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Int. J. Mol. Sci. 2013, 14(8), 16168-16183;

Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Author to whom correspondence should be addressed.
Received: 9 July 2013 / Revised: 23 July 2013 / Accepted: 25 July 2013 / Published: 5 August 2013
(This article belongs to the Special Issue Post-Transcriptional Gene Regulation by Ribonucleoprotein Complexes)
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Gene expression is intricately regulated at the post-transcriptional level by RNA-binding proteins (RBPs) via their interactions with pre-messenger RNA (pre-mRNA) and mRNA during development. However, very little is known about the mechanism regulating RBP activities in RNA metabolism. During the past few years, a large body of evidence has suggested that many RBPs, such as heterogeneous nuclear ribonucleoproteins (hnRNPs), undergo post-translational modification through poly(ADP-ribosyl)ation to modulate RNA processing, including splicing, polyadenylation, translation, miRNA biogenesis and rRNA processing. Accordingly, RBP poly(ADP-ribosyl)ation has been shown to be involved in stress responses, stem cell differentiation and retinal morphogenesis. Here, we summarize recent advances in understanding the biological roles of RBP poly(ADP-ribosyl)ation, as controlled by Poly(ADP-ribose) Polymerases (PARPs) and Poly(ADP-ribose) Glycohydrolase (PARG). In addition, we discuss the potential of PARP and PARG inhibitors for the treatment of RBP-related human diseases, including cancer and neurodegenerative disorders. View Full-Text
Keywords: Parp; Parg; poly(ADP-ribose); RNA-binding protein; RNA metabolism Parp; Parg; poly(ADP-ribose); RNA-binding protein; RNA metabolism
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ji, Y.; Tulin, A.V. Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins. Int. J. Mol. Sci. 2013, 14, 16168-16183.

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