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Review

Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity

1
Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan
2
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan
3
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(11), 2716; https://doi.org/10.3390/ijms20112716
Received: 29 April 2019 / Revised: 30 May 2019 / Accepted: 31 May 2019 / Published: 2 June 2019
(This article belongs to the Special Issue Role of Telomeres and Telomerase in Cancer and Aging 2019)
Cellular senescence is a state of cell cycle arrest characterized by a distinct morphology, gene expression pattern, and secretory phenotype. It can be triggered by multiple mechanisms, including those involved in telomere shortening, the accumulation of DNA damage, epigenetic pathways, and the senescence-associated secretory phenotype (SASP), and so on. In current cancer therapy, cellular senescence has emerged as a potent tumor suppression mechanism that restrains proliferation in cells at risk for malignant transformation. Therefore, compounds that stimulate the growth inhibition effects of senescence while limiting its detrimental effects are believed to have great clinical potential. In this review article, we first review the current knowledge of the pro- and antitumorigeneic functions of senescence and summarize the key roles of telomerase in the regulation of senescence in tumors. Second, we review the current literature regarding the anticancer effects of stilbene compounds that are mediated by the targeting of telomerase and cell senescence. Finally, we provide future perspectives on the clinical utilization of stilbene compounds, especially resveratrol and pterostilbene, as novel cancer therapeutic remedies. We conclude and propose that stilbene compounds may induce senescence and may potentially be used as the therapeutic or adjuvant agents for cancers with high telomerase activity. View Full-Text
Keywords: senescence; telomerase; stilbene compounds; resveratrol; pterostilbene senescence; telomerase; stilbene compounds; resveratrol; pterostilbene
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MDPI and ACS Style

Lee, Y.-H.; Chen, Y.-Y.; Yeh, Y.-L.; Wang, Y.-J.; Chen, R.-J. Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity. Int. J. Mol. Sci. 2019, 20, 2716. https://doi.org/10.3390/ijms20112716

AMA Style

Lee Y-H, Chen Y-Y, Yeh Y-L, Wang Y-J, Chen R-J. Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity. International Journal of Molecular Sciences. 2019; 20(11):2716. https://doi.org/10.3390/ijms20112716

Chicago/Turabian Style

Lee, Yu-Hsuan, Yu-Ying Chen, Ya-Ling Yeh, Ying-Jan Wang, and Rong-Jane Chen. 2019. "Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity" International Journal of Molecular Sciences 20, no. 11: 2716. https://doi.org/10.3390/ijms20112716

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