Special Issue "Tumor Targeting Therapy and Selective Killing"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2017).
Interests: natural product screening for anticancer; oxidative stress, antioxidant, DNA damage, apoptosis, selective killing, flow cytometry
Special Issues and Collections in MDPI journals
Tumor targeting therapies are drugs or other molecules that suppress cancer proliferation or metastasis by interacting with tumor-specific targets. To date, many tumor targeting therapies have been used in clinical cancer treatments, such as apoptosis inducers, hormone therapy, angiogenesis inhibitors, small molecule treatment, and antibody therapy. For example, cancer cells may have a tendency to escape apoptosis due to drug resistance; yet apoptosis inducers may improve the therapeutic effect of drugs by decreasing drug resistance.
Tumor targeting therapies are expected to specifically target tumor cells and interact less with normal cells than most standard chemotherapy drugs. However, tumor targeting therapies are extremely intricate and not always effective when the target is absent from the tumor. Moreover, serious side effects or treatment resistances to tumor targeting therapies may randomly appear in certain patients. Therefore, current tumor targeting therapies still have some limitations.
Recently, the combinational treatments of different tumor targeting therapies or a tumor targeting therapy combined with one or more standard chemotherapy drug have caught our attention. Accordingly, more chosen targets may be helpful to improve therapeutic effects. Moreover, natural products, or novel small molecules with selective killing inhibition of tumor cells which are less toxic to normal cells, may be effective in tumor therapy when combining tumor targeting therapies. Some natural products potentially reduce the possible side effects of tumor targeting therapies.
This Special Issue on “Tumor Targeting Therapy and Selective Killing” will explore the impact of anticancer effects and its mechanisms of action as well as drug discoveries and novel combinational treatments.
We look forward to receiving reviews and original papers depicting all aspects of tumor targeting therapies and selective killing, such as, but not limited to: tumor targeting treatment, tumor targeting modulators, selective killing agents, selective killing modulators, apoptosis inducers, drug discovery, and natural products, are welcome. We also aim to publish recent progress regarding molecular and pharmacologic aspects of this topic.
Prof. Hsueh-Wei Chang
Manuscript Submission Information
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- tumor targeting treatment
- tumor targeting modulators
- selective killing agents
- selective killing modulators
- apoptosis inducers
- drug discovery
- natural products
- combinational treatment