Next Article in Journal
The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search
Next Article in Special Issue
Recognition of Local DNA Structures by p53 Protein
Previous Article in Journal
Three-Dimensional Electrodes for High-Performance Bioelectrochemical Systems
Previous Article in Special Issue
p53 as a Regulator of Lipid Metabolism in Cancer
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(1), 93;

Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Authors to whom correspondence should be addressed.
Academic Editor: Tomoo Iwakuma
Received: 4 October 2016 / Revised: 21 December 2016 / Accepted: 21 December 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Emerging Non-Canonical Functions and Regulation of p53)
Full-Text   |   PDF [407 KB, uploaded 12 January 2017]   |  


While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5′-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics. View Full-Text
Keywords: p53; internal ribosome entry site (IRES); DNA damage; IRES-trans acting factors (ITAFs) p53; internal ribosome entry site (IRES); DNA damage; IRES-trans acting factors (ITAFs)

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ji, B.; Harris, B.R.E.; Liu, Y.; Deng, Y.; Gradilone, S.A.; Cleary, M.P.; Liu, J.; Yang, D.-Q. Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics. Int. J. Mol. Sci. 2017, 18, 93.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top