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Int. J. Mol. Sci. 2017, 18(7), 1374;

The between Now and Then of Lung Cancer Chemotherapy and Immunotherapy

Institute for the Experimental Endocrinology and Oncology “G. Salvatore”, Italian National Council of Research, via S. Pansini 5, 80131 Napoli, Italy
Thoracic Surgery Unit, Antonio Cardarelli Hospital, via A. Cardarelli 9, 80131 Napoli, Italy
Authors to whom correspondence should be addressed.
Received: 5 June 2017 / Revised: 23 June 2017 / Accepted: 25 June 2017 / Published: 27 June 2017
(This article belongs to the Special Issue Tumor Targeting Therapy and Selective Killing)
Full-Text   |   PDF [205 KB, uploaded 27 June 2017]


Lung cancer is the most common cancer worldwide. Disappointingly, despite great effort in encouraging screening or, at least, a close surveillance of high-risk individuals, most of lung cancers are diagnosed when already surgically unresectable because of local advancement or metastasis. In these cases, the treatment of choice is chemotherapy, alone or in combination with radiotherapy. Here, we will briefly review the most successful and recent advances in the identification of novel lung cancer genetic lesions and in the development of new drugs specifically targeting them. However, lung cancer is still the leading cause of cancer-related mortality also because, despite impressive initial responses, the patients often develop resistance to novel target therapies after a few months of treatment. Thus, it is literally vital to continue the search for new therapeutic options. So, here, on the basis of our recent findings on the role of the tumor suppressor CCDC6 protein in lung tumorigenesis, we will also discuss novel therapeutic approaches we envision for lung cancer. View Full-Text
Keywords: lung neoplasms; antineoplastic agents; biomarkers; poly(ADP-ribose) polymerase inhibitors; CCDC6 lung neoplasms; antineoplastic agents; biomarkers; poly(ADP-ribose) polymerase inhibitors; CCDC6
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Visconti, R.; Morra, F.; Guggino, G.; Celetti, A. The between Now and Then of Lung Cancer Chemotherapy and Immunotherapy. Int. J. Mol. Sci. 2017, 18, 1374.

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