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Special Issue "TFF Peptides: Lectins in Mucosal Protection and More"
Deadline for manuscript submissions: 8 October 2019.
Prof. Dr. Werner Hoffmann Website E-Mail
Director of the Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany
Interests: protection, regeneration and repair of mucous epithelia with special emphasis on the role of TFF peptides; TFF peptides in the immune and central nervous systems
Prof. Dr. Friedrich Paulsen Website E-Mail
Head of the Institute of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsstr. 19, Erlangen 91054, Germany
Interests: protein and peptide research (mucins, TFF peptides, surfactant proteins, antimicrobial peptides, innate immune system, ocular surface, and lacrimal apparatus)
Trefoil factor family (TFF) peptides—together with mucins—are characteristic secretory products of mucous epithelia, where they are involved in different protective mechanisms. For example, they show motogenic and (anti)apoptotic activities. Furthermore, TFFs are also expressed in both the central nervous and immune systems. Pathologically, TFFs are ectopically expressed in various tumors, in inflammatory diseases, and after wounding. Transgenic TFF-deficient mice show different abnormalities in the gastrointestinal tract and the immune system, respectively. Based on these results, TFFs have considerable therapeutic potential, e.g., for treating certain inflammatory disorders as well as oral mucositis after radio- and chemotherapy. Thus far, no high-affinity binding of a TFF peptide with a classical transmembrane receptor has been identified. However, there are numerous interactions of TFFs with (glyco)proteins and a gastrokine documented. The specific interaction particularly of TFF1 and TFF2 with carbohydrate moieties clearly established them as lectins.
Papers submitted to this Special Issue must report high novelty results, e.g., concerning the complex biosynthesis of TFFs, the characterization of TFF interaction partners, the molecular function of TFFs, and the characterization of TFF modules in mosaic proteins. Additionally, state-of-the-art reviews concerning selected functional aspects of TFFs are welcome.
Prof. Dr. Werner Hoffmann
Prof. Dr. Friedrich Paulsen
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Cell migration
- Mucosal protection
- TFF domain