Photobiomodulation Research and Applications in Dentistry

Dear Colleagues,

Photobiomodulation (PBM) is an emerging field of research that explores the application of low amounts of light, produced both either lasers or LED, to stimulate cellular processes and promote healing and tissues regeneration. In recent years, PBM has gained increasing interest within medicine and dentistry due to its numerous of applications that can improve patient outcomes in various procedures and conditions.

PBM was demonstrated to influence several cellular processes. Its action can lead to the activation of biochemical pathways, such as cytochrome c oxidase, a component of the mitochondrial respiratory chain, inducing an increase in ATP production, and leading to high cellular energy availability and viability. Moreover, PBM can modulate the production of reactive oxygen species (ROS) and nitric oxide, which play crucial roles in cellular signalling and other vital processes.

Extensive research has been conducted to clarify the underlying mechanisms and therapeutic potential of PBM in dentistry. Studies have shown that PBM can reduce pain and inflammation, enhancing wound healing and promoting tissue regeneration. The approach has shown also promising effects in stimulating the regeneration of both soft and hard tissues, including periodontal tissues and bone. Accordingly, its applications are increasing as research progresses.

However, even if PBM holds significant promise in dentistry, there are still challenges and areas that require further investigation, such as in standardizing treatment protocols, understanding optimal dosages, and identifying the most effective wavelengths for the various clinical conditions. Understanding the dose–response relationship and the optimal parameters for each disease will enhance the efficacy of PBM treatments and, in the meanwhile, will lead many practitioners to integrate it into their daily dental practice with beneficial effects for their patients.

Prof. Dr. Alessandro Del Vecchio
Dr. Francisco José Gomez Garcia
Dr. Luís Monteiro
Guest Editors

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• photobiomodulation (PBM)
• lasers
• LED
• cellular viability
• wound healing
• tissue regeneration
• pain reduction
• inflammation reduction
• bone regeneration
• therapeutic protocol
• dose–response