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The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications

1
Pulmonary Institute, Shaare Zedek Medical Center, P.O. Box 3235, 12 Shmuel Bait St., 9103102 Jerusalem, Israel
2
Lung Cellular and Molecular Biology Laboratory, Institute of Pulmonary Medicine, Hadassah–Hebrew University Medical Center, P.O. Box 12000, Qiryat Hadassah, 91120 Jerusalem, Israel
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 2996; https://doi.org/10.3390/ijms20122996
Received: 23 May 2019 / Revised: 12 June 2019 / Accepted: 15 June 2019 / Published: 19 June 2019
(This article belongs to the Special Issue Role of Telomeres and Telomerase in Cancer and Aging 2019)
Telomeres are distal chromosome regions associated with specific protein complexes that protect the chromosome against degradation and aberrations. Telomere maintenance capacity is an essential indication of healthy cell populations, and telomere damage is observed in processes such as malignant transformation, apoptosis, or cell senescence. At a cellular level, telomere damage may result from genotoxic stress, decreased activity of telomerase enzyme complex, dysfunction of shelterin proteins, or changes in expression of telomere-associated RNA such as TERRA. Clinical evidence suggests that mutation of telomerase genes (Tert/Terc) are associated with increased risk of congenital as well as age-related diseases (e.g., pneumonitis, idiopathic pulmonary fibrosis (IPF), dyskeratosis congenita, emphysema, nonspecific interstitial pneumonia, etc.). Thus, telomere length and maintenance can serve as an important prognostic factor as well as a potential target for new strategies of treatment for interstitial lung diseases (ILDs) and associated pulmonary pathologies. View Full-Text
Keywords: telomere; interstitial lung disease; idiopathic pulmonary fibrosis; telomerase; shelterin; long noncoding RNA telomere; interstitial lung disease; idiopathic pulmonary fibrosis; telomerase; shelterin; long noncoding RNA
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Arish, N.; Petukhov, D.; Wallach-Dayan, S.B. The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications. Int. J. Mol. Sci. 2019, 20, 2996.

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