Special Issue "Role of Telomeres and Telomerase in Cancer and Aging 2019"
Deadline for manuscript submissions: 30 September 2019.
Dr. Gabriele Saretzki
Ageing Biology Centre and Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
Website | E-Mail
Interests: telomerase in ageing and cancer; TERT in mitochondria and brain; oxidative stress; mitochondria; senescence and ageing
Telomeres and telomerase receive ever-increasing interest from the scientific community. This includes biologists deciphering the complex mechanisms and interactions between the different components of telomeres and telomerase, as well as clinicians aiming to use telomere lengths as a biomarker for aging and diseases. Ever more details emerge about the tightly-regulated interaction of telomerase activity in the regulation of telomere lengths, and many mechanisms still remain a mystery, ready to be solved.
Telomerase activity is under tight physiological regulation in human tissues, where the enzyme is active in only a few adult tissues, such as endothelial cells and lymphocytes, but can be up-regulated in many types of adult stem cells. Telomere shortening has been associated with cellular senescence and the aging process, as well as major diseases, such as atherosclerosis, obesity, and cardiovascular disease. It is thus of high clinical relevance, and is often measured in easily-accessible blood monocytes. In contrast, telomerase activity is highly up-regulated and associated with tumorigenesis by maintaining telomeres and, thereby, constituting an important pre-requisite for the ongoing proliferation of cancer cells. Our growing understanding of the mechanisms of telomerase up-regulation during cancer development might help in tumour prognosis and in the development of new anti-cancer treatments and therapies.
In addition, many telomere-independent functions for the telomerase reverse transcriptase protein TERT have been discovered, which add to the complexity of telomerase and the multitude of its functions. It also extends the function of telomerase in its non-canonical role to cell types such as neurons, and organs such as brain.
The aim of this Special Issue is to demonstrate and share new results and the growing knowledge about the roles of telomeres and telomerase during processes such as aging and cancer development.
Dr. Gabriele Saretzki
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- telomere length
- telomerase activity
- stem cells
- cellular senescence