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p53 as a Regulator of Lipid Metabolism in Cancer

Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
Author to whom correspondence should be addressed.
Academic Editor: Gregor Drummen
Int. J. Mol. Sci. 2016, 17(12), 2074;
Received: 8 October 2016 / Revised: 1 December 2016 / Accepted: 6 December 2016 / Published: 10 December 2016
(This article belongs to the Special Issue Emerging Non-Canonical Functions and Regulation of p53)
PDF [937 KB, uploaded 10 December 2016]


Enhanced proliferation and survival are common features of cancer cells. Cancer cells are metabolically reprogrammed which aids in their survival in nutrient-poor environments. Indeed, changes in metabolism of glucose and glutamine are essential for tumor progression. Thus, metabolic reprogramming is now well accepted as a hallmark of cancer. Recent findings suggest that reprogramming of lipid metabolism also occurs in cancer cells, since lipids are used for biosynthesis of membranes, post-translational modifications, second messengers for signal transduction, and as a source of energy during nutrient deprivation. The tumor suppressor p53 is a transcription factor that controls the expression of proteins involved in cell cycle arrest, DNA repair, apoptosis, and senescence. p53 also regulates cellular metabolism, which appears to play a key role in its tumor suppressive activities. In this review article, we summarize non-canonical functions of wild-type and mutant p53 on lipid metabolism and discuss their association with cancer progression. View Full-Text
Keywords: p53; lipid metabolism; cancer; mevalonate pathway; fatty acid oxidation p53; lipid metabolism; cancer; mevalonate pathway; fatty acid oxidation

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Parrales, A.; Iwakuma, T. p53 as a Regulator of Lipid Metabolism in Cancer. Int. J. Mol. Sci. 2016, 17, 2074.

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