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Special Issue "Schizophrenia: Pathophysiology, Diagnostics, Therapies, and Prevention"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2017).
Schizophrenia is a chronic and debilitating mental disorder. Schizophrenia is characterized by premorbid psychological deficits, onset of psychosis in late adolescence, and psychological deterioration in adulthood. The pathophysiology of the disease involves both genes and environment. The etiology of the disease is attributed to the failure of normal neuronal development due to environmental factors or a genetic defect manifesting itself during gestation or the perinatal period. Such defects alter the development of the CNS in some way. The resulting developmental deficit accounts for the premorbid cognitive and psychosocial dysfunction in schizophrenia. Schizophrenia is characterized by positive, negative, and cognitive symptoms with poor insight and impaired psychosocial function. Although acute psychosis is controlled with pharmacotherapy, negative and cognitive symptoms tend to be unresponsive to pharmacotherapy. Impaired neurogenesis and an ineffective response to antipsychotics are thought to indicate a deteriorating course of schizophrenia. Oxidative stress and excessive dopaminergic neurotransmission create a vicious cycle and consequently disturb NMDA receptor-mediated glutamatergic neurotransmission. Recent several neuroprotective therapeutic approaches are considered efficacious for improving psychopathology in schizophrenia. Intervention strategies in adolescents at ultra high-risk for psychosis are crucial for reducing conversion to schizophrenia. Early intervention in premorbid phase of schizophrenia may improve current difficulties and prevent future schizophrenia using adequate treatments. In this Special Issue, we aimed to focus on causes, diagnosis, treatments and prevention in schizophrenia.
Prof. Dr. Yong-Ku Kim
Manuscript Submission Information
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