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Organic/Inorganic Nanocomposites on the Basis of 'Three Pillars' (Organic Compounds, Metal Nanoparticles, and Carbon Nanomaterials)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 3044

Special Issue Editor


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Guest Editor
Nikolaev Institute of Inorganic Cmemistry, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia
Interests: optical sensors; chemiresistive sensors; amperometric sensors; gas detection; phthalocyanine thin films
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Special Issue Information

Dear Colleagues,

Research on organic/inorganic nanocomposite materials is a fast growing interdisciplinary area in materials science and engineering. Materials on the basis of "three pillars"—organic compounds, metal nanoparticles and carbon nanomaterials—are of special interest due to their broad practical applications in organic electronic devices and in medicine.

A huge variety of organic molecules, from simple aromatic molecules to complexes with organic ligands to polymers, provides the opportunity for obtaining simple and complex structures with different physicochemical properties. Metal nanoparticles are known for their high surface-to-volume ratio, catalytic activity, and antibacterial properties. Carbon nanostructures belong to a large family, which includes carbon quantum dots, nano-onions, spheres, single- and multi-walled nanotubes, and nanofibers, as well as graphene, reduced-graphene, fullerenes etc. These three pillars are the building blocks for creating hybrid and composite materials with synergistic combinations of physicochemical properties. Organic/inorganic nanocomposite materials combining metal, carbon, and organic nanostructures attract attention both from the point of view of studying and modeling their structure and properties, and from the point of view of their applications in areas such as organic field-effect transistors, solar batteries, memory cells, sensors (monitoring of pollutants in water, food, and biological media), medicine (diagnostics and therapy), nanotechnology, energy, and others.

In this context, we invite authors to submit a manuscript to our upcoming Special Issue, “Organic/Inorganic Nanocomposites on the Basis of ‘Three Pillars’ (Organic Compounds, Metal Nanoparticles, and Carbon Nanomaterials)”, to be published at the end of March 2024. This Special Issue focuses on the development of modern organic/inorganic composite materials, especially multifunctional composites, on the basis of organic molecules with metal nanoparticles and/or carbon nanomaterials, and the study of their properties and application. Topics of interest include but are not limited to the following:

  • New organic/inorganic composite materials and their synthesis;
  • Modelling of the structure and properties of organic/inorganic composites;
  • Study of the synergetic effects in organic/inorganic composites;
  • Study of the physicochemical properties of organic/inorganic composites;
  • Applications of organic/inorganic composites.

Prof. Dr. Tamara Basova
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic/inorganic composites
  • hybrid materials
  • composite materials
  • organic films
  • polymers
  • aromatic molecules
  • metal nanoparticles
  • carbon nanomaterials
  • carbon nanotubes
  • graphene

Published Papers (3 papers)

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Research

23 pages, 11025 KiB  
Article
Gold Nanoparticles Downregulate IL-6 Expression/Production by Upregulating microRNA-26a-5p and Deactivating the RelA and NF-κBp50 Transcription Pathways in Activated Breast Cancer Cells
by Aisha Farhana, Abdullah Alsrhani, Ruqaih S. Alghsham, Wassila Derafa, Yusuf Saleem Khan and Zafar Rasheed
Int. J. Mol. Sci. 2024, 25(3), 1404; https://doi.org/10.3390/ijms25031404 - 24 Jan 2024
Viewed by 988
Abstract
MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences’ 3′ untranslated regions (3′UTR). Interleukin-6 (IL-6) is known to promote cancer progression and treatment resistance. In this study, we aimed to explore the therapeutic effects of gold [...] Read more.
MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences’ 3′ untranslated regions (3′UTR). Interleukin-6 (IL-6) is known to promote cancer progression and treatment resistance. In this study, we aimed to explore the therapeutic effects of gold nanoparticles (GNP) against IL-6 overexpression and the modulation of miRNA-26a-5p in breast cancer (BC) cells. GNP were synthesized using the trisodium citrate method and characterized through UV-Vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). To predict the binding of miR-26a-5p in the IL-6 mRNA’s 3′UTR, we utilized bioinformatics algorithms. Luciferase reporter clone assays and anti-miRNA-26a-5p transfection were employed to validate the binding of miR26a-5p in the IL-6 mRNA’s 3′UTR. The activity of RelA and NF-κBp50 was assessed and confirmed using Bay 11-7082. The synthesized GNP were spherical with a mean size of 28.3 nm, exhibiting high stability, and were suitable for BC cell treatment. We found that miR-26a-5p directly regulated IL-6 overexpression in MCF-7 cells activated with PMA. Treatment of MCF-7 cells with GNP resulted in the inhibition of IL-6 overexpression and secretion through the increase of miR26a-5p. Furthermore, GNP deactivated NF-κBp65/NF-κBp50 transcription activity. The newly engineered GNP demonstrated safety and showed promise as a therapeutic approach for reducing IL-6 overexpression. The GNP suppressed IL-6 overexpression and secretion by deactivating NF-κBp65/NF-κBp50 transcription activity and upregulating miR-26a-5p expression in activated BC cells. These findings suggest that GNP have potential as a therapeutic intervention for BC by targeting IL-6 expression and associated pathways. Full article
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24 pages, 8881 KiB  
Article
Vapor-Phase-Deposited Ag/Ir and Ag/Au Film Heterostructures for Implant Materials: Cytotoxic, Antibacterial and Histological Studies
by David S. Sergeevichev, Svetlana I. Dorovskikh, Evgeniia S. Vikulova, Elena V. Chepeleva, Maria B. Vasiliyeva, Tatiana P. Koretskaya, Anastasiya D. Fedorenko, Dmitriy A. Nasimov, Tatiana Y. Guselnikova, Pavel S. Popovetsky, Natalya B. Morozova and Tamara V. Basova
Int. J. Mol. Sci. 2024, 25(2), 1100; https://doi.org/10.3390/ijms25021100 - 16 Jan 2024
Viewed by 775
Abstract
Using gas-phase deposition (Physical Vapor Deposition (PVD) and Metal Organic Chemical Vapor Deposition (MOCVD)) methods, modern implant samples (Ti alloy and CFR-PEEK polymer, 30% carbon fiber) were functionalized with film heterostructures consisting of an iridium or gold sublayer, on the surface of which [...] Read more.
Using gas-phase deposition (Physical Vapor Deposition (PVD) and Metal Organic Chemical Vapor Deposition (MOCVD)) methods, modern implant samples (Ti alloy and CFR-PEEK polymer, 30% carbon fiber) were functionalized with film heterostructures consisting of an iridium or gold sublayer, on the surface of which an antibacterial component (silver) was deposited: Ag/Ir(Au)/Ti(CFR-PEEK). The biocidal effect of the heterostructures was investigated, the effect of the surface relief of the carrier and the metal sublayer on antibacterial activity was established, and the dynamics of silver dissolution was evaluated. It has been shown that the activity of Ag/Ir heterostructures was due to high Ag+ release rates, which led to rapid (2–4 h) inhibition of P. aeruginosa growth. In the case of Ag/Au type heterostructures, the inhibition of the growth of P. aeruginosa and S. aureus occurred more slowly (from 6 h), and the antibacterial activity appeared to be due to the contribution of two agents (Ag+ and Au+ ions). It was found, according to the in vitro cytotoxicity study, that heterostructures did not exhibit toxic effects (cell viability > 95–98%). An in vivo biocompatibility assessment based on the results of a morphohistological study showed that after implantation for a period of 30 days, the samples were characterized by the presence of a thin fibrous capsule without volume thickening and signs of inflammation. Full article
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19 pages, 8060 KiB  
Article
New Ethynylphenylborasilsesquioxanes—Their Reactivity and Behavior during Thermal Decomposition
by Miłosz Frydrych, Bogna Sztorch, Robert E. Przekop and Bogdan Marciniec
Int. J. Mol. Sci. 2023, 24(18), 13960; https://doi.org/10.3390/ijms241813960 - 11 Sep 2023
Cited by 1 | Viewed by 736
Abstract
In this paper, a new type of borasilsesquioxanes was synthesized through a condensation process, and its reactivity in catalytic hydrosilylation reactions with silanes, siloxanes, and silsesquioxanes was investigated. The obtained compounds were mostly obtained in >90% yield. They were fully characterized using spectroscopic [...] Read more.
In this paper, a new type of borasilsesquioxanes was synthesized through a condensation process, and its reactivity in catalytic hydrosilylation reactions with silanes, siloxanes, and silsesquioxanes was investigated. The obtained compounds were mostly obtained in >90% yield. They were fully characterized using spectroscopic (1H, 13C, 29Si NMR) and spectrometric (MALDI-TOF-MS) methods. The next stage of the research involved studying the thermogravimetric properties of the borasilsesquioxanes. By analyzing the different stages of decomposition using spectroscopic techniques (NMR, ATR-FTIR, Raman) and microscopic imaging, it was found that the structure of the borasilsesquioxanes changed during the pyrolysis process and polymer compounds were formed. Full article
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