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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Research on Neurotransmitters

edited by

Mario Manto

Hiroshi Mitoma

and Jing-Ning Zhu

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9294 | Submission Open

Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Organic/Inorganic Nanocomposites on the Basis of 'Three Pillars' (Organic Compounds, Metal Nanoparticles, and Carbon Nanomaterials)

edited by

Tamara Basova

submission deadline 20 Jul 2025 | 7 articles | Viewed by 9233 | Submission Open

Keywords: organic/inorganic composites; hybrid materials; composite materials; organic films; polymers; aromatic molecules; metal nanoparticles; carbon nanomaterials; carbon nanotubes; graphene

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mediators of Exercise: Cross-Organ Communication Promoting Health and Combating Disease

edited by

Jan Bilski

and

Tomasz Brzozowski

submission deadline 20 Jul 2025 | 4 articles | Viewed by 9233 | Submission Open

Keywords: exercise physiology; adipokines; myokines; hepatokines; inter-organ communication; inflammation; insulin sensitivity; obesity; type 2 diabetes; gastrointestinal system; cardiovascular system; sarcopenia; aging; osteogenic regulation; neurological health; nutraceuticals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metal-Based Drugs and Research on Mechanisms of Action

edited by

Elena K. Beloglazkina

submission deadline 20 Jul 2025 | 3 articles | Viewed by 8932 | Submission Open

Keywords: transition metals; metal complexes; metallodrugs; drug development; synthesis; imaging agents; structure– activity ratio

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Kidney Injury and Repair

edited by

Rossana Franzin

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8882 | Submission Open

Keywords: kidney injury; renal repair; acute kidney injury (AKI); chronic kidney disease (CKD); sepsis; ischemia-reperfusion (I/R) injury; nephrotoxin exposition; adult renal progenitor cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition

edited by

Catherine Davis

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8770 | Submission Open

Keywords: vascular permeability; atherosclerosis; blood– brain barrier; endothelial adhesion molecules; vasodilation; thrombosis

(This special issue belongs to the Section Molecular Immunology)

Functional Roles of Epithelial and Endothelial Cells

edited by

Lucie Germain

and

Stéphanie Proulx

submission deadline 20 Jul 2025 | 7 articles | Viewed by 8723 | Submission Open

Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier

(This special issue belongs to the Section Biochemistry)

Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy

edited by

Arnau Panisello-Roselló

and Emma Folch-Puy

submission deadline 20 Jul 2025 | 4 articles | Viewed by 8412 | Submission Open

Keywords: hepatopancreatic diseases; intestine diseases; molecular basis; therapy; pathogenesis; molecular pathways; pharmacological interventions; surgical techniques; immunotherapies; regenerative medicine approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Challenges and Future Perspectives in Treatment for Lung Cancer

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 20 Jul 2025 | 7 articles | Viewed by 8388 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery

(This special issue belongs to the Section Molecular Oncology)

Novel Insight into Epigenomic Studies of Human Disease

edited by

Mitsuko Masutani

and Takashi Ito

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8326 | Submission Open

Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

A Molecular Perspective on Reproductive Health, 2nd Edition

edited by

Maria Montserrat Rivera Del Álamo

submission deadline 20 Jul 2025 | 4 articles | Viewed by 8317 | Submission Open

Keywords: reproductive function; molecular bases; male; female; reproductive pathology; reproductive physiology

(This special issue belongs to the Section Biochemistry)

Natural Products in Cancer Prevention and Treatment

edited by

Simona Serini

and

Gabriella Calviello

submission deadline 20 Jul 2025 | 7 articles | Viewed by 8229 | Submission Open

Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Lung Cancer

edited by

Bassam Redwan

submission deadline 20 Jul 2025 | 3 articles | Viewed by 8149 | Submission Open

Keywords: lung cancer; immunotherapy; molecular diagnostic; next-generation sequencing

(This special issue belongs to the Section Molecular Oncology)

Versatility of Protein Synthesis in a Test Tube

edited by

Tamás Mészáros

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8104 | Submission Open

Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation

(This special issue belongs to the Section Molecular Biology)

Viral Infections and Host Immune Responses

edited by

Barbara Ridolfi

and Maria Teresa Maggiorella

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8093 | Submission Open

Keywords: virus infections; virus– host interaction; innate immunity; adaptive immunity; host factors; co-infections; acute and chronic infections; restriction factors; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

Prostate Cancer: Novel Research and Innovative Therapeutic Strategies

edited by

Giovanni Luca Beretta

submission deadline 20 Jul 2025 | 4 articles | Viewed by 8057 | Submission Open

Keywords: prostate cancer; therapeutic strategy; castration-resistant PCa

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glycobiology in Human Health and Disease

edited by Katrin Mani

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8017 | Submission Open

Keywords: glycans and glycoconjugates; glycoproteins; proteoglycans; glycolipids; glycosylation including glycosyltransferases and glycosidases; carbohydrate and glycan metabolism; glycan structure; disease biomarkers; glycan signaling; glycoimmunology; glycomics

(This special issue belongs to the Section Macromolecules)

A Molecular Perspective on the Genetics of Kidney Diseases

edited by Joaquim Calado

submission deadline 20 Jul 2025 | 4 articles | Viewed by 7948 | Submission Open

Keywords: kidney; genetics; solute transport; genomics; inflammation; dysmetabolism

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cutting-Edge Research and Applications of Extracellular Microvesicles in Disease Management

edited by María Isabel Torres

submission deadline 20 Jul 2025 | 5 articles | Viewed by 7915 | Submission Open

Keywords: extraccellular microvesicles; exosome; ectosoma; biomarkers; cargoes of extracellular vesicles; therapeutics; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Biomedical and Tissue Engineering Strategies to Cross the Blood–Brain Barrier for Next-Generation Treatments Against Neurodegenerative Diseases

edited by

Manuele Gori

and Livia La Barbera

submission deadline 20 Jul 2025 | 5 articles | Viewed by 7901 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; CNS; blood– brain barrier; drug delivery systems; nanocarriers; nanomedicine; tissue engineering; theranostics

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Protein–Ligand Interactions

edited by Dong-Jun Yu

submission deadline 20 Jul 2025 | 4 articles | Viewed by 7895 | Submission Open

Keywords: drug design; binding specificity; molecular docking; ligand screening; structural biology; protein– protein interactions; protein– ligand interactions; protein– lipid complexes; protein– nucleic acid interactions

(This special issue belongs to the Section Macromolecules)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Jul 2025 | 4 articles | Viewed by 7877 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Cardiovascular Diseases: Histopathological and Molecular Diagnostics

edited by

Simona Gurzu

submission deadline 20 Jul 2025 | 6 articles | Viewed by 7684 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress of Opioid Research, 2nd Edition

edited by

Soichiro Ide

and

Kazutaka Ikeda

submission deadline 20 Jul 2025 | 5 articles | Viewed by 7630 | Submission Open

Keywords: opioids; opioid crisis; pain; analgesic; addiction; dependence; stress; reward; opioid peptides; opioid use disorder

(This special issue belongs to the Section Molecular Pharmacology)

Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 20 Jul 2025 | 4 articles | Viewed by 7568 | Submission Open

Keywords: biogenic amines (histamine; dopamine; serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery

edited by Fei Guo

submission deadline 20 Jul 2025 | 6 articles | Viewed by 7497 | Submission Open

Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications

(This special issue belongs to the Section Molecular Informatics)

Molecular Metabolisms in Cartilage Health and Diseases: 3rd Edition

edited by

Masaharu Takigawa

submission deadline 20 Jul 2025 | 5 articles | Viewed by 7151 | Submission Open

Keywords: cartilage; chondrocytes; growth; regeneration; endochondral ossification; arthritis; joint; growth factors; mechanical stress; nutrition

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Hormone Signaling in Human Health and Diseases, 2nd Edition

edited by

Antonella Muscella

submission deadline 20 Jul 2025 | 5 articles | Viewed by 7132 | Submission Open

Keywords: hormone; cell receptor; endocrine signaling; cancer; insulin; oestrogen; testosterone; angiotensin; gonadotropin; thyroid hormone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Advances in Molecular Mechanisms Underlying Kidney Diseases: Pathophysiology and Therapeutic Targets, 2nd Edition

edited by

George J. Dugbartey

submission deadline 20 Jul 2025 | 4 articles | Viewed by 7015 | Submission Open

Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Breakthroughs in Molecular Diagnostic Tools for Human Diseases

edited by

Vittorio Fineschi

and

Aniello Maiese

submission deadline 20 Jul 2025 | 5 articles | Viewed by 6896 | Submission Open

Keywords: molecular pathology; molecular diagnostics; genetics; epigenetics; proteomics; immunohistochemistry; thrombo-embolic disease; sudden cardiac death; molecular pathology of traumatic injuries; hypoxic– ischemic brain damage; experimental models of injury and diseases; targeted therapy of injuries and diseases; drug abuse; histological diagnosis; epigenetics of organs injuries; miRNA and prognosis of diseases; novel approaches and proofs of principle in therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition

edited by

King-Ho Cheung

submission deadline 20 Jul 2025 | 6 articles | Viewed by 6560 | Submission Open

Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Genetic and Epigenetic Influences on Personality Traits and Athletic Performance

edited by

Kinga Huminska-Lisowska

submission deadline 20 Jul 2025 | 1 articles | Viewed by 6466 | Submission Open

Keywords: genetics; epigenetics; personality traits; athletic performance; polymorphisms; microbiome; neurotransmitters; molecular mechanisms; metabolic health; injury susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

Microplastics and Nanoplastics Ecotoxicological Effects in Seawater and Freshwater Organisms

edited by

Carlos García

submission deadline 20 Jul 2025 | 3 articles | Viewed by 6351 | Submission Open

Keywords: microplastics; exposure; aquatic organisms; sorption; degradation; bioaccumulation; biomagnification; migration; bioindicators; marine toxins

(This special issue belongs to the Section Molecular Toxicology)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases

edited by

Niels Schaft

submission deadline 20 Jul 2025 | 3 articles | Viewed by 6322 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition

edited by

Ralf Kircheis

and

Oliver Planz

submission deadline 20 Jul 2025 | 5 articles | Viewed by 6290 | Submission Open

Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies

(This special issue belongs to the Section Molecular Immunology)

Role of RNA Decay in Bacterial Gene Regulation

edited by Sue Lin-Chao and

Vladimir Kaberdin

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6262 | Submission Open

Keywords: RNA stabilizers; RNA decay; RNA turnover; small regulatory RNAs; post-transcriptional control

(This special issue belongs to the Section Molecular Microbiology)

New Advances in Medical Microbiology

edited by

Alberto Rizzo

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6130 | Submission Open

Keywords: clinical microbiology; clinical virology; SARS-CoV-2; HPV; sexually transmitted infections; respiratory viruses; emerging pathogens; opportunistic infections

(This special issue belongs to the Section Molecular Microbiology)

Role of Proteomics in Human Diseases and Infections

edited by

Mahamud Ur Rashid

and Kevin Coombs

submission deadline 20 Jul 2025 | 5 articles | Viewed by 6060 | Submission Open

Keywords: proteomics; human diseases; infections; biomarkers; therapeutic targets; disease pathogenesis; host– pathogen interactions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics and Therapeutics of Epileptic Neurodevelopment

edited by Christalena Sofocleous

submission deadline 20 Jul 2025 | 2 articles | Viewed by 6049 | Submission Open

Keywords: epileptic neurodevelopment; molecular diagnostics; next-generation sequencing; genetics; epigenetics; pathogenic/likely pathogenic variants; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Genitourinary Cancers

edited by

Sabrina Bossio

and

Anna Perri

submission deadline 20 Jul 2025 | 2 articles | Viewed by 6024 | Submission Open

Keywords: genitourinary cancer; molecular markers; oxi-inflammation; tumor microenvironmental; natural products

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology

edited by Ernesto Alejandro Aiello

submission deadline 20 Jul 2025 | 5 articles | Viewed by 5979 | Submission Open

Keywords: heart; vascular; signaling; cardiovascular disease; mechanism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition

edited by

Veronica Esposito

and

Antonella Virgilio

submission deadline 20 Jul 2025 | 4 articles | Viewed by 5957 | Submission Open

Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex

(This special issue belongs to the Section Biochemistry)

Genetic and Epigenetic Regulation of Reproduction

edited by

Dorota Juchno

and

Olga Jablonska

submission deadline 20 Jul 2025 | 4 articles | Viewed by 5909 | Submission Open

Keywords: gene expression; gene mapping; germ cells; epigenetic factors; DNA methylation; histone modification; fertility; molecular diagnostics; next generation sequencing; prenatal diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Host-Pathogen Interaction, 6th Edition

edited by

Andreas Burkovski

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5908 | Submission Open

Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Therapy of Cardiomyopathy

edited by

Maicon Landim-Vieira

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5791 | Submission Open

Keywords: cardiomyopathy; nutrition; exercise; pharmacology; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeted Treatments in Cancer: 2nd Edition

edited by

Kazuko Kaneda-Nakashima

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5687 | Submission Open

Keywords: TAT (targeting alpha therapy); nuclear medicine; cancer treatment; imaging; radioisotope (RI); surface marker; TRT (targeted radioisotope therapy)

(This special issue belongs to the Section Molecular Oncology)

New Insights into Gene Expression Regulation in the Next-Generation Sequencing (NGS) Era

edited by

Maria Samara

submission deadline 20 Jul 2025 | 5 articles | Viewed by 5425 | Submission Open

Keywords: alternative splicing; DNA methylation; histone modification; RNA sequencing; epigenome; metagenomics; single-cell sequencing; spatial sequencing; microenvironment; microbiome profile

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Insights into Aquaporins: 2nd Edition

edited by

Graça Soveral

and

Inês Vieira Da Silva

submission deadline 20 Jul 2025 | 4 articles | Viewed by 5418 | Submission Open

Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target

(This special issue belongs to the Section Molecular Biology)

Advances and Perspectives in Limbal Epithelial Stem Cells and Their Niche

edited by

Naresh Polisetti

and Ursula Schlötzer-Schrehardt

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5378 | Submission Open

Keywords: limbal epithelial stem cells; ocular surface; limbal stem cell niche; homeostasis; limbal mesenchymal stromal cells; regeneration; limbal melanocytes; extracellular matrix components

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Macromolecules Structure, Function, and Regulation: 2nd Edition

edited by

Zhiwei Yang

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5364 | Submission Open

Keywords: conformational dynamics; structural modeling; docking; molecular recognition; regulation mechanism; rational design; molecular dynamic simulation

(This special issue belongs to the Section Molecular Biophysics)

Displaying special issue 1101-1150 on page 23 of 68.

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