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Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA
Interests: brain Ischemia; intracranial large vessel occlusion stroke; thrombolytic therapy; stroke; vascular neurology; artificial intelligence

Special Issue Information

Dear Colleagues,

Novel techniques and treatment modalities are emerging in the fields of stroke, vascular neurology, and interventional neuroradiology. Recent research breakthroughs have changed our understanding of stroke pathophysiology, imaging, and treatments. In addition, artificial intelligence has revolutionized the management of acute stroke.

In this Special Issue of JCM, we will cover the following topics and updates in the fields of stroke, vascular neurology, and interventional neuroradiology:

Updates on acute thrombolytic therapy, with a focus on intravenous tenecteplase;
Updates on patient selection based on imaging modalities for intravenous thrombolytic therapy and mechanical thrombectomy;
Updates on the role of mechanical thrombectomy for medium- and small-size intracranial vessel occlusion;
Updates on the role of mechanical thrombectomy in large-vessel occlusion strokes with large core infarct;
Updates on the management of intracranial atherosclerotic disease;
Updates on the management of vertebral artery atherosclerotic steno-occlusive disease;
Application of AI in the detection and management of acute ischemic stroke;
Management of complications of mechanical thrombectomy.

Dr. Ashkan Mowla
Guest Editor

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Keywords

stroke
mechanical thrombectomy
intravenous thrombolytic therapy
imaging selection for stroke
large-vessel occlusion
intracranial atherosclerotic disease
artificial intelligence

Published Papers (1 paper)

Research

Open AccessArticle

Age Stratification and Stroke Severity in the Telestroke Network

Cassie A. Simmons

Nicolas Poupore

and

Thomas I. Nathaniel

J. Clin. Med. 2023, 12(4), 1519; https://doi.org/10.3390/jcm12041519 - 14 Feb 2023

Viewed by 497

Abstract

Background. Age is one of the most important risk factors for stroke, and an estimated 75% of strokes occur in people 65 years old and above. Adults > 75 years of age experience more hospitalizations and higher mortality. In this study, we aimed to investigate how age and various clinical risk factors affect acute ischemic stroke (AIS) severity in two age categories. Methods. This retrospective data analysis study was conducted using data collected from the PRISMA Health Stroke Registry between June 2010 and July 2016. Baseline clinical and demographic data were analyzed for 65–74-year-old patients and those ≥ 75 years of age. This study aimed to investigate risk factors associated with stroke severity in these two age categories of AIS patients treated in telestroke settings. Results. An adjusted multivariate analysis showed that the acute ischemic stroke (AIS) population of 65–74-year-old patients experiencing heart failure (odds ratio (OR) = 4.398, 95% CI = 3.912–494.613, p = 0.002) and elevated high-density lipoprotein (HDL) levels (OR = 1.066, 95% CI = 1.009–1.126, p = 0.024) trended towards worsening neurological function, while patients experiencing obesity (OR = 0.177, 95% CI = 0.041–0.760, p = 0.020) exhibited improved neurological functions. For the patients ≥ 75 years of age, direct admission (OR = 0.270, 95% CI = 0.085–0.856, p = 0.026) was associated with improved functions. Conclusions. Heart failure and elevated HDL levels were significantly associated with worsening neurologic functions in patients aged 65–74. Obese patients and individuals ≥ 75 years of age who were directly admitted were most likely to exhibit improving neurological functions. Full article

(This article belongs to the Special Issue Advances in the Diagnosis, Treatment, and Prognosis of Acute Stroke)

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Special Issue "Advances in the Diagnosis, Treatment, and Prognosis of Acute Stroke"

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