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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on Protein Structure and Protein Dynamics

edited by

Robert T. Youker

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10650 | Submission Open

Keywords: allostery; receptor; kinase; protein folding; simulations; X-ray crystallography; NMR; super-resolution imaging; fluorescence fluctuation techniques; thermodynamic; enzyme; catalysis; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Gastrointestinal Cancer: From Pathophysiology to Novel Therapeutic Approaches

edited by

Marlena Brzozowa-Zasada

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10466 | Submission Open

Keywords: gastrointestinal cancer; molecular pathology; innovative therapies; targeted therapy; immunotherapy; cancer resistance

(This special issue belongs to the Section Molecular Oncology)

Advances in Rare Diseases Biomarkers: 2nd Edition

edited by

Andrea Bernini

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10269 | Submission Open

Keywords: orphan diseases; rare diseases; inborn errors of metabolism; mitochondrial disorders; biomarker discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular and Cellular Research in Ophthalmology

edited by Zala Lužnik Marzidovšek

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10180 | Submission Open

Keywords: eye disease; ophthalmology; molecular mechanisms; cellular mechanism; stem cell therapy; tissue engineering; gene therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases

edited by

Pauline Po Yee Lui

submission deadline 20 Aug 2025 | 2 articles | Viewed by 9998 | Submission Open

Keywords: tendinopathy; tendon pain; stiffness; physical disability; etiopathogenesis; molecular mechanisms; tendon reattachment; tendon repair; advanced molecular tools; omics techniques; biophysical therapies; novel biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Study and Treatment of Motor Neuron Diseases

edited by Simona Rossi and

Savina Apolloni

submission deadline 20 Aug 2025 | 3 articles | Viewed by 9952 | Submission Open

Keywords: motor neuron; amyotrophic lateral sclerosis; neuronal degeneration; pathogenic mechanisms; molecular therapy

(This special issue belongs to the Section Molecular Neurobiology)

The Na, K-ATPase in Health and Disease

edited by

Liora Shoshani

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9885 | Submission Open

Keywords: Na+; K+-ATPase; α -subunit; β -subunit; γ subunits; FXYD

(This special issue belongs to the Section Molecular Biology)

Advances in Immunology and Inflammation During and After Infectious Diseases

edited by

Manuela Ceccarelli

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9826 | Submission Open

Keywords: bacterial infections; fungi infections; HIV; COVID-19; immune response; inflammation

(This special issue belongs to the Section Molecular Immunology)

Oxidative Stress and Inflammation in Health and Disease

edited by Fabio Vivarelli and

Donatella Canistro

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9736 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; risk factors; prevention

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Derived Food Products in the Prevention of Chronic Non-Communicable Diseases

edited by

Teresa Leszczyńska

Barbara Borczak

and

Joanna Kapusta-Duch

submission deadline 20 Aug 2025 | 7 articles | Viewed by 9698 | Submission Open

Keywords: plant foods; plant-derived foods; oxidative stress; bioactive compounds; antioxidative substances; chronic non-communicable diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances of Natural Products in Chemical and Biological Aspects

edited by

Francisco Les

Marta Sofía Valero

and

María Pilar Arruebo

submission deadline 20 Aug 2025 | 6 articles | Viewed by 9644 | Submission Open

Keywords: bioactive compounds; polyphenols; antioxidants; natural products; phytochemicals; molecular research; chemical composition; therapeutic targets; action mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biomarkers of Tumor Progression, Prognosis and Therapy: 2nd Edition

edited by

Tibor Krenacs

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9320 | Submission Open

Keywords: cancer biomarkers; genetic aberrations; carcinogenesis; cancer progression; molecular methods; in silico data analysis; image analysis; proteomics

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Treatments in Neurodegenerative Diseases

edited by

Ermanna Turano

and

Raffaella Mariotti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9316 | Submission Open

Keywords: neurodegenerative diseases; regenerative therapy; neuroprotection; neurodegeneration; pathogenetic mechanisms; cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Microbial Enzymes for Biotechnological Applications: 2nd Edition

edited by

Salvatore Fusco

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9296 | Submission Open

Keywords: microbial enzymes; whole-cell biocatalysts; extremozyme; enzyme assays; protein engineering

(This special issue belongs to the Section Biochemistry)

Neurodegenerative Diseases: New Insights into Mechanisms, Prevention, Markers, and Therapeutic Targets

edited by

Katarzyna Kaczyńska

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9120 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; molecular targets; biomarkers; disease modeling; therapeutic strategies; prevention; drug design

(This special issue belongs to the Section Molecular Neurobiology)

Autophagy and Cellular Oxidative Stress: Molecular Mechanisms and Diagnostic Biomarkers

edited by Ramona D’Amico and

Daniela Impellizzeri

submission deadline 20 Aug 2025 | 3 articles | Viewed by 9066 | Submission Open

Keywords: autophagy; oxidative stress; biomarkers; acute and chronic diseases; molecular pathways; ROS; mitophagy

(This special issue belongs to the Section Molecular Biology)

The Use of Molecular Markers in Forensic Field as an Element of Scientific Evidence

edited by

Angelo Montana

and

Margherita Neri

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8957 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Therapeutic Uses of Adult Stem Cells

edited by Leonard M. Eisenberg and Carol A. Eisenberg

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8828 | Submission Open

Keywords: adult stem cells; mesenchymal stem cells; immune response; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Wound Healing: 2nd Edition

edited by

Alina Maria Holban

and

Carmen Curutiu

submission deadline 20 Aug 2025 | 6 articles | Viewed by 8807 | Submission Open

Keywords: management of wounds; nanobiomaterials; infection control; chronic wounds; biofilm infections; wound dressings; tissue engineering; wound healing

(This special issue belongs to the Section Molecular Biology)

Breakthroughs in Diagnostic Prediction and Fundamental Therapeutics of Dementia and Movement Disorders, 2nd Edition

edited by

Yasemin M. Akay

submission deadline 20 Aug 2025 | 6 articles | Viewed by 8606 | Submission Open

Keywords: Parkinson's disease; dementia with Lewy bodies; Alzheimer's disease; pathogenic protein; biomarker; therapeutic target; drug

(This special issue belongs to the Section Molecular Neurobiology)

Bioceramics: Challenges and Medical Applications of Calcium-Phosphate-Based Biocompatible Ceramics

edited by

Kazuaki Hashimoto

and Mamoru Aizawa

submission deadline 20 Aug 2025 | 9 articles | Viewed by 8542 | Submission Open

Keywords: calcium phosphate synthesis; functional biomaterials; biological bone cements and adhesives; surface and interface properties; antibacterial and antiviral material; properties for medical applications; drug delivery properties; therapy and diagnostics; in vitro and in vivo evaluation

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Treatments of Organ Hypoxia or Ischemia

edited by

Athanasios Lourbopoulos

and

Iordanis Mourouzis

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8424 | Submission Open

Keywords: stroke; myocardial infarction; organ hypoxia; hypoxic molecular mechanisms; secondary hypoxia; inflammatory hypoxia; translational studies; diagnostic; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mast Cells in Immunity and Disease: Second Edition

edited by

Davide Firinu

Giovanni Paoletti

and

Giulia Costanzo

submission deadline 20 Aug 2025 | 5 articles | Viewed by 8399 | Submission Open

Keywords: mast-cell activation; secretion of MC-derived mediators; allergy; asthma; allergic rhinitis; urticaria; anaphylaxis; mastocytosis

(This special issue belongs to the Section Molecular Immunology)

Latest Advances in Reproduction Biology

edited by Clara Malo

submission deadline 20 Aug 2025 | 8 articles | Viewed by 8387 | Submission Open

Keywords: gamete formation; fertilization; embryo formation; embryo implantation; fertility; infertility; molecular markers; reproductive biology

(This special issue belongs to the Section Molecular Biology)

Stress Response Research: Yeast as Models: 2nd Edition

edited by

Cristina Mazzoni

and

Sergio Giannattasio

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8285 | Submission Open

Keywords: yeast; stress response; genetic disease; age-related disease; cell factory

(This special issue belongs to the Section Molecular Biology)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Basic Research to Clinical Approaches

edited by

Barbara Toffoli

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8265 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); steatosis; obesity; type 2 diabetes mellitus; therapeutic targets and interventions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional and Structural Genomics Studies for Plant Breeding

edited by

Andrea Cavallini

, Tommaso Giordani and Alberto Vangelisti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8226 | Submission Open

Keywords: plant transcriptomics; genome sequencing; plant gene function; molecular plant breeding; structural genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Biomolecular Basis of Life Processes

edited by

Janusz Błaszczyk

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8022 | Submission Open

Keywords: energy metabolism; bone-muscle interaction; ATP signalling; calcium– phosphate signalling; metabolic syndrome; aging; cellular turnover; cancers

(This special issue belongs to the Section Molecular Biology)

New Insights in Translational Bioinformatics: Second Edition

edited by

Camelia Quek

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7941 | Submission Open

Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology

(This special issue belongs to the Section Molecular Informatics)

Pathogenesis and Novel Therapeutic Approaches for Sarcomas

edited by Francisco Giner

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7917 | Submission Open

Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Function in Health and Diseases

edited by Sally P. Wheatley

submission deadline 20 Aug 2025 | 5 articles | Viewed by 7806 | Submission Open

Keywords: mitochondria; metabolism; lipid; ATP; respiration; calcium; iron; inheritance; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicity of Heavy Metal Compounds

edited by

Astrid Barkleit

submission deadline 20 Aug 2025 | 6 articles | Viewed by 7764 | Submission Open

Keywords: heavy metal; coordination; complexation; binding form; speciation; biomolecules; (cyto-) toxicity; cell death mechanism; spectroscopy; microscopy

(This special issue belongs to the Section Molecular Toxicology)

Advances and Challenges of Molecular Research on Disease in Animal Models in Biomedicine

edited by Minolfa C. Prieto

submission deadline 20 Aug 2025 | 5 articles | Viewed by 7652 | Submission Open

Keywords: animal models; cardiovascular disease; renal disease; metabolic; neurological; behavioral; and oncological disorders; pathophysiology; cell and molecular research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abiotic Stress Tolerance and Genetic Diversity in Plants, 2nd Edition

edited by

Andrés J. Cortés

submission deadline 20 Aug 2025 | 6 articles | Viewed by 7524 | Submission Open

Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Apolipoproteins and Lipoproteins in Health and Disease, 3rd Edition

edited by

Joan Carles Escolà-Gil

submission deadline 20 Aug 2025 | 5 articles | Viewed by 7323 | Submission Open

Keywords: apolipoproteins; Alzheimer's disease; atherosclerosis; cancer; cholesterol; diabetes; inflammation; obesity; lipid metabolism; lipoproteins

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Signaling Molecules Involved in Gametes Development, Differentiation and Fertilization, 2nd Edition

edited by

Sergio Minucci

and

Massimo Venditti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7317 | Submission Open

Keywords: spermatogenesis; oogenesis; spermatozoa; oocyte; fertilization; acrosome reaction; fertility; epidydimal transit; endocrine disrupting chemicals; testicular and ovarian cancer

(This special issue belongs to the Section Molecular Biology)

The Roles of Photodynamic Therapy in Tumors and Cancers

edited by Jianyong Liu

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7018 | Submission Open

Keywords: photodynamic therapy; PDT; photodetection; photosensitizers; photosensitizing agents; reactive oxygen species; molecular mechanisms; cell necrosis; apoptosis; singlet oxygen; synergetic therapy; combination therapy; delivery vehicles; immunophototherapy; nano-photosensitizer

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Gynecological Diseases—2nd Edition

edited by

David B. Alexander

submission deadline 20 Aug 2025 | 6 articles | Viewed by 6883 | Submission Open

Keywords: malignant gynecological diseases; screening for gynecological cancers; benign gynecological conditions; screening for benign gynecological diseases; endometriosis; polycystic ovaries syndrome; ovarian cysts; uterine fibroids; leiomyomas; adenomyosis; pelvic inflammatory disease; vaginitis; vaginal dysbiosis; treatment targets for gynecological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Editorial Board Members’ Collection Series: “Molecular Research in NeuroInflammation”

edited by

Ludmilla Morozova-Roche

Matthew G. Frank

and

Christina Piperi

submission deadline 20 Aug 2025 | 4 articles | Viewed by 6855 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; immune cells; Alzheimer; Parkinson

(This special issue belongs to the Section Molecular Neurobiology)

Biomarkers, Treatments, and Clinical Outcomes for Meningiomas and Other Skull Base Tumors

edited by

Michael Graner

and Philip David Tatman

submission deadline 20 Aug 2025 | 3 articles | Viewed by 6812 | Submission Open

Keywords: skull base tumor; meningioma; biomarkers; diagnosis; prognosis; radiology; surgery; pharmacotherapy; immunology

(This special issue belongs to the Section Molecular Oncology)

Insights into Chronic Liver Disease and Hepatocellular Carcinoma

edited by Marios Papadakis

submission deadline 20 Aug 2025 | 3 articles | Viewed by 6779 | Submission Open

Keywords: chronic liver disease; hepatocellular carcinoma; tumor microenvironment; viral hepatitis

(This special issue belongs to the Section Molecular Oncology)

Epilepsy Research and Antiepileptic Drugs, 2nd Edition

edited by

Sonia Mayo

submission deadline 20 Aug 2025 | 3 articles | Viewed by 6621 | Submission Open

Keywords: refractory epilepsy; pharmacoresistant epilepsy; antiepileptic drug; seizure; molecular mechanisms; prognosis; pharmacogenomics

(This special issue belongs to the Section Molecular Pharmacology)

New Molecular Mechanisms in the Development of Brain Tumors and Metastases

edited by

Raffaele Addeo

Michele Caraglia

and

Marianna Abate

submission deadline 20 Aug 2025 | 3 articles | Viewed by 6556 | Submission Open

Keywords: brain tumor; brain metastasis; blood– brain barrier; target therapy; cancer molecular biology; brain tumor microenvironment; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Aug 2025 | 2 articles | Viewed by 6517 | Submission Open

Keywords: antioxidants; metabolic pathways; oxidative stress; cellular homeostasis; redox signaling; energy metabolism; lipid metabolism; therapeutic strategies; chronic diseases

(This special issue belongs to the Section Molecular Biology)

Plant Chloroplasts and Mitochondria: Key Organelles for Sustainable Agriculture

edited by

Nunzia Scotti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 6511 | Submission Open

Keywords: ‘ omics’ ; photosynthesis; energy production; crops; climate change; sustainable agriculture; stress response; inter-organelle crosstalk; signaling networks; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction

edited by

Gundula Schulze-Tanzil

submission deadline 20 Aug 2025 | 5 articles | Viewed by 6449 | Submission Open

Keywords: cartilage; tendon; ligament; anterior cruciate ligament; bioprinting; scaffold; bioreactor; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Advances in Novel Anti-Alzheimer Drugs: Biological Target, Medicinal Chemistry and Formulation

edited by

Marc Since

and Aurélie Malzert-Fréon

submission deadline 20 Aug 2025 | 4 articles | Viewed by 6388 | Submission Open

Keywords: Alzheimer’ s disease; drug design; amyloid peptide; biological targets; medicinal chemistry; formulation

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Hormones and Nutrients in Health and Disease

edited by

Maria Scuto

submission deadline 20 Aug 2025 | 2 articles | Viewed by 6280 | Submission Open

Keywords: sensory nutrients; steroid hormones; oxidative stress; inflammation; Nrf2 pathway; neurodegenerative disorders; psychiatric diseases; personalized nutritional therapy; organoid technology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Research on the Adrenal Gland and Hormones

edited by Marcin Ruciński

submission deadline 20 Aug 2025 | 3 articles | Viewed by 6242 | Submission Open

Keywords: bioactive peptides; adrenal gland; adrenocortical carcinoma; HPA axis; G protein-coupled receptor; hormones; steroidogenesis

(This special issue belongs to the Section Molecular Pharmacology)

Mitochondria: Transport of Metabolites Across Biological Membranes

edited by

Graziantonio Lauria

and

Rosita Curcio

submission deadline 20 Aug 2025 | 3 articles | Viewed by 6190 | Submission Open

Keywords: mitochondria; mitochondrial transporters; mitochondrial metabolism; transport proteins; translocases carriers; mitochondrial carriers; mitochondrial diseases; mitochondrial permeability; apoptosis

(This special issue belongs to the Section Molecular Biology)

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