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Recent Advances in Discovery of Microbial and Plant Specialized Metabolites

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 517

Special Issue Editor

Department of Chemical Sciences, University of Naples Federico II, Naples, Italy
Interests: natural products; secondary metabolites; bioactive compounds; spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Specialized metabolites, or secondary metabolites, are compounds produced by different organisms that are not directly involved in the primary metabolic processes necessary for growth, development, and reproduction. These natural products often play specific roles in interactions with the environment, defense mechanisms, and communication. They belong to different chemical classes such as alkaloids, terpenoids, phenolic compounds, flavonoids, polyketides and glycosides. Specialized metabolites can influence the growth and development of neighboring organisms through allelopathy. Some plants release chemicals into the soil to inhibit the growth of competing plants, helping them establish dominance in a particular area. Many pharmaceuticals and drugs are also derived from natural compounds. In fact, plants, fungi, and bacteria are able to produce metabolites with potential medicinal properties that have been exploited for various therapeutic purposes. Understanding and studying specialized metabolites are crucial in fields such as pharmacology, agriculture, food production and ecology, as they play essential roles in various biological processes and interactions within ecosystems. Therefore, this Special Issue will report advancements in the isolation and chemical and biological characterization of both microbial and plant specialized metabolites.

Dr. Marco Masi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • natural products
  • specialized metabolites
  • secondary metabolites
  • plant
  • pharmacology

Published Papers (1 paper)

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Research

17 pages, 3784 KiB  
Article
Health-Promoting Properties of Natural Flavonol Glycosides Isolated from Staphylea pinnata L.
by Ida Paolillo, Giuseppina Roscigno, Michele Innangi, Jesús G. Zorrilla, Gianmarco Petraglia, Maria Teresa Russo, Federica Carraturo, Marco Guida, Alessandra Pollice, Alessio Cimmino, Marco Masi and Viola Calabrò
Int. J. Mol. Sci. 2024, 25(11), 5582; https://doi.org/10.3390/ijms25115582 - 21 May 2024
Viewed by 395
Abstract
Staphylea, also called bladdernuts, is a genus of plants belonging to the family Staphyleaceae, widespread in tropical or temperate climates of America, Europe, and the Far East. Staphylea spp. produce bioactive metabolites with antioxidant properties, including polyphenols which have not been completely [...] Read more.
Staphylea, also called bladdernuts, is a genus of plants belonging to the family Staphyleaceae, widespread in tropical or temperate climates of America, Europe, and the Far East. Staphylea spp. produce bioactive metabolites with antioxidant properties, including polyphenols which have not been completely investigated for their phytotherapeutic potential, even though they have a long history of use for food. Here, we report the isolation of six flavonol glycosides from the hydroalcoholic extract of aerial parts of Staphylea pinnata L., collected in Italy, using a solid-phase extraction technique. They were identified using spectroscopic, spectrometric, and optical methods as three quercetin and three isorhamnetin glycosides. Among the flavonol glycosides isolated, isoquercetin and quercetin malonyl glucoside showed powerful antioxidant, antimicrobial, and wound healing promoting activity and thus are valuable as antiaging ingredients for cosmeceutical applications and for therapeutic applications in skin wound repair. Full article
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