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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Therapy of Systemic Lupus Erythematosus
edited by Dionysis Nikolopoulos
submission deadline 20 Jul 2025 | Viewed by 334 | Submission Open
Keywords: systemic lupus erythematosus; treatment; drugs; tailored strategies; precision medicine; biologics; cell therapy; randomized clinical trials
(This special issue belongs to the Section Molecular Pharmacology)
Enhanced Anticancer Properties of Natural Products
edited by and
submission deadline 20 Jul 2025 | Viewed by 320 | Submission Open
Keywords: natural products; anticancer properties; chemotherapeutc agent; combination treatment; enhanced anticancer mechanism; signal transduction mediators; inhibitor effect; drug resistance; chemotherapy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Computational Genomics and Bioinformatics in Microbiology submission deadline 20 Jul 2025 | Viewed by 319 | Submission Open
Keywords: computational microbial genomics; comparative genomics; structural genomics; functional genomics; genomic data bioinformatics
(This special issue belongs to the Section Molecular Informatics)
Exploring Cancer Molecular Mechanisms with AI
edited by Juan Jose Lozano and Julia Sidorova
submission deadline 20 Jul 2025 | Viewed by 317 | Submission Open
Keywords: cancer; biomarker; deep learning; molecular signature; omics data; pharmacogenomics; artificial intelligence; bioinformatics
(This special issue belongs to the Section Molecular Informatics)
Acute Kidney Injury: From Molecular Pathology to Therapies submission deadline 20 Jul 2025 | Viewed by 316 | Submission Open
Keywords: acute kidney injury; acute kidney disease; biomarkers; phenotypes; pathogenesis; risk identification; prognostic impact; therapeutic approach
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights into How Electromagnetic Fields Affect Human Immunity and Metabolic Activity
edited by Jolanta Kaszuba-Zwoińska
submission deadline 20 Jul 2025 | Viewed by 311 | Submission Open
Keywords: electromagnetic fields; metabolism; innate and acquired immunity; cell viability; cell secretory activity; cell death types; pathogenesis of diseases
(This special issue belongs to the Section Molecular Biology)
Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies submission deadline 20 Jul 2025 | Viewed by 310 | Submission Open
Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions
(This special issue belongs to the Section Molecular Immunology)
Stem Cell Therapy for Neurological Disorders
edited by Gabriele Bonaventura
submission deadline 20 Jul 2025 | Viewed by 310 | Submission Open
Keywords: neurodegenerative disease; cell therapy; stem cells; induced pluripotent stem cells; disease modeling; drug target validation
(This special issue belongs to the Section Molecular Neurobiology)
Dietary Polyphenols for Improving Gut Health
edited by Andreia Gomes
submission deadline 20 Jul 2025 | Viewed by 300 | Submission Open
Keywords: microbiota diversity; gut health; polyphenols; polyphenol bioavailability; immune function; inflammation; therapeutic potential of polyphenols; host health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Diagnosis and Treatment of Migraine
edited by
submission deadline 20 Jul 2025 | Viewed by 295 | Submission Open
Keywords: migraine; pathophysiology; diagnostics; therapy; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Progress in Fighting Inflammation to Reduce Life-Threatening Organ Dysfunction
edited by
submission deadline 20 Jul 2025 | Viewed by 292 | Submission Open
Keywords: inflammasomopathy; NLRP3; nod-like receptor protein 3 inflammasome; anti-inflammatory; organ dysfunction; organ injury; organ failure
(This special issue belongs to the Section Molecular Biology)
Monoamine Signalling Pathways as a Target for Pathomechanism of Mental Disorders and Pharmacotherapy submission deadline 20 Jul 2025 | Viewed by 287 | Submission Open
Keywords: monoaminergic system; psychiatric disorders; neurotransmission regulation; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Neurobiology)
Roles of Neutrophils in Autoimmune Diseases and Cancers
edited by
submission deadline 20 Jul 2025 | Viewed by 284 | Submission Open
Keywords: neutrophils; neutrophil extracellular traps (NETs); autoimmunity; autoimmune disease(s); cancer; oncology
(This special issue belongs to the Section Molecular Immunology)
Advances in Regenerative Medicine, Organ Bioengineering and Transplantation
edited by
submission deadline 20 Jul 2025 | Viewed by 281 | Submission Open
Keywords: regenerative medicine; organ bioengineering; transplantation; allografting; stem cells; drug discovery; immunosuppression; xenotransplantation; organogenesis; biomaterials
(This special issue belongs to the Section Molecular Immunology)
The Role of Immunocytes in Cancer and New Insights into Immunotherapy
edited by Ida Franiak-Pietryga
submission deadline 20 Jul 2025 | Viewed by 271 | Submission Open
Keywords: T cells; B cells; NK cells; adoptive cell therapy; cancer; immunotherapy; checkpoint inhibitors
(This special issue belongs to the Section Molecular Immunology)
Advances in Plant Protein and Enzyme Inhibitors
edited by Yan Zhang
submission deadline 20 Jul 2025 | Viewed by 262 | Submission Open
Keywords: plant proteins; active substances; bioactive compounds; enzyme inhibitors
(This special issue belongs to the Section Molecular Plant Sciences)
Squamous Cell Carcinoma: From Molecular Mechanisms to Therapeutics
edited by
submission deadline 20 Jul 2025 | Viewed by 256 | Submission Open
Keywords: squamous cell carcinoma; immunotherapy; melanoma; non-melanoma
(This special issue belongs to the Section Molecular Oncology)
Drug Delivery Systems and Treatment of Human Diseases: Prospects and Challenges
edited by
submission deadline 20 Jul 2025 | Viewed by 245 | Submission Open
Keywords: nanodrug delivery; blood– brain barrier; antibodies therapy; molecular mechanism; neuroprotection
(This special issue belongs to the Section Molecular Pharmacology)
Pathogenic Mechanisms of Candida auris submission deadline 20 Jul 2025 | Viewed by 236 | Submission Open
Keywords: C. auris; antifungal resistance; immune evasion
(This special issue belongs to the Section Molecular Microbiology)
Innovative Molecular Diagnostic and Therapeutic Strategies for Biofilm-Associated Periprosthetic Joint Infections submission deadline 20 Jul 2025 | Viewed by 224 | Submission Open
Keywords: periprosthetic joint infections; biofilm; antimicrobial resistance; diagnosis; therapy; nanotechnology; antibody; ap-tamer; prosthetic materials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroimmune Regulation of Acute and Chronic Pain
edited by Karen M. Wagner
submission deadline 20 Jul 2025 | Viewed by 209 | Submission Open
Keywords: acute pain; chronic pain; central sensitization; neuroinflammation; neuroimmunity; neurovascular coupling; cytokines; chemokines; catacholamines; stress
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Biomarker Discovery for Rare Diseases
edited by
submission deadline 20 Jul 2025 | Viewed by 188 | Submission Open
Keywords: biomarker; rare diseases; pathological processes; cystic fibrosis; Duchenne muscular dystrophy; Ehlers-Danlos syndrome; haemophilia; sickle cell disease; primary biliary cholangitis; fabry disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pediatric Gastrointestinal and Biliary Diseases: From Molecular Basis to Therapy
edited by
submission deadline 20 Jul 2025 | Viewed by 176 | Submission Open
Keywords: pediatrics; gastroenterology; biliary; therapy; genetics; biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies of Gastrointestinal Cancer submission deadline 20 Jul 2025 | Viewed by 153 | Submission Open
Keywords: tumor microenvironment; therapy resistance; genetic mutations; oncogenes; molecular diagnostics
(This special issue belongs to the Section Molecular Oncology)
Multiple Sclerosis: From Molecular Mechanisms to Pathophysiology
edited by
submission deadline 20 Jul 2025 | Viewed by 136 | Submission Open
Keywords: multiple sclerosis; pathogenesis; blood– brain barrier; cellular pathways; neurodegeneration; biomarkers; gene– environment interaction; astrocytes; glia
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Studies of Bone Biology and Bone Tissue: 2nd Edition
edited by
submission deadline 20 Jul 2025 | Viewed by 131 | Submission Open
Keywords: bone; stem cells; immunomodulation; biomaterials; bone regeneration; bone repair; bone diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomaterials and Antibacterial Materials for Medical Applications
edited by
submission deadline 20 Jul 2025 | Viewed by 128 | Submission Open
Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings
(This special issue belongs to the Section Materials Science)
Motor Neuron Diseases: From Molecular Pathology to Novel Therapeutic Approaches
edited by
submission deadline 20 Jul 2025 | Viewed by 103 | Submission Open
Keywords: amyotrophic lateral sclerosis; motor neuron disease; genomic; proteomic; neuroinflammation; oxidative stress; calpain-2; mRNA; T-reg; SOD1
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Issues in Optic Neuropathy submission deadline 20 Jul 2025 | Viewed by 94 | Submission Open
Keywords: optic neuropathy; neuroprotection; glaucoma induced neuropathy; molecular pathways; novel therapeutics strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardiovascular Diseases at the Molecular Level: Innovations in Research and Therapy
edited by Stefan Cristian Vesa
submission deadline 20 Jul 2025 | Viewed by 63 | Submission Open
Keywords: cardiovascular disease; molecular mechanisms; novel therapy; gene therapy; personalized medicine epigenetics; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Unveiling Mental Disorders: Molecular Mechanisms and Innovative Therapies
edited by Blerida Banushi
submission deadline 25 Jul 2025 | 3 articles | Viewed by 11915 | Submission Open
Keywords: molecular psychiatry; epigenetics; neurobiology; gene– environment interactions; neuroplasticity; psychopharmacology; neuromodulation; personalized medicine; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Male Genitourinary Tumors: Molecular Mechanisms and Potential Therapeutic Targets submission deadline 25 Jul 2025 | 5 articles | Viewed by 8871 | Submission Open
Keywords: prostate cancer; bladder cancer; biomarkers; molecular mechanisms; therapeutic targets; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances and Emerging Trends in Marine Natural Products
edited by Rafael Félix and
submission deadline 25 Jul 2025 | 3 articles | Viewed by 1826 | Submission Open
Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies
(This special issue belongs to the Section Molecular Pharmacology)
Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy
edited by Masahito Nakazaki
submission deadline 25 Jul 2025 | 1 articles | Viewed by 1176 | Submission Open
Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease
(This special issue belongs to the Section Biochemistry)
Molecular and Immune Mechanisms in Pathogenic Mycobacteria Infections
edited by Fabiana Bigi and Federico Carlos Blanco
submission deadline 25 Jul 2025 | Viewed by 350 | Submission Open
Keywords: Mycobacterium tuberculosis; virulence; pathogens  
(This special issue belongs to the Section Molecular Microbiology)
Design, Synthesis and Application of Drugs
edited by
submission deadline 25 Jul 2025 | Viewed by 348 | Submission Open
Keywords: drug design; drug synthesis; pharmaceutical applications; medicinal chemistry; pharmacology; drug development; molecular modeling; therapeutic agents; innovative therapies
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Basic Research of Autoimmune Diseases
edited by
submission deadline 25 Jul 2025 | Viewed by 149 | Submission Open
Keywords: autoimmune diseases; immunogenetics; T cells; B cells; cytokines; therapeutic targets; biomarkers; environmental triggers; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hearing Loss: Recent Progress in Molecular Genomics
edited by
submission deadline 28 Jul 2025 | 2 articles | Viewed by 1145 | Submission Open
Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Skin Diseases: Molecular Prediction, Diagnosis, Pathogenesis and Treatment
edited by
submission deadline 28 Jul 2025 | Viewed by 142 | Submission Open
Keywords: molecular pathogenesis; pigmentation disorders; vitiligo; hair follicle biology; alopecia; androgenetic alopecia; acne; rosacea; Hidradenitis suppurativa; skin inflammation; genetic epidemiology; environmental triggers; translational dermatology; therapeutic innovation; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in DNA Nanotechnology
edited by Zhaoqi Yang
submission deadline 29 Jul 2025 | Viewed by 166 | Submission Open
Keywords: DNA nanotechnology; DNA-based drug delivery; DNA cages and DNA polyhedra; DNA origami; DNA-based electronic circuits; DNA-based sensors; DNA-based catalysis; DNA-based data storage
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Advances in Gestational Diabetes Mellitus
edited by Natasha Singh
submission deadline 30 Jul 2025 | 8 articles | Viewed by 14352 | Submission Open
Keywords: metabolome; placental insulin signaling; DNA methylation; mitochondrial oxidation; MTOR; amino acids lipidomics; proteomics; gluconeogenesis; GDM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Uterine Biology and Pathophysiology, 2nd Edition
edited by
submission deadline 30 Jul 2025 | 7 articles | Viewed by 13850 | Submission Open
Keywords: human reproduction; fertility; endometrial and myometrial functionality; estrogen and progesteron receptors; sex hormones; endometrial hyperplasia; endometrial cancer and uterine sarcoma; embryo implantation; pregnancy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
RNA Biology: Unraveling the Complex Interplay Between Proteins and RNAs in Gene Expression and Regulation
edited by
submission deadline 30 Jul 2025 | 7 articles | Viewed by 12020 | Submission Open
Keywords: RNA biology; protein– RNA interplay; gene expression; post-transcriptional modifications; non-coding RNAs
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Role of Inflammation in the Etiology of Precancerous Lesions, Carcinogenesis and Cancer Treatment
edited by , Leszek Kalinowski and
submission deadline 30 Jul 2025 | 5 articles | Viewed by 11251 | Submission Open
Keywords: inflammation cascade in cancer initiation; progression and metastasis; inflammasome proteins; glycation; NOS isoforms; nitric oxide; oxidative and nitroxidative stress; DAMP; TLR; ferroptosis and necrosis in cancer etiology; COVID-19 infection; cancer and neurodegenerative isorders; inflammatory cells and cacer; primary and secondary inflammation cascade cytokines (IL-1; TNFα ; IL-18; IL-8; IL-6); chemokines; and growth factors in cancer; noncoding RNA and other epigenetic mechnisms in cancer; oxidative/nitroxidative-dependent cell signaling; breast; prostate; urogenital; renal; thyroiccolon and esophago-gastric cancers; melanomas; skin diseases associated with cancer; oncogenes; supressor genes; apoptosis; gene dysfunction and cancer; metabolomic; microbiotic; proteomic and genomic changes in cancer; biological drugs in inflammatory diseases and cancer treatment; effects of immunonutrition and microbiotic modulators on the inflammatory infiltration of the tumor microenvironment; neurodegenerative changes in cancer and after cancer treatmet; the regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in carcinogenesis and chronic inflammatory diseases
(This special issue belongs to the Section Molecular Immunology)
Innovative Molecular Strategies in Biomedicine
edited by
submission deadline 30 Jul 2025 | 4 articles | Viewed by 9471 | Submission Open
Keywords: bioprinting; organ-on-chip; venom-derived therapeutics; 3D in vitro models; skeletal muscle models; toxic peptides; peptide expression; nanoparticles in medicine; protein and peptide drug delivery; peptide-based biomaterials; self-assembled hydrogels; molecular therapeutics; nanotechnology in drug delivery; regenerative medicine; tissue engineering
(This special issue belongs to the Section Materials Science)
New Advances in Proteomics in Disease
edited by
submission deadline 30 Jul 2025 | 5 articles | Viewed by 9425 | Submission Open
Keywords: proteomics; protein; profile; molecular mechanism; biomarker; therapeutical agent
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hearing Loss: Molecular Biological Insights
edited by María Beatriz Durán-Alonso
submission deadline 30 Jul 2025 | 6 articles | Viewed by 9229 | Submission Open
Keywords: genetics; microRNA; epigenetics; CRISPR; multi-omics; presbycusis; ototoxicity; development  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stem Cells and Selected Papers Associated with 2023 STEMNET MEETING and Related Researchers
edited by and Ivana Ferrero
submission deadline 30 Jul 2025 | 4 articles | Viewed by 7307 | Submission Open
Keywords: mesenchymal stromal cell; advanced cell therapy; translational medicine; stem cell in veterinary; organoid; secretome
(This special issue belongs to the Section Biochemistry)
Advances in Plant Physiology, Biochemistry, and Biotechnology for Natural Product Synthesis
edited by
submission deadline 30 Jul 2025 | 5 articles | Viewed by 7075 | Submission Open
Keywords: medicinal plants; natural products; phytomedicine
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Product-Based Strategy for Skin Inflammatory Disorders and Regeneration
edited by
submission deadline 30 Jul 2025 | 5 articles | Viewed by 7070 | Submission Open
Keywords: inflammatory skin disorders; skin wound healing and regeneration; skin aging; bioactive natural compound; derivative and conjugate; plant extract; beneficial effect and application; molecular mechanism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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