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5 August 2025
Journal of Clinical Medicine | Highly Cited Papers and Hot Topic Special Issues on Stroke


Stroke is an acute nervous system disease caused by a variety of factors, such as cerebral vascular damage and focal or whole brain damage, and it has become a threat to global health. At present, medical research is deeply involved in the fields of early detection and timely intervention of stroke, prognosis management, and rehabilitation intervention, which injects new impetus into helping patients recover their functions, reduce recurrence, and improve their quality of life. We welcome you to read the following highly cited papers published in the Journal of Clinical Medicine (JCM, ISSN: 2077-0383), and hope that these articles can bring new ideas for stroke research. In addition, some Special Issues on this topic are currently open for submission.

1. “The Impact of Anti-Amyloid Immunotherapies on Stroke Care”
by Philippe A. Bilodeau, John R. Dickson and Mariel G. Kozberg
J. Clin. Med. 2024, 13(5), 1245; https://doi.org/10.3390/jcm13051245
Full text available online: https://www.mdpi.com/2077-0383/13/5/1245

2. “Sex-Related Differences in Mortality, Delayed Cerebral Ischemia, and Functional Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis”
by Sarah Berli, Massimo Barbagallo, Emanuela Keller, Giuseppe Esposito, Alberto Pagnamenta and Giovanna Brandi
J. Clin. Med. 2024, 13(10), 2781; https://doi.org/10.3390/jcm13102781
Full text available online: https://www.mdpi.com/2077-0383/13/10/2781

3. “Benefits of Robot-Assisted Upper-Limb Rehabilitation from the Subacute Stage after a Stroke of Varying Severity: A Multicenter Randomized Controlled Trial”
by So Young Ahn, Soo-Kyung Bok, Ji Young Lee, Hyeon Woo Ryoo, Hoo Young Lee, Hye Jung Park, Hyun Mi Oh and Tae-Woo Kim
J. Clin. Med. 2024, 13(3), 808; https://doi.org/10.3390/jcm13030808
Full text available online: https://www.mdpi.com/2077-0383/13/3/808

4. “Blood Pressure Variability in Acute Stroke: A Narrative Review”
by Christina Zompola, Lina Palaiodimou, Konstantinos Voumvourakis, Leonidas Stefanis, Aristeidis H. Katsanos, Else C. Sandset, Estathios Boviatsis and Georgios Tsivgoulis
J. Clin. Med. 2024, 13(7), 1981; https://doi.org/10.3390/jcm13071981
Full text available online: https://www.mdpi.com/2077-0383/13/7/1981

5. “Effectiveness of Virtual Reality in Occupational Therapy for Post-Stroke Adults: A Systematic Review”
by Síbila Floriano Landim, Roberto López, Antonia Caris, Constanza Castro, Ramon D. Castillo, Daniela Avello, Braulio Henrique Magnani Branco, Pablo Valdés-Badilla, Florencia Carmine, Cristian Sandoval et al.
J. Clin. Med. 2024, 13(16), 4615; https://doi.org/10.3390/jcm13164615
Full text available online: https://www.mdpi.com/2077-0383/13/16/4615

6. “Flow Diversion for Endovascular Treatment of Intracranial Aneurysms: Past, Present, and Future Directions”
by Michael Gaub, Greg Murtha, Molly Lafuente, Matthew Webb, Anqi Luo, Lee A. Birnbaum, Justin R. Mascitelli and Fadi Al Saiegh
J. Clin. Med. 2024, 13(14), 4167; https://doi.org/10.3390/jcm13144167
Full text available online: https://www.mdpi.com/2077-0383/13/14/4167

7. “A Long-Term Comparative Analysis of Endovascular Coiling and Clipping for Ruptured Cerebral Aneurysms: An Individual Patient-Level Meta-Analysis Assessing Rerupture Rates”
by Johannes Wach, Martin Vychopen, Agi Güresir, Alexandru Guranda, Ulf Nestler and Erdem Güresir
J. Clin. Med. 2024, 13(6), 1778; https://doi.org/10.3390/jcm13061778
Full text available online: https://www.mdpi.com/2077-0383/13/6/1778

8. “Influence of High-Intensity Interval Training on Neuroplasticity Markers in Post-Stroke Patients: Systematic Review”
by Gines Montero-Almagro, Carlos Bernal-Utrera, Noelia Geribaldi-Doldán, Pedro Nunez-Abades, Carmen Castro and Cleofas Rodriguez-Blanco
J. Clin. Med. 2024, 13(7), 1985; https://doi.org/10.3390/jcm13071985
Full text available online: https://www.mdpi.com/2077-0383/13/7/1985

9. “Stroke in Young Adults”
by Syed Bukhari, Shadi Yaghi and Zubair Bashir
J. Clin. Med. 2023, 12(15), 4999; https://doi.org/10.3390/jcm12154999
Full text available online: https://www.mdpi.com/2077-0383/12/15/4999

10. “Age Stratification and Stroke Severity in the Telestroke Network”
by Cassie A. Simmons, Nicolas Poupore and Thomas I. Nathaniel
J. Clin. Med. 2023, 12(4), 1519; https://doi.org/10.3390/jcm12041519
Full text available online: https://www.mdpi.com/2077-0383/12/4/1519

 Special Issues:

Recent Advances in Intracranial Aneurysm Treatment
Guest Editor: Dr. Victor Volovici
Submission deadline: 25 November 2025

Neurovascular Diseases: Clinical Advances and Challenges
Guest Editors: Dr. Roberto Colasanti; Dr. Silky Chotai; Dr. Alessandro Di Rienzo and Dr. Joham Choque-Velasquez
Submission deadline: 25 November 2025

Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke
Guest Editor: Prof. Dr. Fusao Ikawa
Submission deadline: 20 January 2026

Revolutionizing Neurosurgery: Cutting-Edge Techniques and Innovations
Guest Editor: Dr. Yoichi Morofuji
Submission deadline: 31 January 2026

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