Personalized AI: Machine Learning for Tailored Interventions in Medicine and Education

A special issue of Information (ISSN 2078-2489). This special issue belongs to the section "Artificial Intelligence".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 2322

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Special Issue Information

Dear Colleagues,

The era of one-size-fits-all solutions is rapidly giving way to a new paradigm of personalization, driven by breakthroughs in Artificial Intelligence and Machine Learning. Two domains at the forefront of this revolution are medicine and education, where the potential to tailor interventions to individual needs promises unprecedented improvements in outcomes. In medicine, this translates to precision treatments based on a patient's unique genetic and lifestyle profile. In education, it means creating adaptive learning paths that cater to a student's specific knowledge gaps and learning pace.

While these fields often advance in parallel, they share a deep-seated foundation in common ML methodologies—from reinforcement learning for dynamic policy-making to recommendation engines for content delivery. This Special Issue, "Personalized AI: Machine Learning for Tailored Interventions in Medicine and Education," aims to bridge the gap between these two critical domains. We seek to foster a cross-disciplinary dialogue, highlighting shared challenges and synergistic solutions in the development of sophisticated, human-centric personalized systems. 

We invite the submission of high-quality, original research articles, reviews, and communications that explore the theory, application, and impact of personalized AI. Topics of interest include, but are not limited to, the following:

Machine Learning for Personalized Medicine:

  • Precision medicine: Patient-specific diagnosis, prognosis, and treatment planning.
  • AI-driven drug discovery and repurposing for individual patient profiles.
  • Adaptive clinical trials and personalized dosing algorithms.
  • Predictive models for patient-specific risk stratification.
  • Personalized digital health coaching and remote monitoring systems.
  • NLP for extracting personalized insights from electronic health records (EHRs).

Machine Learning for Personalized Education:

  • Intelligent Tutoring Systems (ITSs) and AI-powered educational guides.
  • Adaptive learning platforms that dynamically adjust content and difficulty.
  • Educational Data Mining (EDM) for granular student modeling and knowledge tracing.
  • Personalized and gamified learning environments to enhance engagement.
  • Automated, individualized feedback and assessment systems.
  • Recommendation systems for educational resources and learning pathways.

Cross-Cutting Methodologies and Considerations:

  • Reinforcement learning for optimizing sequential personalized interventions.
  • Explainable AI (XAI) to ensure transparency and trust in personalized models.
  • Federated and privacy-preserving learning for sensitive personal data.
  • Causal inference for evaluating the effectiveness of personalized strategies.
  • Ethical frameworks, fairness, and bias mitigation in personalized AI.

Dr. Dimitrios Karapiperis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Information is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized AI
  • machine learning
  • medicine
  • education
  • reinforcement learning
  • explainable AI (XAI)

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Published Papers (2 papers)

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Research

33 pages, 9132 KB  
Article
Leveraging Feature Selection and Ensemble Learning to Predict Secondary School Achievement: A Comparative Study of Three Grade Granularities
by Dimitrios Galiatsatos and Panagiota Galiatsatou
Information 2026, 17(6), 517; https://doi.org/10.3390/info17060517 - 22 May 2026
Viewed by 235
Abstract
Predictive analytics has become increasingly important in educational decision-making, supporting at-risk identification and adaptive tutoring. The accurate early prediction of school achievement can enable timely intervention. Using the Math Students dataset, which contains data on students from two Portuguese secondary schools, we model [...] Read more.
Predictive analytics has become increasingly important in educational decision-making, supporting at-risk identification and adaptive tutoring. The accurate early prediction of school achievement can enable timely intervention. Using the Math Students dataset, which contains data on students from two Portuguese secondary schools, we model three categorical outcomes derived from the students’ final grade, namely the final grade level (low, medium, high), its qualitative evaluation (fail, satisfactory, good, excellent), and the final pass/fail outcome. After preprocessing, three filter methods—Correlation-Based Feature Subset Selection (CFS), Correlation Attribute Evaluation (CorrEval), and Information Gain (InfoGain)—are applied to reduce the dimensionality of the datasets. Nine classifiers (Naive Bayes, Logistic, MLP, SMO, IBk, Bagging, J48, Random Forest, Random Tree) are evaluated using ten-fold cross-validation in the Waikato Environment for Knowledge Analysis (Weka) platform. Random Forest with InfoGain achieves 90.7% accuracy on the three-band task, while Bagging with InfoGain achieves 92.5% on the binary pass/fail outcome, outperforming benchmarks in prior Educational Data Mining (EDM) studies. Results confirm that prior academic performance indicators (first- and second-period grades) and failure history dominate predictive power and contribute substantially to the success of ensemble models, particularly when paired with feature selection methods that reduce noise and highlight relevant attributes. Full article
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31 pages, 3311 KB  
Article
DK-PRACTICE: An Intelligent Platform for Knowledge Tracing and Educational Content Recommendation: A Case Study in Higher Education
by Marina Delianidi, Konstantinos Diamantaras, Georgios Kokkonis, Antonis Sidiropoulos, Georgios Evangelidis and Dimitrios Karapiperis
Information 2026, 17(2), 202; https://doi.org/10.3390/info17020202 - 15 Feb 2026
Viewed by 1406
Abstract
This paper introduces DK-PRACTICE, an intelligent educational platform that combines Knowledge Tracing (KT) and recommendation systems to support personalized learning in higher education. The platform utilizes a novel Paired Bipolar Bag-of-Words (PB-BoW) model to assess students’ knowledge states, forecast performance, and offer targeted [...] Read more.
This paper introduces DK-PRACTICE, an intelligent educational platform that combines Knowledge Tracing (KT) and recommendation systems to support personalized learning in higher education. The platform utilizes a novel Paired Bipolar Bag-of-Words (PB-BoW) model to assess students’ knowledge states, forecast performance, and offer targeted recommendations. To test its effectiveness in real-world settings, DK-PRACTICE was implemented in the “Computer Organization and Architecture” undergraduate course, involving 138 students in Pre-Test and 106 in Post-Test. Empirical analysis of benchmark datasets and a newly created course dataset showed that the PB-BoW model outperformed an RNN-based KT model in predictive accuracy. Student surveys indicated high levels of satisfaction with usability, relevance of recommendations, and overall learning support, with most participants expressing willingness to reuse the platform in other courses. These results demonstrate the potential of DK-PRACTICE as a scalable and adaptable tool for improving personalized learning and bridging the gap between AI-driven KT research and classroom implementation. Full article
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