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TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy

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Institute of Biomedical and Genetic Engineering (IBGE), Islamabad 54000, Pakistan
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Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
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Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
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Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
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Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei 11529, Taiwan
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Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 44000, Pakistan
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Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
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Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
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Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
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Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
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Department of Radiation Oncology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan
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Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
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Department of Medical Research, Kaohsiung Medical University Hospital; Kaohsiung Medical University, Kaohsiung 80708, Taiwan
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Research Center for Natural Products & Drug Development, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
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Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
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Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(7), 1523; https://doi.org/10.3390/ijms18071523
Received: 7 June 2017 / Revised: 9 July 2017 / Accepted: 13 July 2017 / Published: 14 July 2017
(This article belongs to the Special Issue Tumor Targeting Therapy and Selective Killing)
Clinical studies and cancer cell models emphasize the importance of targeting therapies for oral cancer. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is highly expressed in cancer, and is a selective killing ligand for oral cancer. Signaling proteins in the wingless-type mouse mammary tumor virus (MMTV) integration site family (Wnt), Sonic hedgehog (SHH), and transforming growth factor β (TGFβ) pathways may regulate cell proliferation, migration, and apoptosis. Accordingly, the genes encoding these signaling proteins are potential targets for oral cancer therapy. In this review, we focus on recent advances in targeting therapies for oral cancer and discuss the gene targets within TRAIL, Wnt, SHH, and TGFβ signaling for oral cancer therapies. Oncogenic microRNAs (miRNAs) and tumor suppressor miRNAs targeting the genes encoding these signaling proteins are summarized, and the interactions between Wnt, SHH, TGFβ, and miRNAs are interpreted. With suitable combination treatments, synergistic effects are expected to improve targeting therapies for oral cancer. View Full-Text
Keywords: TRAIL; Wnt; sonic hedgehog; TGFβ; miRNA; target therapy; oral cancer TRAIL; Wnt; sonic hedgehog; TGFβ; miRNA; target therapy; oral cancer
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MDPI and ACS Style

Farooqi, A.A.; Shu, C.-W.; Huang, H.-W.; Wang, H.-R.; Chang, Y.-T.; Fayyaz, S.; Yuan, S.-S.F.; Tang, J.-Y.; Chang, H.-W. TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy. Int. J. Mol. Sci. 2017, 18, 1523. https://doi.org/10.3390/ijms18071523

AMA Style

Farooqi AA, Shu C-W, Huang H-W, Wang H-R, Chang Y-T, Fayyaz S, Yuan S-SF, Tang J-Y, Chang H-W. TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy. International Journal of Molecular Sciences. 2017; 18(7):1523. https://doi.org/10.3390/ijms18071523

Chicago/Turabian Style

Farooqi, Ammad Ahmad, Chih-Wen Shu, Hurng-Wern Huang, Hui-Ru Wang, Yung-Ting Chang, Sundas Fayyaz, Shyng-Shiou F. Yuan, Jen-Yang Tang, and Hsueh-Wei Chang. 2017. "TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy" International Journal of Molecular Sciences 18, no. 7: 1523. https://doi.org/10.3390/ijms18071523

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