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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drosophila: A Versatile Model in Biology and Medicine—2nd Edition

edited by

Maria Grazia Giansanti

and

Roberto Piergentili

submission deadline 31 May 2025 | 2 articles | Viewed by 1348 | Submission Open

Keywords: model organism; human disease; inherited disease; cancer; neurodegeneration; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Allelic Imbalance by Genetic and Epigenetic Factors

edited by Anthoula Chatzikyriakidou

submission deadline 31 May 2025 | 1 articles | Viewed by 1293 | Submission Open

Keywords: allele-specific expression; allelic imblance; genetic variant; epialleles; variant classification; genetic heterogeneity; incomplete penetrance; variable expressivity; mendelian/non-mendelian inheritance

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cancer Drug Treatment and Cancer Cell Drug Resistance

edited by

Juan Sebastian Yakisich

submission deadline 31 May 2025 | 2 articles | Viewed by 1217 | Submission Open

Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Extraction, Isolation and Identification of Natural Chemicals

edited by Jiaozhen Zhang

submission deadline 31 May 2025 | 1 articles | Viewed by 1133 | Submission Open

Keywords: extraction; isolation; identification; natural chemicals; biological activities

(This special issue belongs to the Section Biochemistry)

Membrane Proteins: Structure, Function, and Drug Discovery

edited by

Masafumi Yohda

submission deadline 31 May 2025 | 1 articles | Viewed by 1126 | Submission Open

Keywords: ion channel; GPCR (G-protein-coupled receptor); membrane transporters; signal transduction; membrane lipids; cryo-EM (cryo-electron microscopy); membrane protein folding; membrane rafts; reconstitution

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Nanoparticles in Molecular Biology: Second Edition

edited by

Maciej Monedeiro-Milanowski

submission deadline 31 May 2025 | 1 articles | Viewed by 1115 | Submission Open

Keywords: nanoparticles; nanomedicine; biomolecules; nanoparticle– cell interactions; organic– inorganic hybrid; cytotoxic potential

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research on Sjögren’s Syndrome: From Pathogenesis to Therapy

edited by Alexandru Emil Caraba

submission deadline 31 May 2025 | 1 articles | Viewed by 1041 | Submission Open

Keywords: Sjö gren's syndrome; salivary glands; lacrimal glands; T and B cells; macrophage; dendritic cells; salivary gland epithelial cells; inflammatory mediators (cytokines; chemokines; antibodies); intracellular signaling pathways (IFN; TLR; BAFF/BAFF-R; PI3K/Akt/mTOR); atherosclerosis; lymphoma; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research on Plant Genomics and Genome Editing, 2nd Edition

edited by

Fabrizio Carbone

submission deadline 31 May 2025 | 2 articles | Viewed by 1032 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic and Epigenetic Analyses in Cancer

edited by Jing Gong

submission deadline 31 May 2025 | 2 articles | Viewed by 1032 | Submission Open

Keywords: epigenetics; genetic mutations; chromosomal instability; DNA methylation; histone modifications; non-coding rnas; multi-omics; transcriptomics; proteomics; drug resistance in cancer; cancer biomarkers; therapeutic targets in cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Variations in Human Diseases: 2nd Edition

edited by

Paweł Niemiec

submission deadline 31 May 2025 | 2 articles | Viewed by 1016 | Submission Open

Keywords: genetic polymorphism; gene– gene interaction; gene– environment interaction; monogenic disorder; mutation; phenotype; quantitative trait locus; family-based study; cohort study; association study

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in the Pathogenesis and Treatment of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 31 May 2025 | 1 articles | Viewed by 989 | Submission Open

Keywords: heart failure; biomarkers; pathways of heart failure; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress on the Mechanism and Treatment of Cardiomyopathy: Second Edition

edited by

Michael T. Chin

submission deadline 31 May 2025 | 1 articles | Viewed by 946 | Submission Open

Keywords: cardiomyopathy; heart failure; cardiac hypertrophy; dilated cardiomyopathy; restrictive cardiomyopathy; hypertrophic cardiomyopathy; ischemic cardiomyopathy; viral cardiomyopathy; inherited cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Pathogenesis and Treatment of Pregnancy Complications

edited by

Melissa Wilson

submission deadline 31 May 2025 | 1 articles | Viewed by 864 | Submission Open

Keywords: hypertensive disorders of pregnancy; preeclampsia; molecular biology; biomarker; prevention; therapeutics; placenta

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insights in Cardiac Research: Mechanisms, Therapies, and Emerging Technologies

edited by

Francesco Lodola

submission deadline 31 May 2025 | 1 articles | Viewed by 792 | Submission Open

Keywords: cardiac cellular physiology; gene therapy; arrhythmias; optical stimulation; precision therapy; cardiomyopathies; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 31 May 2025 | 1 articles | Viewed by 788 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects

edited by

Angelo Montana

and

Fabrizio Lo Faro

submission deadline 31 May 2025 | Viewed by 774 | Submission Open

Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Pharmacology)

Advances of Organic Synthesis in Drug Discovery

edited by

Laura Gabriela Sârbu

submission deadline 31 May 2025 | 2 articles | Viewed by 723 | Submission Open

Keywords: organic synthesis; drug design; heterocyclic chemistry; functionalization

(This special issue belongs to the Section Molecular Pharmacology)

Precision Medicine Approaches to Antifibrotic Therapy

edited by Karim Daliri

submission deadline 31 May 2025 | 1 articles | Viewed by 677 | Submission Open

Keywords: fibrotic diseases; antifibrotic therapy; antifibrotic drug; multi-omics data; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 31 May 2025 | 1 articles | Viewed by 628 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Fruit Tree Physiology, Breeding and Genetic Research

edited by Jiangping Mao

submission deadline 31 May 2025 | 1 articles | Viewed by 533 | Submission Open

Keywords: fruit tree; genetic breeding; fruit tree physiology; gene functional identification

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Organic Chemistry: Molecule Synthesis and Reactions (2nd Edition)

edited by

José Justicia

and

Rachid Chahboun

submission deadline 31 May 2025 | 1 articles | Viewed by 514 | Submission Open

Keywords: bioactive natural products; organocatalysis; photoredox reactions; free-radical reactions; organometallic reactions; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Insights into Antimicrobial Activity

edited by

Liliana Mititelu Tartau

submission deadline 31 May 2025 | 1 articles | Viewed by 506 | Submission Open

Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic

(This special issue belongs to the Section Molecular Microbiology)

Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue

edited by

Ahmed Bettaieb

submission deadline 31 May 2025 | Viewed by 502 | Submission Open

Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting

(This special issue belongs to the Section Molecular Biology)

New Insights into Nutritional Regulation on Gut Microbiota

edited by

Yaotsung Yeh

submission deadline 31 May 2025 | Viewed by 494 | Submission Open

Keywords: gut microbiota; dysbiosis; nutritional regulation; foods; diets

(This special issue belongs to the Section Molecular Microbiology)

Recent Advances in Soybean Molecular Breeding

edited by Dong Cao

submission deadline 31 May 2025 | 1 articles | Viewed by 492 | Submission Open

Keywords: soybean; plant architecture; adaptation; yield improvement; molecular breeding; nutritional quality traits; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

New Molecular Insights into Ischemia/Reperfusion: 2nd Edition

edited by

Moo-Ho Won

submission deadline 31 May 2025 | 1 articles | Viewed by 458 | Submission Open

Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress on Oocyte Development

edited by

Ken-ichi Sato

submission deadline 31 May 2025 | 1 articles | Viewed by 369 | Submission Open

Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility

(This special issue belongs to the Section Molecular Biology)

Molecular Regulation of Animal Fat and Muscle Development

edited by Taiyong Yu

submission deadline 31 May 2025 | 1 articles | Viewed by 361 | Submission Open

Keywords: animal fat; muscle development; adipogenesis; PPARγ ; C/EBPs; food additives; metabolic pathways; meat quality; preadipocytes; MyoD

(This special issue belongs to the Section Molecular Biology)

Supramolecular Chiral Self-Assembly and Applications

edited by

Victor Borovkov

Alessandro D'Urso

and

Manuela Stefanelli

submission deadline 31 May 2025 | Viewed by 315 | Submission Open

Keywords: (supra)molecular chirality; chiral self-assembly; enantioselective catalysis

(This special issue belongs to the Section Macromolecules)

Innovative Approaches in Organic Synthesis and Functional Materials: From Design to Biological Impact

edited by

Antonio Rescifina

and

Chiara Zagni

submission deadline 31 May 2025 | Viewed by 279 | Submission Open

Keywords: organic synthesis; bioactive molecules; functional materials; molecular informatics; biological activity; molecular docking; computational chemistry; drug design; medicinal chemistry; quantitative structure– activity relationships (QSARs); environmental applications; sustainable chemistry; natural products

(This special issue belongs to the Section Molecular Informatics)

Quantum Chemical Approaches for Investigating Reaction Mechanisms in Organic Chemistry

edited by

Robert O'Reilly

submission deadline 31 May 2025 | Viewed by 272 | Submission Open

Keywords: organic chemistry; biochemistry; density functional theory; coupled cluster theory; free radicals; reaction mechanisms; transition states

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecularly Targeted Therapy and Regulation of Signaling Pathway in Oral Squamous Cell Carcinoma

edited by

Lucrezia Togni

submission deadline 31 May 2025 | 1 articles | Viewed by 259 | Submission Open

Keywords: head and neck cancers; oral squamous cell carcinoma; targeted therapies; omics sciences; signaling pathway; mutations; prognosis; diagnostic markers

(This special issue belongs to the Section Molecular Oncology)

Endothelial-to-Mesenchymal Transition: A Key Driver of Tumor Progression and Therapeutic Resistance

edited by

Gabriella Doronzo

submission deadline 31 May 2025 | Viewed by 236 | Submission Open

Keywords: Endothelial-to-Mesenchymal Transition; wound healing and fibrosis; tumor progression; abnormal blood vessel formation; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Mechanotransduction and Tissue Regeneration in Skeletal Muscle

edited by

Mahtab Nourbakhsh

submission deadline 31 May 2025 | Viewed by 224 | Submission Open

Keywords: skeletal muscle tissue regeneration; mechanotransduction; skeletal muscle spindles; tissue-resident macrophages

(This special issue belongs to the Section Molecular Biology)

Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases

edited by

Ming-Chang Chiang

submission deadline 31 May 2025 | Viewed by 219 | Submission Open

Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Research in Nanophotonics and Biophotonics

edited by

Prabhakar Pradhan

submission deadline 31 May 2025 | Viewed by 201 | Submission Open

Keywords: biophotonics; spectroscopy; light scattering; Raman/FTIR; cancer; Alzheimer's and Parkinson’ s diseases; nanophotonics; plasmonics; nano-biophotonics

(This special issue belongs to the Section Molecular Nanoscience)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 31 May 2025 | Viewed by 190 | Submission Open

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

Platelets at the Intersection of Atherosclerosis Processes

edited by

Maria Greabu

submission deadline 31 May 2025 | Viewed by 187 | Submission Open

Keywords: platelets; inflammation; atherosclerosis; endothelial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 31 May 2025 | Viewed by 187 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insight into Bacteriophage and Their Potential Applications

edited by Wilfried Moreira

submission deadline 31 May 2025 | Viewed by 187 | Submission Open

Keywords: bacteriophage; phage biology; phage-host interactions; antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

DNA Methylation in Cancer: Progress and Challenges

edited by

Michael Eccles

submission deadline 31 May 2025 | Viewed by 185 | Submission Open

Keywords: DNA methylation; cancer; hypomethylation; hypermethylation; epigenetics; tumor onset; tumor progression; technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Innovations in Neuropharmacology for Neurodegenerative Diseases

edited by Andrea Fagiolini

submission deadline 31 May 2025 | Viewed by 182 | Submission Open

Keywords: neurodegenerative diseases; neuropharmacology; alzheimer's disease; parkinson's disease; gene therapy; drug delivery systems; molecular mechanisms; biomarkers in neurodegeneration; neuroinflammation; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Mechanistic and Data-Driven Modelling Approaches for Regulatory Networks and Diseases

edited by

Tianhai Tian

submission deadline 31 May 2025 | Viewed by 181 | Submission Open

Keywords: mathematical modelling; data-driven approach; mechanistic and data dual-driven approach; hybrid modelling; machine learning; modelling of regulatory network; inference of molecular regulation; cancer; infection disease; disease intervention

(This special issue belongs to the Section Molecular Informatics)

Regulatory Mechanisms Underlying Tumorigenesis

edited by

Kazuhiko Kuwahara

submission deadline 31 May 2025 | Viewed by 172 | Submission Open

Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models

(This special issue belongs to the Section Molecular Oncology)

Apoptosis and Autophagy in Cancer Research

edited by

Ioana Berindan-Neagoe

and

Radu Pirlog

submission deadline 31 May 2025 | Viewed by 171 | Submission Open

Keywords: apoptosis; autophagy; cancer biology; coding and noncoding genomes; cell homeostasis; therapeutic strategies; cell death and survival

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Non-Conventional and Complementary Treatments for Inflammatory Bowel Disease

edited by Roberta Ottria and

Giovanni Maconi

submission deadline 31 May 2025 | Viewed by 165 | Submission Open

Keywords: inflammatory bowel disease; leaky gut; molecular mechanisms; inflammatory pathways; small molecules in inflammatory bowel disease; non-conventional treatment; complementary medicine; inflammatory cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antiviral Mechanisms of Natural/Synthetic Compounds

edited by Cybele Carina García

submission deadline 31 May 2025 | Viewed by 162 | Submission Open

Keywords: antiviral mechanisms; natural compound; synthetic compound; druggable viral/host target; emerging virus; host– virus interaction; innate antiviral response; cell-intrinsic restriction factor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovations in Photodynamic Therapy: New Horizons in Breast Cancer Care

edited by Sandeep Surendra Panikar

submission deadline 31 May 2025 | Viewed by 162 | Submission Open

Keywords: noninvasive therapy; tumor targeting; breast cancer therapy; oncology; photosensitizers; theranostics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Recent Applications of Programmable Nanobiomaterials in Cancer Targeting and Therapy

edited by Wensheng Xie

submission deadline 31 May 2025 | Viewed by 160 | Submission Open

Keywords: programmable nanobiomaterials; cancer targeting; cancer combined therapy; tumor imaging; field-responsive nanomaterials

(This special issue belongs to the Section Molecular Biophysics)

Molecular Research on Autophagy, 2nd Edition

edited by

Maria Ines Vaccaro

submission deadline 31 May 2025 | Viewed by 154 | Submission Open

Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 451-500 on page 10 of 67.

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