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Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk

Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada
Author to whom correspondence should be addressed.
Academic Editor: Yong-Ku Kim
Int. J. Mol. Sci. 2017, 18(3), 651;
Received: 20 December 2016 / Revised: 7 March 2017 / Accepted: 15 March 2017 / Published: 17 March 2017
PDF [383 KB, uploaded 17 March 2017]


Although our understanding of psychotic disorders has advanced substantially in the past few decades, very little has changed in the standard of care for these illnesses since the development of atypical anti-psychotics in the 1990s. Here, we integrate new insights into the pathophysiology with the increasing interest in early detection and prevention. First, we explore the role of N-methyl-d-aspartate receptors in a subpopulation of cortical parvalbumin-containing interneurons (PVIs). Postmortem and preclinical data has implicated these neurons in the positive and negative symptoms, as well as the cognitive dysfunction present in schizophrenia. These neurons also appear to be sensitive to inflammation and oxidative stress during the perinatal and peripubertal periods, which may be mediated in large part by aberrant synaptic pruning. After exploring some of the molecular mechanisms through which neuroinflammation and oxidative stress are thought to exert their effects, we highlight the progress that has been made in identifying psychosis prior to onset through the identification of individuals at clinical high risk for psychosis (CHR). By combining our understanding of psychosis pathogenesis with the increasing characterization of endophenotypes that precede frank psychosis, it may be possible to identify patients before they present with psychosis and intervene to reduce the burden of the disease to both patients and families. View Full-Text
Keywords: schizophrenia; psychosis; neuroinflammation; oxidative stress schizophrenia; psychosis; neuroinflammation; oxidative stress

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Barron, H.; Hafizi, S.; Andreazza, A.C.; Mizrahi, R. Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk. Int. J. Mol. Sci. 2017, 18, 651.

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