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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Nanomaterials for Cancer Treatment and Translational Medicine

edited by

Mingzhen Zhang

submission deadline 31 Dec 2025 | Viewed by 94 | Submission Open

Keywords: nanozymes; extracellular vesicles; drug delivery systems; cancer treatment; oxidative stress-related diseases; translational medicine

(This special issue belongs to the Section Molecular Nanoscience)

Genetic Variants Involved in Breast and Ovarian Cancers

edited by

Chakravarthy Garlapati

submission deadline 31 Dec 2025 | Viewed by 91 | Submission Open

Keywords: breast and ovarian cancers; genetics; genomics; biomarkers; mutations; genetic variants; translational markers

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress

edited by

Maria Giulia Lionetto

and

Maria Elena Giordano

submission deadline 31 Dec 2025 | Viewed by 90 | Submission Open

Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways

(This special issue belongs to the Section Molecular Toxicology)

Cancer Stem Cells as Key Immunotherapy Targets

edited by Cosmin Andrei Cismaru

submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open

Keywords: cancer stem cells; immunotherapy; immune escape; tumor antigens; cancer recurrence

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research on Chronic Heart Failure

edited by

Marco Tana

submission deadline 1 Jan 2026 | 3 articles | Viewed by 7108 | Submission Open

Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Poly- and Oligo-Saccharides as Pharmaceutical Agents in Biology and Medicine

edited by

Kevin H. Mayo

submission deadline 1 Jan 2026 | Viewed by 282 | Submission Open

Keywords: polysaccharides; oligosaccharides; isolation and purification; structural and functional analyses; biological mechanisms of action; cellular & molecular targets and interactions; pharmaceutical drug development; cancer; cardiovascular disease; diabetes

(This special issue belongs to the Section Molecular Biology)

Checkpoint Antibodies at the Crossroads: From Mechanisms to Multi-Modal Cancer Therapy

edited by Li Ye and Xuyao Zhang

submission deadline 10 Jan 2026 | 1 articles | Viewed by 2430 | Submission Open

Keywords: immune checkpoint inhibitors; tumor microenvironment; computational immunology; resistance mechanisms; multifunctional antibodies; rational combination design

(This special issue belongs to the Section Molecular Immunology)

From Microbes to Humans: Unveiling the Dynamic World of Carbonic Anhydrases (CAs)

edited by

Clemente Capasso

submission deadline 10 Jan 2026 | Viewed by 713 | Submission Open

Keywords: metalloenzymes; bacteria; pathogens; sulfonamides; inhibitors; activators; anti-infective agents; medicine; anticancer; neurodegenerative diseases; biomedical applications; biotechnology

(This special issue belongs to the Section Biochemistry)

Advances in Allergen Immunotherapy: Current Concepts and Future Directions

edited by

Constantinos Pitsios

submission deadline 10 Jan 2026 | Viewed by 146 | Submission Open

Keywords: allergen immunotherapy; oral immunotherapy; Hymenoptera venom; allergy extracts; adjuvants

(This special issue belongs to the Section Molecular Immunology)

Plant Epigenetic Memory Under Abiotic Stress

edited by

Md Mezanur Rahman

submission deadline 11 Jan 2026 | Viewed by 168 | Submission Open

Keywords: plant epigenetics; epigenetic memory; abiotic stress; DNA methylation; histone modification; chromatin remodeling; transgenerational inheritance; stress-responsive genes

(This special issue belongs to the Section Molecular Plant Sciences)

From Electronic Structure to Application: Computational Insights into Bioactive and Functional Molecules

edited by

Karolina Kula

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2354 | Submission Open

Keywords: molecular design; molecular modeling; substituent effect; reactivity descriptors; biological potential; in silico study; physicochemical properties; ADME; PASS; QSAR

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders

edited by Marta Pardo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 30809 | Submission Open

Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets

(This special issue belongs to the Section Molecular Neurobiology)

Natural-Derived Bioactive Compounds in Disease Treatment

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Jan 2026 | 7 articles | Viewed by 29669 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations

(This special issue belongs to the Section Molecular Pharmacology)

Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation

edited by

Masaru Tanaka

submission deadline 20 Jan 2026 | 5 articles | Viewed by 23289 | Submission Open

Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood– brain barrier; blood– cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Plant Bioactive Compounds

edited by

Karolina Wojtunik-Kulesza

submission deadline 20 Jan 2026 | 8 articles | Viewed by 22512 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition

edited by

Catherine Davis

submission deadline 20 Jan 2026 | 7 articles | Viewed by 21151 | Submission Open

Keywords: vascular permeability; atherosclerosis; blood– brain barrier; endothelial adhesion molecules; vasodilation; thrombosis

(This special issue belongs to the Section Molecular Immunology)

Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment

edited by

Ilaria Mormile

submission deadline 20 Jan 2026 | 8 articles | Viewed by 20821 | Submission Open

Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation; molecular pathway; biomarkers; target therapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms for Skin Protection and Aging

edited by Wonchul Lim and

Tae-Gyu Lim

submission deadline 20 Jan 2026 | 4 articles | Viewed by 20541 | Submission Open

Keywords: skin photo-aging; skin inflammation; molecular biology; inner beauty; natural product; skin microbiome; skin wrinkle formation; skin dehydration; skin pigmentation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

A Molecular Perspective on the Genetics of Kidney Diseases

edited by Joaquim Calado

submission deadline 20 Jan 2026 | 6 articles | Viewed by 18477 | Submission Open

Keywords: kidney; genetics; solute transport; genomics; inflammation; dysmetabolism

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Mechanisms and Therapeutics in Neurological Diseases—4th Edition

edited by

Barbara Mroczko

submission deadline 20 Jan 2026 | 8 articles | Viewed by 17938 | Submission Open

Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization (3rd Edition)

edited by

Jan Tesarik

submission deadline 20 Jan 2026 | 5 articles | Viewed by 17799 | Submission Open

Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility

(This special issue belongs to the Section Molecular Biology)

Flow Cytometry: Applications and Challenges

edited by

Alessandra Falda

submission deadline 20 Jan 2026 | 7 articles | Viewed by 17704 | Submission Open

Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies

(This special issue belongs to the Section Molecular Biology)

Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition

edited by

Bernhard Biersack

submission deadline 20 Jan 2026 | 8 articles | Viewed by 17263 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Research on Neurotransmitters

edited by

Mario Manto

Hiroshi Mitoma

and Jing-Ning Zhu

submission deadline 20 Jan 2026 | 6 articles | Viewed by 16989 | Submission Open

Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Genomic Research of Rare Diseases

edited by Shira Rockowitz and Piotr Sliz

submission deadline 20 Jan 2026 | 7 articles | Viewed by 16575 | Submission Open

Keywords: rare disease ontology; variants of uncertain significance; candidate genes; whole genome sequencing; long read whole genome sequencing; machine learning; multi-omics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies

edited by

Renata Stawerska

submission deadline 20 Jan 2026 | 8 articles | Viewed by 16369 | Submission Open

Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers

edited by

Susana Coimbra

Flávio Reis

and

Alice Santos-Silva

submission deadline 20 Jan 2026 | 6 articles | Viewed by 16222 | Submission Open

Keywords: chronic kidney disease (CKD); end-stage renal disease; CKD biomarkers; CKD progression; metabolomics; molecular pathways; biomolecules; CKD anemia; cardiovascular disease risk; CKD-related disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds in the Prevention of Chronic Diseases

edited by

Diego A. Moreno

Antonio J. Ruiz-Alcaraz

and

Paola Maycotte

submission deadline 20 Jan 2026 | 6 articles | Viewed by 15818 | Submission Open

Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Pathophysiology and Immunology Related to SARS-CoV-2 Infection

edited by

Vito D’Agnano

submission deadline 20 Jan 2026 | 9 articles | Viewed by 15641 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunology; pathophysiology; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insight into Epigenomic Studies of Human Disease

edited by

Mitsuko Masutani

and Takashi Ito

submission deadline 20 Jan 2026 | 7 articles | Viewed by 15228 | Submission Open

Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions (2nd Edition)

edited by

Manuela Dicarlo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 14708 | Submission Open

Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety

(This special issue belongs to the Section Molecular Neurobiology)

Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition

edited by

Balik Dzhambazov

submission deadline 20 Jan 2026 | 7 articles | Viewed by 14434 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into the Treatment of Metabolic Syndrome and Diabetes

edited by

Igor Kovalchuk

submission deadline 20 Jan 2026 | 5 articles | Viewed by 14321 | Submission Open

Keywords: metabolic dysfunction; metabolic disorder; diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Editorial Board Members’ Collection Series: Cardiovascular Diseases

edited by

Melania Gaggini

and

Cristina Vassalle

submission deadline 20 Jan 2026 | 5 articles | Viewed by 13680 | Submission Open

Keywords: cardiovascular disease; metabolism; cardiometabolic risk; coronary artery disease; CVD

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Zoology

edited by

Valeria Maselli

submission deadline 20 Jan 2026 | 10 articles | Viewed by 13650 | Submission Open

Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoolog

(This special issue belongs to the Section Molecular Biology)

The Structures and Biologic Activity of Marine Natural Products

edited by

Alexanra S. Silchenko

and

Vladimir Kalinin

submission deadline 20 Jan 2026 | 4 articles | Viewed by 13052 | Submission Open

Keywords: marine natural products; secondary metabolites; structure elucidation; biologic activity; structure-activity relationships; taxonomic distribution; biosynthesis; functions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research Advances in the Bioinformatics of Genome Editing and Gene Function Analysis

edited by

Hidemasa Bono

submission deadline 20 Jan 2026 | 4 articles | Viewed by 12896 | Submission Open

Keywords: genome editing; functional genomics; genome analysis; transcriptome analysis; metagenome analysis; meta-analysis; bioinformatics; large language model (LLM); public databases

(This special issue belongs to the Section Molecular Informatics)

Molecular Progression of Genetics in Breeding of Farm Animals

edited by

Karel Novák

submission deadline 20 Jan 2026 | 6 articles | Viewed by 12269 | Submission Open

Keywords: farm animal; livestock; genome sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Neurologic and Neurodegenerative Disorders

edited by

Ioana-Miruna Balmus

and

Ioannis Mavroudis

submission deadline 20 Jan 2026 | 4 articles | Viewed by 11894 | Submission Open

Keywords: traumatic brain injury; chronic traumatic encephalopathy; Alzheimer’ s disease; motor neuron disease; amyotrophic lateral sclerosis; neurosignalling; neurodegeneration; brain– gut axis impairment; oxidative stress; chronic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Bacterial Infection

edited by

María Soledad Ramírez

submission deadline 20 Jan 2026 | 5 articles | Viewed by 11717 | Submission Open

Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | 3 articles | Viewed by 11543 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Forensic Pathology and Toxicology: An Update

edited by

Angelo Montana

submission deadline 20 Jan 2026 | 5 articles | Viewed by 11474 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

New Advances in the Treatment and Diagnosis of Neuromuscular Diseases

edited by Silvia Consalvi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 11361 | Submission Open

Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance

edited by

Marzena Kurowska

and

Boris Lazarević

submission deadline 20 Jan 2026 | 4 articles | Viewed by 11053 | Submission Open

Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10997 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Developmental Biology: Computational and Experimental Approaches, 2nd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 20 Jan 2026 | 5 articles | Viewed by 10903 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations

(This special issue belongs to the Section Molecular Biology)

Natural Compounds in Human Health and Disease

edited by

Kazuhiko Nakadate

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10723 | Submission Open

Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition

edited by

Hsinjung Ho

submission deadline 20 Jan 2026 | 6 articles | Viewed by 10649 | Submission Open

Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic

(This special issue belongs to the Section Biochemistry)

Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

edited by