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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitochondrial Function in Human Health and Disease: 2nd Edition

edited by

Yumay Chen

submission deadline 20 Jul 2025 | 4 articles | Viewed by 5299 | Submission Open

Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Biochemistry)

Bioinformatics Study in Human Diseases: Integration of Omics Data for Personalized Medicine (Second Edition)

edited by

Hung-Yu Lin

and

Pei-Yi Chu

submission deadline 20 Jul 2025 | 5 articles | Viewed by 5251 | Submission Open

Keywords: cancers; ageing-related diseases; bioinformatics; multi-omics; pharmacogenetics; deep learning; evolutionary learning; diagnosis; prognosis; companion biomarker; drug screening; mechanism dissection

(This special issue belongs to the Section Molecular Informatics)

Molecular Research and Cellular Biology of Breast Cancer

edited by

Andrea Nicolini

and

Cristian Scatena

submission deadline 20 Jul 2025 | 6 articles | Viewed by 5167 | Submission Open

Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor immune responses; conventional and biological therapies; blood and tissue biomarkers

(This special issue belongs to the Section Molecular Oncology)

Abiotic Stresses in Plants: From Molecules to Environment—2nd Edition

edited by

Martin Bartas

submission deadline 20 Jul 2025 | 4 articles | Viewed by 5152 | Submission Open

Keywords: stress signaling; abiotic stress; oxidative stress; genotoxic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Chromatin Remodelers as Players and Drivers in Pathological States

edited by Matteo De March

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5057 | Submission Open

Keywords: protein structure/function; chromatin remodelers; DNA repair; oncogene/oncosuppressor; cancer

(This special issue belongs to the Section Molecular Biology)

Molecular Linkage between Atherosclerosis and Extracellular Vesicles

edited by

Wioletta Olejarz

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4990 | Submission Open

Keywords: atherosclerosis; extracellular vesicles; exosomes; vascular inflammation; stroke; biomarkers; miRNA; stem and progenitor cells; cardiovascular diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic Research of Rare Diseases

edited by Shira Rockowitz and Piotr Sliz

submission deadline 20 Jul 2025 | 5 articles | Viewed by 4965 | Submission Open

Keywords: rare disease ontology; variants of uncertain significance; candidate genes; whole genome sequencing; long read whole genome sequencing; machine learning; multi-omics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Application of Biomolecular Materials in Tissue Engineering

edited by

István Hornyák

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4958 | Submission Open

Keywords: biomolecular materials; tissue engineering; material science; in vitro and in vivo biodegradation; cell culture; tissue regeneration; cell scaffold; biocompatible materials

(This special issue belongs to the Section Materials Science)

Lung Diseases Molecular Pathogenesis and Therapy

edited by

Kazufumi Nakamura

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4957 | Submission Open

Keywords: lung diseases; drug therapy; chronic obstructive pulmonary disease; lung cancer; lung fibrosis; pulmonary hypertension; asthma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Obstructive Pulmonary Disease (COPD): From Pathogenesis to Therapy

edited by José M. Marin

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4941 | Submission Open

Keywords: COPD; COPD mechanisms; COPD pathology; COPD pharmacology; cytokine biology; biomarkers; early diagnosis; inflammation; COPD management; new therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Animal Research Model for Neurological Diseases, 2nd Edition

edited by

Giuseppe Montalbano

and

Sepand Rastegar

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4904 | Submission Open

Keywords: experimental models; mouse; rat; zebrafish; neurological disease; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; neuroregeneration

(This special issue belongs to the Section Molecular Neurobiology)

Understanding Reproductive Health and Infertility: Molecular and Genetic Insights

edited by

Jan Tesarik

submission deadline 20 Jul 2025 | 4 articles | Viewed by 4836 | Submission Open

Keywords: sperm quality; oocyte quality; uterine receptivity

(This special issue belongs to the Section Molecular Biology)

The Role of Glia in Neuropsychiatric Disorders

edited by

Guillaume Lucas

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4761 | Submission Open

Keywords: glial cells; astrocytes; microglia; neuro-inflammation; synaptic plasticity; neuropsychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Prevention, Diagnosis and Treatment of Pediatric Diseases

edited by

Giovanni Fiorito

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4722 | Submission Open

Keywords: pediatric diseases; bioinformatics; in utero and early-life exposures; multi-omic biomarkers; personalized medicine; diagnosis; prevention

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Role of Non-coding RNAs in Cancer: Inside and outside Cells

edited by

Simone Anfossi

and

Linda Fabris

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4696 | Submission Open

Keywords: ncRNAs; gene expression regulation; biological functions; extracellular vesicles; intercellular communication; cancer progression; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Inflammatory Signaling Pathways Involved in Gastrointestinal Diseases: Second Edition

edited by

Diana Di Liberto

and

Marianna Lauricella

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4687 | Submission Open

Keywords: inflammatory signaling pathways; gastrointestinal diseases; gastrointestinal cancer; inflammatory bowel disease; colonitis; colorectal cancer; cytokine

(This special issue belongs to the Section Molecular Immunology)

Advances in Density Functional Theory and Related Methods for Molecular Computational Chemistry

edited by Paolo Umari

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4580 | Submission Open

Keywords: density functional theory; quantum chemistry; algorithms; quantum computing; high-performance computing; machine learning; many-body perturbations theory; quantum Monte Carlo

(This special issue belongs to the Section Molecular Informatics)

Signaling Pathways and Novel Therapies in Heart Disease

edited by

Anindita Das

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4567 | Submission Open

Keywords: heart failure; arrhythmias; ischemic heart disease; myocardial regeneration; inflammation; gene- or cell-based therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Basis of Autism Spectrum Disorder

edited by

Elisabetta Bolognesi

and

Franca Rosa Guerini

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4547 | Submission Open

Keywords: autism spectrum disorder (ASD); neurodevelopmental disorder (NDD); genetic causes of autism; genetic polymorphism; gene variant; genome-wide association studies; single nucleotide; polymorphism; precision medicine; genetic mutations; diagnostic marker

(This special issue belongs to the Section Molecular Genetics and Genomics)

Marine Omics

edited by

Mónica Carrera

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4515 | Submission Open

Keywords: marine; seafood; omics; genomics; proteomics; transcriptomics; metabolomics; systems biology

(This special issue belongs to the Section Biochemistry)

NRF2/KEAP1 Signalling in Cancer

edited by

Sonia Fantone

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4455 | Submission Open

Keywords: oxidative stress; cancer; aging; senescence; inflammation; ovarian cancer; prostate cancer; antioxidants

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders

edited by Marta Pardo

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4437 | Submission Open

Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets

(This special issue belongs to the Section Molecular Neurobiology)

Peroxisome and Lysosome in Health and Disease

edited by

Anne Vejux

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4435 | Submission Open

Keywords: peroxisomes; lysosomes; autophagy; lysosomal diseases; peroxidase; oxidative stress; acid hydrolase; lysosomal storage disease(LSD); gaucher disease

(This special issue belongs to the Section Molecular Biology)

Plasticity of the Nervous System after Injury: 2nd Edition

edited by

Xavier Navarro

and

Tessa Gordon

submission deadline 20 Jul 2025 | 4 articles | Viewed by 4432 | Submission Open

Keywords: neural plasticity; axonal regeneration; nerve injury; glial cells; central nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research on Hypertension and Related Complications

edited by

Marijn Speeckaert

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4353 | Submission Open

Keywords: arterial hypertension; cardiovascular disease; pathophysiology; molecular mechanisms; complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathways in Development and Disease: The Role of RNA Regulation in Biological and Pathological Events

edited by

Guilherme Tralhão

and

Rui Caetano Oliveira

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4350 | Submission Open

Keywords: RNA; human disease; cancer; diagnostic; therapy; development

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Zoology

edited by

Valeria Maselli

submission deadline 20 Jul 2025 | 4 articles | Viewed by 4347 | Submission Open

Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoolog

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Forensic Pathology and Toxicology: An Update

edited by

Angelo Montana

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4313 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Transporters in Health and Disease

edited by

Giuliano Ciarimboli

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4228 | Submission Open

Keywords: transporters; disease; regulation; drugs; toxicity; signaling

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Functions of Macrophage Cells

edited by Magdalena Król

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4143 | Submission Open

Keywords: macrophages; immune responses; inflammation; cancer; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Electrochemical-Related Materials

edited by Celia García-Hernandez

submission deadline 20 Jul 2025 | 4 articles | Viewed by 4140 | Submission Open

Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications

(This special issue belongs to the Section Materials Science)

The Role of RNAs in Cancers: Recent Advances

edited by Roman Beňačka

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4133 | Submission Open

Keywords: cancer cells; carcinogenesis; mRNAs; ncRNAs; lncRNAs; miRNAs; circRNAs; piRNAs; RNA-based diagnostics; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Agro-Polymers

edited by

In Chul Um

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4119 | Submission Open

Keywords: cellulose; lignin; starch; fibroin; sericin; keratin; soy; zein; pectin; collagen; biocompatibility; biodegradability

(This special issue belongs to the Section Materials Science)

Integrative Multi-Omics Analysis for Cancer Biomarkers

edited by

Youping Deng

and

Kurt K. Zhang

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4118 | Submission Open

Keywords: bioinformatics; biomedical informatics; cancer; genomics; systems biology

(This special issue belongs to the Section Molecular Oncology)

New Insights into Plant Pathology and Abiotic Stress

edited by

Shoupu He

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4111 | Submission Open

Keywords: plant pathology; abiotic stress; molecular mechanisms; stress resistance; signaling pathways; epigenetics; omics technologies; disease management; climate change; plant stress responses

(This special issue belongs to the Section Molecular Plant Sciences)

Vegetable Genetics and Genomics, 3rd Edition

edited by

Yunsong Lai

and

Xixiang Li

submission deadline 20 Jul 2025 | 4 articles | Viewed by 4049 | Submission Open

Keywords: major vegetable crops; genome; variome; genotyping; GWAS; QTL mapping; functional genome; metabolome; breeding target characters; genetic mechanism; functional genes

(This special issue belongs to the Section Molecular Plant Sciences)

Pediatric Diseases: From Molecular Mechanisms to Novel Therapeutic Strategies

edited by

Elena Tarca

submission deadline 20 Jul 2025 | 3 articles | Viewed by 4006 | Submission Open

Keywords: congenital abnormalities; genetic disease; molecular mechanism; therapeutic agents; maternal and fetal medicine; pediatric diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by Lorenzo Belluomini

submission deadline 20 Jul 2025 | 2 articles | Viewed by 3957 | Submission Open

Keywords: NSCLC; predictive and prognostic biomarkers; immunotherapy; targeted therapy; special populations

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Discovery of Microbial and Plant Specialized Metabolites

edited by

Marco Masi

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3932 | Submission Open

Keywords: natural products; specialized metabolites; secondary metabolites; plant; pharmacology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Toxicity of Foodstuff Contaminants and Mitigation Strategies

edited by

Lihong Zhao

and Matthew Koci

submission deadline 20 Jul 2025 | 2 articles | Viewed by 3923 | Submission Open

Keywords: antibiotics; heavy metals; pesticides; mycotoxins; foodborne pathogens; polycyclic aromatic hydrocarbons; microplastics; toxicity; biodegradation; detoxification

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors

edited by

Emily Capone

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3894 | Submission Open

Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design

(This special issue belongs to the Section Molecular Oncology)

New Insights into the Immunopathology of Infectious Diseases

edited by Marta Camici

submission deadline 20 Jul 2025 | 2 articles | Viewed by 3831 | Submission Open

Keywords: infection immunology; immune dysregulation in infectious diseases; interactions between infective agents and immune responses; modeling of the immune system; new pathways of pathogenesis

(This special issue belongs to the Section Molecular Immunology)

New Insights into Immune Dysregulation Disorders

edited by

Francesco Saettini

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3784 | Submission Open

Keywords: immune dysregulation disorders; autoimmune conditions; primary immunodeficiencies; autoinflammatory disorders

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of Osteoporosis

edited by

Harish K. Datta

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3782 | Submission Open

Keywords: osteoporosis; bone; signalling; molecular; fractures; endocrine; paracrine

(This special issue belongs to the Section Molecular Biology)

Novel Insights into Regenerative Medicine

edited by

Jorge U. Carmona

and

Marco Tatullo

submission deadline 20 Jul 2025 | 2 articles | Viewed by 3734 | Submission Open

Keywords: regenerative medicine; tissue regeneration; stem cell; platelet-rich plasma; growth factors; cytokines; bioscaffolds; gels

(This special issue belongs to the Section Materials Science)

Beyond Digestion: The Role of Gut Microbiota in Metabolism, Immunity and Brain Function

edited by

Alip Borthakur

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3719 | Submission Open

Keywords: gut dysbiosis; gut microbiota; metabolism

(This special issue belongs to the Section Molecular Immunology)

Biomaterials for Drug Delivery and Advanced Therapies

edited by

Annalisa Bianchera

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3714 | Submission Open

Keywords: polymers; biomaterials; drug delivery; scaffold; ATMPs; tissue regeneration

(This special issue belongs to the Section Materials Science)

Molecular Research on Amyloidosis in Pathobiology and Therapy

edited by

Kazufumi Nakamura

submission deadline 20 Jul 2025 | 1 articles | Viewed by 3681 | Submission Open

Keywords: amyloidosis; ATTR; transthyretin; misfolding; molecular mechanisms; molecular therapeutic targets; molecular imaging; SPECT; tracers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances, Pitfalls and Future Perspectives for CRISPR/Cas9 Mediated Genome Editing: 4th Edition

edited by

Alexander Kondrashov

and

Timofey S. Rozhdestvensky

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3634 | Submission Open

Keywords: molecular insights into different approaches and methods for CRISPR/Cas9 genome editing; the generation of disease models; the CRISPR/Cas9-mediated genome editing of ES cells; the CRISPR/Cas9 system in cancer biology; CRISPR/Cas9-mediated genome editing in model organisms (plants; fungi and animals); the CRISPR/Cas9 system in epigenetic research; the CRISPR/Cas9 system in gene therapy— applications and the challenges in the implementation of this technology; the CRISPR/Cas9 system beyond genome editing (molecular markers; biosensors; etc.)

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Human Retrovirus Infection: 2nd Edition

edited by

Yosuke Maeda