Role of Proteomics in Human Diseases and Infections

Dear Colleagues,

The human genome contains around 20,000 genes, which can be translated into over 80,000 proteins through alternative splicing. The maintenance and modification of cellular functions are orchestrated by numerous, complex signaling pathways, regulated through these proteins’ direct or indirect interactions. Disease or infections by a pathogen can cause the dysregulation of protein expressions, post-translational modification, or the impairment of their functional involvement in different signaling pathways. These changes in the cellular proteome are eventually reflected in organ-level dysfunction and may lead to severe illness or death.

This Special Issue aims to delve into the critical role proteomics plays in understanding and combating various human diseases and infections. Proteomics is pivotal in elucidating the mechanisms of diseases at the molecular level, offering insights into protein functions, modifications, and interactions within biological contexts. As we uncover the proteome of cells and tissues in health and disease, we gain valuable information that can lead to the identification of biomarkers, therapeutic targets, and a deeper understanding of disease pathogenesis and host–pathogen interactions.

We also want to welcome research on the innovative applications of proteomics in diagnosing, monitoring, and treating human diseases. We encourage submissions that explore the dynamic proteome in various diseases, the interactions between pathogens and host proteomes, and the potential of proteomics in developing novel diagnostic and therapeutic strategies.

Dr. Mahamud Ur Rashid
Prof. Dr. Kevin Coombs
Guest Editors

Manuscript Submission Information

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• proteomics
• human diseases
• infections
• biomarkers
• therapeutic targets
• disease pathogenesis
• host–pathogen interactions
• diagnostic tools