against defined inclusion and exclusion criteria. Results: 16 studies were included in this review. The prevalence of OPMDs in KSA varies significantly depending on age, gender, social habits, background disease and dental status. Conclusions: This review highlights the need for up-to-date data on the prevalence, distribution, and characteristics of OPMDs in KSA. The diverse prevalence rates and distinct characteristics of various OPMDs emphasise the necessity for targeted preventive measures. As the data on OPMDs in KSA remains limited, future research efforts should prioritise the establishment of comprehensive epidemiological studies to inform effective public health interventions in this region. Full article
(This article belongs to the Special Issue Potentially Malignant Disorders and Cancers of Head and Neck Region—Series 2)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

12 pages, 468 KiB  
Brief Report
Osteonecrosis of the Jaw Associated with Bisphosphonates Infusion for Treatment of Plasma Cell Myeloma—A Retrospective Observational Study of Northern Portuguese Population
by Sara Sousa Ferreira, José Barbas do Amaral, José Júlio Pacheco, Filomena Salazar and Luís Monteiro
J. Clin. Med. 2024, 13(9), 2679; https://doi.org/10.3390/jcm13092679 - 02 May 2024
Viewed by 173
Abstract
To verify medication-related osteonecrosis of the jaw (MRONJ) frequency among patients with plasma cell myeloma (PCM) that had been treated with bisphosphonates, to identify predisposing factors that could influence the development of osteonecrosis. Methods: This observational retrospective study was performed at the [...] Read more.
To verify medication-related osteonecrosis of the jaw (MRONJ) frequency among patients with plasma cell myeloma (PCM) that had been treated with bisphosphonates, to identify predisposing factors that could influence the development of osteonecrosis. Methods: This observational retrospective study was performed at the Department of Hematology of Hospital Center of Porto (CHUP), Portugal. Results: The study population (n = 112) had a 15.2% (n = 17) prevalence of osteonecrosis. Clinically, bone exposure was the most frequently observed sign, present in 100% (n = 17) of the patients, followed by inflammation in 82.4% (n = 14), orofacial pain in 70.6% (n = 12), suppuration in 47.1% (n = 8), and intra or extra-oral fistula in 17.6% (n = 3) of the cases. The most frequent triggering local factor was dental extraction (82.4%). There was a dependence between the presence of extractions and the development of MRONJ (p < 0.001) but not with the time elapsed from the initiation of infusions with BPs and dental extractions (p = 0.499). In the sample of patients with multiple myeloma (MM), 13.8% were found to be more likely to develop MRONJ after an extraction. Conclusions: The most common local predisposing factor was dental extraction. No dependence was observed between the development of osteonecrosis and the time elapsed from the beginning of treatment with bisphosphonates infusions to surgical procedures. Full article
(This article belongs to the Special Issue Potentially Malignant Disorders and Cancers of Head and Neck Region—Series 2)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop