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Open AccessReview

RNA Binding Proteins in the miRNA Pathway

Faculty of Science 1, University of Technology, Sydney, NSW 2007, Australia
Faculty of Engineering and Information technology 2, University of Technology, Sydney, NSW 2007, Australia
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Kotb Abdelmohsen
Int. J. Mol. Sci. 2016, 17(1), 31;
Received: 9 November 2015 / Revised: 13 December 2015 / Accepted: 23 December 2015 / Published: 26 December 2015
(This article belongs to the Special Issue Post-Transcriptional Gene Regulation by Ribonucleoprotein Complexes)
PDF [1401 KB, uploaded 26 December 2015]


microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets. View Full-Text
Keywords: miRNA; RNA binding protein; Drosha; Dicer; Argonaute; cross-linking and immonoprecipitation (CLIP) miRNA; RNA binding protein; Drosha; Dicer; Argonaute; cross-linking and immonoprecipitation (CLIP)

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Connerty, P.; Ahadi, A.; Hutvagner, G. RNA Binding Proteins in the miRNA Pathway. Int. J. Mol. Sci. 2016, 17, 31.

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