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Open AccessArticle

Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort

1
Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and the Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, 13353 Berlin, Germany
2
Medizinische Klinik mit Schwerpunkt Nephrologie und Intensivmedizin, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany
3
Berlin-Brandenburg Center for Regenerative Medicine (BCRT), Charité Universitätsmedizin Berlin, 13353 Berlin, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 3032; https://doi.org/10.3390/ijms20123032
Received: 29 May 2019 / Revised: 14 June 2019 / Accepted: 18 June 2019 / Published: 21 June 2019
(This article belongs to the Special Issue Role of Telomeres and Telomerase in Cancer and Aging 2019)
Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (CpGs) selected by penalized regression analysis. Here, an established methylation-sensitive single nucleotide primer extension method was adapted, to estimate the epigenetic age of the 1005 participants of the LipidCardio Study, a patient cohort characterised by high prevalence of cardiovascular disease, based on a seven CpGs epigenetic clock. Furthermore, we measured relative leukocyte telomere length (rLTL) to assess the relationship between the established and the promising new measure of biological age. Both rLTL (0.79 ± 0.14) and DNAm age (69.67 ± 7.27 years) were available for 773 subjects (31.6% female; mean chronological age= 69.68 ± 11.01 years; mean DNAm age acceleration = −0.01 ± 7.83 years). While we detected a significant correlation between chronological age and DNAm age (n = 779, R = 0.69), we found neither evidence of an association between rLTL and the DNAm age (β = 3.00, p = 0.18) nor rLTL and the DNAm age acceleration (β = 2.76, p = 0.22) in the studied cohort, suggesting that DNAm age and rLTL measure different aspects of biological age. View Full-Text
Keywords: biomarker of ageing; biological age; aging; telomere length; epigenetic clock; DNA methylation (DNAm) age; DNAm age acceleration; LipidCardio Study; Berlin Aging Study II (BASE-II) biomarker of ageing; biological age; aging; telomere length; epigenetic clock; DNA methylation (DNAm) age; DNAm age acceleration; LipidCardio Study; Berlin Aging Study II (BASE-II)
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Banszerus, V.L.; Vetter, V.M.; Salewsky, B.; König, M.; Demuth, I. Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort. Int. J. Mol. Sci. 2019, 20, 3032.

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