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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Green Chemistry Biocatalysis—Advances in the Use of Sustainable Solvents for Biocatalytic Processes

edited by

Rita Craveiro

and

Alexandre Paiva

submission deadline 20 Jan 2026 | Viewed by 706 | Submission Open

Keywords: biocatalysts; enzymes; sustainability; green solvents; biotechnology; biochemical process engineering

(This special issue belongs to the Section Biochemistry)

DNA Damage and Repair: Current Research

edited by

Mahara A. Valverde Ramírez

and Emilio Rojas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 657 | Submission Open

Keywords: DNA damage; DNA repair; endogenous compounds; exogenous compounds; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cell Membrane Electroporation and Electroosmosis Mechanisms

edited by

Paulius Ruzgys

submission deadline 20 Jan 2026 | Viewed by 649 | Submission Open

Keywords: nanosecond electroporation; calcium electroporation; small-molecule electrotransfer; abscopal effect; bacterial electroporation; irreversible electroporation; electrochemotherapy; immune response; apoptosis

(This special issue belongs to the Section Biochemistry)

The Impact of High-Value Compounds from Agri-Food and Waste Sources on Cellular Metabolism

edited by

Anna Spagnoletta

Salvatore Nesci

and

Francesca Oppedisano

submission deadline 20 Jan 2026 | Viewed by 616 | Submission Open

Keywords: phytochemicals; agri-food waste; nutraceutical; cell metabolism; mitochondria; antioxidants; ROS; anti-cancer

(This special issue belongs to the Section Biochemistry)

Reaction Kinetics in Bioinorganic Systems

edited by Łukasz Orzeł and Maria Oszajca

submission deadline 20 Jan 2026 | Viewed by 610 | Submission Open

Keywords: reaction mechanisms; kinetics; biologically active metal complexes; metalloproteins; reactive oxygen; nitrogen and sulfur species; biocatalysis; inorganic chemotherapy and phototherapy

(This special issue belongs to the Section Biochemistry)

Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy

edited by

Mateusz Kciuk

and

Damian Kołat

submission deadline 20 Jan 2026 | Viewed by 582 | Submission Open

Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets

(This special issue belongs to the Section Biochemistry)

Latest Molecular Research on Muscle Atrophy

edited by

Elena Bresciani

submission deadline 20 Jan 2026 | Viewed by 547 | Submission Open

Keywords: muscle atrophy; molecular mechanisms; protein degradation; inflammation; oxidative stress; sarcopenia; cachexia; autophagy; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endocannabinoids, Cannabinoids and Psychiatry: Biological Mechanisms—3rd Edition

edited by

Aron Weller

and Nicholas V. DiPatrizio

submission deadline 20 Jan 2026 | Viewed by 536 | Submission Open

Keywords: endocannabinoids; cannabinoids; psychiatry; neural mechanisms; molecular mechanisms; epigenetics; imaging; psychopathology; stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeting Epilepsy: Molecular Mechanisms, Neuroinflammation and Emerging Therapies

edited by

Karoly Orban-Kis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 511 | Submission Open

Keywords: epilepsy; molecular targets; antiepileptic drug discovery; neuroinflammation; epileptogenesis; ion channels; pharmacoresistance; translational neuroscience

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Disorders: From Molecular Mechanisms to Nanomedicine

edited by

Aruna Sharma

submission deadline 20 Jan 2026 | Viewed by 502 | Submission Open

Keywords: stroke; brain and spinal cord trauma; Alzheimer’ s disease; Parkinson’ s disease; nanodrug formulation; stem cells; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Microglia in Neurological Diseases

edited by

Pyung-Hwan Kim

submission deadline 20 Jan 2026 | Viewed by 489 | Submission Open

Keywords: microglia; neuroinflammation; neurodegenerative diseases; molecular signaling; central nervous system (CNS)

(This special issue belongs to the Section Molecular Neurobiology)

Hormone Receptors in Cancer

edited by Rajeshwar R. Tekmal

submission deadline 20 Jan 2026 | Viewed by 462 | Submission Open

Keywords: hormone recptors; hormone-mediated therapies; agonists and antgonists of hormone ligands; coactivators; corepressors

(This special issue belongs to the Section Molecular Oncology)

Insights into How Electromagnetic Fields Affect Human Immunity and Metabolic Activity

edited by Jolanta Kaszuba-Zwoińska

submission deadline 20 Jan 2026 | Viewed by 455 | Submission Open

Keywords: electromagnetic fields; metabolism; innate and acquired immunity; cell viability; cell secretory activity; cell death types; pathogenesis of diseases

(This special issue belongs to the Section Molecular Biology)

Drug Discovery and Development for Renal Disease Treatment

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | Viewed by 442 | Submission Open

Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies

(This special issue belongs to the Section Molecular Pharmacology)

Synthesis and Application of Organic Antibacterial Agents

edited by

Barbara Dmochowska

submission deadline 20 Jan 2026 | Viewed by 439 | Submission Open

Keywords: organic antibacterial compounds; synthesis; natural organic compounds; biological activity; active compounds; biological applications

(This special issue belongs to the Section Biochemistry)

The Plant Phenotyping and Phenomics for Breeding

edited by

Jaeil Lyu

submission deadline 20 Jan 2026 | Viewed by 435 | Submission Open

Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype– phenotype association; non-invasive imag-ing; functional genomics; environmental interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Cognitive Aging: Molecular Perspectives

edited by

Igor Y. Iskusnykh

submission deadline 20 Jan 2026 | Viewed by 430 | Submission Open

Keywords: brain; neuron; aging; neurodegeneration; cognitive neuroscience; inflammation; regeneration; behavioral neuroscience; pharmacology; brain disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolomics Research of Environmental Stress in Plants

edited by

Manish Kumar Patel

and Sonika Pandey

submission deadline 20 Jan 2026 | Viewed by 428 | Submission Open

Keywords: agricultural applications of primary and secondary metabolite; ; crop improvement; integration of metabolomics with genomics and transcriptomics; medicinal plants; natural products in agriculture; plant metabolomics; plant biochemistry; primary metabolites; secondary metabolites; tools and techniques of plant metabolites in agriculture research

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Animal Reproduction and Development

edited by

Yu-Feng Wang

submission deadline 20 Jan 2026 | Viewed by 414 | Submission Open

Keywords: spermatogenesis; oogenesis; fertilization; embryogenesis; cell division; cell differentiation; stem cell; abnormal development; obesity; cancer

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases, 3rd Edition

edited by

Paramjit S. Tappia

submission deadline 20 Jan 2026 | Viewed by 389 | Submission Open

Keywords: cardiovascular diseases; metabolic diseases; cellular and molecular mechanisms

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Innovations in Organic Framework Materials: Expanding the Horizons of COFs, MOFs, and HOFs for Advanced Applications

edited by Bhausaheb Dhokale

submission deadline 20 Jan 2026 | Viewed by 388 | Submission Open

Keywords: COF; MOF; HOF; synthesis; molecular applications; porous materials; molecular engineering; membranes; theoretical studies; energy

(This special issue belongs to the Section Materials Science)

Advancements and Trends in Plant Genomics

edited by Rongbin Hu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 375 | Submission Open

Keywords: plant; genomics; next-generation sequencing; third-generation sequencing; CRISPR-Cas

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Biology and Diagnosis on Biliary and Pancreatic Cancers

edited by Francesco Vasuri and Luca Saragoni

submission deadline 20 Jan 2026 | Viewed by 368 | Submission Open

Keywords: biliary cancer; pancreatic cancer; histological diagnoses; cytological diagnoses; chromosome aneuploidy; specific genetic mutations

(This special issue belongs to the Section Molecular Oncology)

DNA and RNA Nanostructures for the Assembly of Functional Molecules

edited by

Di Liu

and

Kalevi Kairemo

submission deadline 20 Jan 2026 | Viewed by 362 | Submission Open

Keywords: DNA nanotechnology; RNA nanotechnology; biomolecular engineering; biomimetics

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Plant Cell Dynamics

edited by

Andrei Smertenko

submission deadline 20 Jan 2026 | Viewed by 358 | Submission Open

Keywords: organelles; cellular polarity; cytoskeleton; vesicle trafficking; cell wall synthesis; signalling; differentiation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Autophagy, 2nd Edition

edited by

Maria Ines Vaccaro

submission deadline 20 Jan 2026 | Viewed by 357 | Submission Open

Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insight into Bacteriophage and Their Potential Applications

edited by Wilfried Moreira

submission deadline 20 Jan 2026 | Viewed by 345 | Submission Open

Keywords: bacteriophage; phage biology; phage-host interactions; antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Advances in Sepsis: Molecular and Biochemical Perspectives

edited by

Akrivi Chrysanthopoulou

submission deadline 20 Jan 2026 | Viewed by 343 | Submission Open

Keywords: sepsis; outcome; molecular diagnosis; machine learning; biochemical biomarkers; targeted immunotherapy; personalized medicine; sepsis inflammatory endotypes

(This special issue belongs to the Section Biochemistry)

Liver Transplantation: Pathogenesis, Therapeutic Strategies and Future Challenges

edited by

Francesco Tandoi

submission deadline 20 Jan 2026 | Viewed by 332 | Submission Open

Keywords: MASLD; transplant oncology; machine perfusion; extended-criteria donors; donors after cardiac death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Molecular and Psycho-Physiological Insights on “Brain Fatigue”

edited by

Takehiko Fujino

and

Masanori Honsho

submission deadline 20 Jan 2026 | Viewed by 322 | Submission Open

Keywords: epigenetics; neurotransmitter including dopamine; mitochondria dysfunction; neuroinflammation; lipidomics including plasmalogen; proteomics including neuropeptide; neural network; cognition abilities; decline in attention; judgement capacity; depressive state

(This special issue belongs to the Section Molecular Neurobiology)

Cutting-Edge Advances in Transcriptional Therapy and Nucleic Acid-Based Therapeutics

edited by

Vincenza Barresi

submission deadline 20 Jan 2026 | Viewed by 318 | Submission Open

Keywords: antisense oligonucleotides (ASOs); siRNAs; peptide nucleic acids (PNAs); aptamers; transcriptional therapy; nanocarriers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Applications of Programmable Nanobiomaterials in Cancer Targeting and Therapy

edited by Wensheng Xie

submission deadline 20 Jan 2026 | Viewed by 318 | Submission Open

Keywords: programmable nanobiomaterials; cancer targeting; cancer combined therapy; tumor imaging; field-responsive nanomaterials

(This special issue belongs to the Section Molecular Biophysics)

New Optical, Electrical, and Thermal Materials: Recent Advances and Challenges

edited by Luyi Zou

submission deadline 20 Jan 2026 | Viewed by 315 | Submission Open

Keywords: optical materials; electrical materials; thermal materials; molecular structure; molecular composition; structural performance

(This special issue belongs to the Section Materials Science)

The Role of Extracellular Vesicles in Drug Delivery

edited by

Sara Biagiotti

and

Michele Guescini

submission deadline 20 Jan 2026 | Viewed by 293 | Submission Open

Keywords: red blood cells; red blood cell-extracellular vesicles; drug delivery systems; RNA therapies; EV engineering

(This special issue belongs to the Section Molecular Biology)

Single-Atom Catalysts for Small Molecule Transformation

edited by Aijuan Han

submission deadline 20 Jan 2026 | Viewed by 291 | Submission Open

Keywords: single-atom catalyst; small molecule transformation; rational design; applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Exploring the New Cancer Biomarkers: Progress and Prospects

edited by

Marcelo José Barbosa Silva

submission deadline 20 Jan 2026 | Viewed by 277 | Submission Open

Keywords: prevention; diagnostic; prognostic; response; liquid biopsy; image biomarkers; clinicopathological biomarkers

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Coagulation Proteins

edited by

Arijit Biswas

submission deadline 20 Jan 2026 | Viewed by 275 | Submission Open

Keywords: coagulation proteins; hemostasis; thrombosis; structural biology; Cryo-EM; inherited coagulation disorders

(This special issue belongs to the Section Molecular Biology)

Environmental and Human Adverse Effects of Micro and Nanoplastics: 2nd Edition

edited by

Elena Niccolai

submission deadline 20 Jan 2026 | Viewed by 274 | Submission Open

Keywords: micro and nanoplastics; environmental pollution; micro and nanoplastic toxicity; human health

(This special issue belongs to the Section Molecular Toxicology)

Molecular Insights into Environmental Toxicology in Cancer

edited by

Silvia Vivarelli

submission deadline 20 Jan 2026 | Viewed by 270 | Submission Open

Keywords: environmental carcinogenesis; toxic exposure; exposome; occupational cancer risk; biomarkers of exposure; new approach methodologies (NAMs)

(This special issue belongs to the Section Molecular Oncology)

Polymer Materials Related to Food Packaging

edited by

Rosie Yagmur Yegin

submission deadline 20 Jan 2026 | Viewed by 266 | Submission Open

Keywords: polymeric materials; food packaging; biodegradable polymers; active packaging; intelligent packaging; nanocomposites; sustainability; circular economy; barrier properties; life cycle assessment

(This special issue belongs to the Section Macromolecules)

Advancements in Cytopathology: Challenges and Changes

edited by Panagiota Mikou

submission deadline 20 Jan 2026 | Viewed by 264 | Submission Open

Keywords: cytopathology; cancer diagnosis; cytology; early cancer detection; exfoliative cytology

(This special issue belongs to the Section Molecular Biology)

Photosynthesis and Stress Signaling

edited by

Liangsheng Wang

submission deadline 20 Jan 2026 | Viewed by 259 | Submission Open

Keywords: photosynthesis; chloroplasts; stress; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Psoriasis and Associated Complications: Pathogenic Mechanisms, Gene Biomarkers and Treatments

edited by

Anna Michalak-Stoma

submission deadline 20 Jan 2026 | Viewed by 248 | Submission Open

Keywords: psoriasis; autoimmune disease; autoinflammatory disease; psoriatic arthritis; diabetes; hypertension; lipid disorders; obesity; cardiovascular diseases (CVDs); immunological biomarkers; genetic biomarkers; epigenetic biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurohormones in Cardiac Fibrosis and Heart Failure

edited by

Helmy M. Siragy

submission deadline 20 Jan 2026 | Viewed by 247 | Submission Open

Keywords: heart failure; neurohormones; cardiac fibrosis; angiotensin II; aldosterone; endothelin; catecholamines

(This special issue belongs to the Section Molecular Biology)

Density Functional Theory and Its Application in Atomic Collision Models

edited by

Feng Wang

submission deadline 20 Jan 2026 | Viewed by 242 | Submission Open

Keywords: density functional theory; time-dependent density functional theory; finite-temperature density functional theory; ensemble density functional theory; atom collision models; electron stopping power

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms and Therapeutic Potential of Natural Compounds

edited by

Magdalena Bartnik

and Adrianna Sławińska-Brych

submission deadline 20 Jan 2026 | Viewed by 237 | Submission Open

Keywords: natural products; biological activity; bioactive compounds; mechanistic study; mechanism of action; drug discovery; pharmacological activity; synergism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Effects of Co-Exposure of Pollutants on Animal Models

edited by

Chiara Maria Motta

submission deadline 20 Jan 2026 | Viewed by 230 | Submission Open

Keywords: environmental health; biological systems; toxic exposure; co-exposure; physiological mechanisms; behavioral responses; gene expression; epigenetic effects; molecular research

(This special issue belongs to the Section Molecular Toxicology)

Novel Insights into Mitochondrial Signaling and Homeostasis in Metabolic Diseases

edited by Ching-Yi Chen

submission deadline 20 Jan 2026 | Viewed by 224 | Submission Open

Keywords: diabetes mellitus; cardiovascular disease; fatty liver; chronic kidney disease; mitochondrial homeostasis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanism of Immune Response

edited by Marisa Mariel Fernández

submission deadline 20 Jan 2026 | Viewed by 214 | Submission Open

Keywords: training of the innate immune response; antigen recognition; cell migration; autoimmune processes; cell differentiation; tolerance; molecular responses of epithelial cells to foreign stimuli; alterations in immune checkpoints; modulation of immune responses; mechanisms of hypersensitivity

(This special issue belongs to the Section Molecular Immunology)

Nanomedicine for Diagnostic and Therapeutic Application

edited by

Nicola D'Avanzo

and Antonella Barone

submission deadline 20 Jan 2026 | Viewed by 205 | Submission Open

Keywords: polymeric nanoparticles; lipid nanoparticles; diagnostic; theranostic; targeted drug delivery; nonovesicles; prescion medicine

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 451-500 on page 10 of 65.

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