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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Application and Molecular Mechanisms of Microwaves for Materials Processing
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 823 | Submission Open
Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering
(This special issue belongs to the Section Materials Science)
Multidrug Resistance in Cancer: Molecular Mechanisms and Therapeutic Challenges submission deadline 20 Apr 2026 | 1 articles | Viewed by 813 | Submission Open
Keywords: cancer therapy; MultiDrug Resistance (MDR); Pgp; efflux pumps; tumor microenvironment; anticancer drug target; combination therapy; novel anticancer agents
(This special issue belongs to the Section Molecular Biology)
Advanced Plant Molecular Responses to Abiotic Stresses: 2nd Edition
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 812 | Submission Open
Keywords: abiotic stress responses (heat; drought; salinity; nutrient deficiency; oxygen quality; flooding; light; etc.); genetically modified plants; CRISPR/Cas-mediated stress overcome; microplastic/nanoparticle stresses; bioinformatic studies; miRNAs and other noncoding RNAs involved in abiotic stresses in plants; secondary metabolite synthesis
(This special issue belongs to the Section Molecular Plant Sciences)
Antimicrobial Agents: Natural Products or Synthetic Compounds 2nd Edition
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 788 | Submission Open
Keywords: multidrug resistance; natural antimicrobial agents; synthetic antimicrobial compounds; combination therapy; severe infectious diseases
(This special issue belongs to the Section Molecular Microbiology)
Immune Cell Therapy and Genome Engineering submission deadline 20 Apr 2026 | 1 articles | Viewed by 767 | Submission Open
Keywords: immune cell therapies; regenerative therapy; gene editing technologies; epigenetic modulation; precision medicine; personalized therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Mechanisms of Neurodegeneration and Neuroinflammation
edited by Marika Lanza and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 758 | Submission Open
Keywords: neuroinflammation; neurodegeneration; mitochondrial dysfunction; oxidative stress; metabolomics; therapeutic strategies
(This special issue belongs to the Section Molecular Biology)
Molecular Insight into Catalysis of Nanomaterials
edited by Dandan Liu
submission deadline 20 Apr 2026 | 1 articles | Viewed by 686 | Submission Open
Keywords: nanomaterial catalyst; thermal catalysis; photocatalysis; electrocatalysis; DFT calculation
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms in Cardiovascular Disease Progression
edited by Ying-Hsi Lin
submission deadline 20 Apr 2026 | 1 articles | Viewed by 674 | Submission Open
Keywords: cardiovascular disease progression; molecular mechanisms; inflammation; signal transduction; transcriptional and epigenetic regulation; mitochondrial dysfunction; sarcomeric remodeling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Roles of Non-Coding RNAs in Cancer
edited by Amit K. Mitra
submission deadline 20 Apr 2026 | 1 articles | Viewed by 579 | Submission Open
Keywords: lncRNA; miRNA; cancer; genomics; targeted therapy; biomarkers; drug resistance
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms of Hypertension
edited by Pedro A. José
submission deadline 20 Apr 2026 | Viewed by 568 | Submission Open
Keywords: salt sensitivity; inverse salt sensitivity; epigenetics; genetics; organ-to-organ communication
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Assisted Reproductive Technologies
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 547 | Submission Open
Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology; morpho kinetics; in vitro gametogenesis; in vitro oocyte maturation; reproductive tissue cryopreservation; artificial intelligence (AI)
(This special issue belongs to the Section Molecular Biology)
Major Histocompatibility Complex Antigens in Disease
edited by Jerzy K. Kulski and Charles E. Larsen
submission deadline 20 Apr 2026 | Viewed by 534 | Submission Open
Keywords: major histocompatibility complex; immune response; human leukocyte antigen (HLA); immune function; disease susceptibility; pathogen resistance; antigenic transposable elements; cancer
(This special issue belongs to the Section Molecular Immunology)
Functional Food: Bridging the Gap Between Nutrition and Health
edited by Agata Kryczyk-Poprawa and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 532 | Submission Open
Keywords: functional foods; bioactive compounds; molecular targets; personalized nutrition strategies; chronic disease prevention; healthy aging; nutrient interactions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Evolutionary Genomics in Plants: From Single Gene to Genome
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 531 | Submission Open
Keywords: evolutionary genomics; plant adaptation; genome evolution; crop improvement; bioinformatics; polyploidy
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advancements in Studying Biomacromolecule–Ligand Interactions
edited by
submission deadline 20 Apr 2026 | Viewed by 525 | Submission Open
Keywords: biomacromolecule– ligand interaction; X-ray crystallography; nuclear magnetic resonance (NMR) spectroscopy; surface plasmon resonance (SPR); isothermal titration calorimetry (ITC); fluorescence spectroscopy (FS); mass spectrometry (MS); drug discovery
(This special issue belongs to the Section Macromolecules)
Emerging Plastic-Related Toxicity: From Environmental Exposure to Human Health submission deadline 20 Apr 2026 | 1 articles | Viewed by 525 | Submission Open
Keywords: (bio)plastic- and (bio)polymer-related toxicity; microplastic and nanoplastic accumulation/degradation in mammals; cell cultures; human health; in vivo models; epigenetics effects; endocrine disruptor properties of bioplastics; plastics and inflammation; plastics in neurodegeneration and neuroinflammation; reproduction; cell metabolism; immunomodulation
(This special issue belongs to the Section Molecular Toxicology)
Natural Compounds for Skeletal Muscle Health and Regeneration
edited by
submission deadline 20 Apr 2026 | Viewed by 520 | Submission Open
Keywords: skeletal muscle; natural compounds; molecular mechanism; muscle regeneration; computational analysis; experimental analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration
edited by Hyun Jin Shin
submission deadline 20 Apr 2026 | Viewed by 508 | Submission Open
Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring the Impact of the Biological Clock on Health and Disease
edited by
submission deadline 20 Apr 2026 | Viewed by 495 | Submission Open
Keywords: circadian rhythm; inflammation; oxidative stress; energy balance; metabolic syndrome; ageing; cancer; diabetes; obesity; entrainment; synchrony; melatonin
(This special issue belongs to the Section Molecular Biology)
Mitochondrial Energy Metabolism in Cells and Tissues
edited by
submission deadline 20 Apr 2026 | Viewed by 453 | Submission Open
Keywords: mitochondria; mitophagy; mitochondrial biogenesis; mitochondrial dynamics; fusion; fission; energy metabolism
(This special issue belongs to the Section Molecular Biology)
Molecular Biology and Chemistry of Mycotoxins and Phytotoxins, 3rd Edition
edited by
submission deadline 20 Apr 2026 | Viewed by 445 | Submission Open
Keywords: aflatoxins; trichothecenes; fumonisins; ochratoxins; host-specific toxins; Alternaria toxins; emerging mycotoxins; biosynthesis; gene cluster; transcriptional regulation; toxicity; modification; ecological role
(This special issue belongs to the Section Molecular Toxicology)
Membrane Channels in Intercellular Communication submission deadline 20 Apr 2026 | Viewed by 439 | Submission Open
Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell– cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH
(This special issue belongs to the Section Biochemistry)
Nose-to-Brain Drug Delivery: Opportunities and Challenges
edited by
submission deadline 20 Apr 2026 | Viewed by 435 | Submission Open
Keywords: nose-to-brain drug delivery; brain drug delivery system; CNS diseases; intranasal administration; nasal formulation
(This special issue belongs to the Section Molecular Pharmacology)
MicroRNAs in Physiology and Pathophysiology
edited by Małgorzata Guz
submission deadline 20 Apr 2026 | 1 articles | Viewed by 411 | Submission Open
Keywords: miRNA; cell physiology; metabolism; cancer; biomarkers; disease; molecular mechanisms; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research Progress of Orthopedic Materials
edited by Robert Karpiński
submission deadline 20 Apr 2026 | Viewed by 408 | Submission Open
Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings
(This special issue belongs to the Section Materials Science)
Psychobiotics as Next-Generation Probiotics: A Holistic Approach to Mental Health and Gut–Brain Axis Modulation submission deadline 20 Apr 2026 | Viewed by 407 | Submission Open
Keywords: probiotics; gut microbiota; gut– brain axis; mental health
(This special issue belongs to the Section Molecular Biology)
Immune Regulation During Pregnancy
edited by Sabrina Marie Scroggins
submission deadline 20 Apr 2026 | Viewed by 406 | Submission Open
Keywords: maternal– fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome
(This special issue belongs to the Section Molecular Immunology)
Advanced Nanomaterials for Bone Regeneration and Osseointegration
edited by Cristian Covarrubias
submission deadline 20 Apr 2026 | Viewed by 394 | Submission Open
Keywords: nanomaterials; bone regeneration; osseointegration; bifunctional biomaterials; bioceramics; metal nanoparticles; metal-organic frameworks (MOFs); nanostructured surfaces; composite materials; tissue engineering
(This special issue belongs to the Section Molecular Nanoscience)
Nanotechnology in Drug Delivery: Applications and Perspectives
edited by Ádám Juhász
submission deadline 20 Apr 2026 | Viewed by 390 | Submission Open
Keywords: nanostructured materials; drug delivery; drug– carrier interactions; hydrogel; aerogels; associated colloids; surfactants; macromolecules; blood– brain barrier; controlled release
(This special issue belongs to the Section Molecular Nanoscience)
New Advances in Genetic and Molecular Mechanisms Underlying Agronomic Traits in Crops
edited by Hongbin Zhang
submission deadline 20 Apr 2026 | Viewed by 374 | Submission Open
Keywords: agronomic traits; crops; vegetable crops; fruit trees; genetic; molecular; high-throughput sequencing; agronomic genes
(This special issue belongs to the Section Molecular Plant Sciences)
Attosecond Science: Toward Applications in Biology, Chemistry and Medicine
edited by
submission deadline 20 Apr 2026 | Viewed by 367 | Submission Open
Keywords: ultrafast light– matter interaction; high-harmonic generation; strong-field ionization; free-electron laser (FEL) ultrafast sources
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Mechanism of Diabetes and Its Complications
edited by Michishige Terasaki
submission deadline 20 Apr 2026 | Viewed by 363 | Submission Open
Keywords: diabetes; hyperglycemia; oxidative stress; atherosclerosis; comorbidity; complication; metabolic metabolic dysfunction associated steatotic liver disease (MASLD); steatohepatitis (MASH); chronic kidney disease (CKD); heart failure; heart failure with preserved ejection fraction (HFpEF); coronary artery disease (CAD)
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms and Non-Conventional and Complementary Treatments for Inflammatory Bowel Disease
edited by Roberta Ottria and
submission deadline 20 Apr 2026 | Viewed by 343 | Submission Open
Keywords: inflammatory bowel disease; leaky gut; molecular mechanisms; inflammatory pathways; small molecules in inflammatory bowel disease; non-conventional treatment; complementary medicine; inflammatory cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Photodiagnosis and Photodynamic Therapy submission deadline 20 Apr 2026 | Viewed by 339 | Submission Open
Keywords: photodiagnosis; photodynamic therapy; photosensitizers; natural photosensitizers; biomedical imaging; nanomedicine; targeted therapies; light as a therapeutic tool
(This special issue belongs to the Section Molecular Pharmacology)
Neurotoxicity: Cellular Death Mechanisms in the Pathogenesis of Neurodegenerative Diseases
edited by and
submission deadline 20 Apr 2026 | Viewed by 335 | Submission Open
Keywords: neurotoxicity; cellular stress; neuronal cell death; ferroptosis; neurodegeneration; neuroprotection
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Immunocytes in Cancer and New Insights into Immunotherapy
edited by Ida Franiak-Pietryga
submission deadline 20 Apr 2026 | Viewed by 331 | Submission Open
Keywords: T cells; B cells; NK cells; adoptive cell therapy; cancer; immunotherapy; checkpoint inhibitors
(This special issue belongs to the Section Molecular Immunology)
Molecular Studies in Gynecological Oncology: Advancing Diagnosis and Treatment
edited by
submission deadline 20 Apr 2026 | Viewed by 331 | Submission Open
Keywords: biomarker; cancer screening; clinical trial; DNA repair; invasion; metastasis; methylation; molecular diagnostics; molecular tumor pathology; next-generation sequencing; omics; personalized medicine; prognosis; single-cell analysis; targeted therapy; translational cancer research; treatment response; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
The Role of Macrophages in Inflammation and Cancer: An Update
edited by
submission deadline 20 Apr 2026 | Viewed by 327 | Submission Open
Keywords: macrophages; cancer; inflammation; cell therapy
(This special issue belongs to the Section Molecular Immunology)
Advanced Research on Malaria: Molecular and Biochemical Perspectives submission deadline 20 Apr 2026 | Viewed by 323 | Submission Open
Keywords: malaria; vectors; therapies; resistance; cellular mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Nanoparticle Systems for Cancer Phototherapy
edited by
submission deadline 20 Apr 2026 | Viewed by 311 | Submission Open
Keywords: nanoparticles; phototherapy; cancer; photodynamic therapy; photosensitiser molecules; biomolecules damage; DNA-intercalators; oxidative stress; cell/tissue specificity; drug delivery systems
(This special issue belongs to the Section Molecular Oncology)
Chlamydia trachomatis Pathogenicity and Disease (Third Edition) submission deadline 20 Apr 2026 | Viewed by 296 | Submission Open
Keywords: Chlamydia trachomatis; virulence factors; host susceptibility or resistance; innate and adaptive immune responses; genetic studies; cervico-vaginal microbiota; clinical outcomes with molecular study
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Genomics and Genome Editing, 3rd Edition
edited by
submission deadline 20 Apr 2026 | Viewed by 285 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Unveiling Molecular Mysteries of Brain Barriers
edited by Ana Catarina Duarte
submission deadline 20 Apr 2026 | Viewed by 284 | Submission Open
Keywords: blood– brain barrier; blood– cerebrospinal fluid barrier; arachnoid barrier; transport mechanisms; drug delivery; drug metabolism; ATP-binding cassete (ABC) transporters
(This special issue belongs to the Section Molecular Neurobiology)
Selected Papers from the 1st RNA and RNase International Meeting and Related Research
edited by
submission deadline 20 Apr 2026 | Viewed by 282 | Submission Open
Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA binding proteins; RNA recognition patterns; RNA catalysis
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria
edited by Maria Del Carmen Muñoz-Egea
submission deadline 20 Apr 2026 | Viewed by 274 | Submission Open
Keywords: mycobacteria; nontuberculous mycobacteria; Mycobacterium tuberculosis; antimicrobial resistance; drug resistance mechanisms; molecular mechanisms; antibiotic resistance
(This special issue belongs to the Section Molecular Microbiology)
Current Molecular Advances in Apoptosis submission deadline 20 Apr 2026 | Viewed by 272 | Submission Open
Keywords: apoptosis; glomerulonephritis; aging; caspase; endonuclease; DNA; cytokeratin
(This special issue belongs to the Section Biochemistry)
Application of NMR Spectroscopy in Biomolecules: 2nd Edition
edited by
submission deadline 20 Apr 2026 | Viewed by 260 | Submission Open
Keywords: advanced solution and solid state biomolecular NMR techniques; structure and dynamics of biomolecules: proteins; peptides; and nucleic acids; paramagnetic NMR; in/on cell-NMR; protein– ligand; protein– DNA; protein– RNA interaction; protein folding and misfolding; structure-based drug screening; fragment-based drug screening; computational NMR methods; sample preparation and isotope labeling strategies; NMR metabolomics and foodomics; membrane proteins and lipids; natural-abundance NMR spectroscopy; pharmaceutical NMR applications; disordered proteins and peptides; drugs development; metal-binding biomolecules; hyperpolized NMR techniques; 19F NMR spectroscopy; NMR techniques for the analysis of complex mixtures; integrated NMR-based methodologies
(This special issue belongs to the Section Molecular Biophysics)
Bioactives from Natural Products submission deadline 20 Apr 2026 | Viewed by 253 | Submission Open
Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Immunopathogenesis and Novel Therapeutic Strategies for Systemic Lupus Erythematosus: Third Edition
edited by and Hanna Przepiera-Bȩdzak
submission deadline 20 Apr 2026 | Viewed by 252 | Submission Open
Keywords: systemic lupus erythematosus; SLE pathogenesis; the epigenetic regulation of lupus; the genetic background of SLE; interferon; cytokine networks; innate immunity; adaptive immunity
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights into Sex Determination and Differentiation submission deadline 20 Apr 2026 | Viewed by 245 | Submission Open
Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution
(This special issue belongs to the Section Molecular Biology)
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