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Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Authors to whom correspondence should be addressed.
Academic Editor: Tomoo Iwakuma
Int. J. Mol. Sci. 2017, 18(1), 93;
Received: 4 October 2016 / Revised: 21 December 2016 / Accepted: 21 December 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Emerging Non-Canonical Functions and Regulation of p53)
While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5′-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics. View Full-Text
Keywords: p53; internal ribosome entry site (IRES); DNA damage; IRES-trans acting factors (ITAFs) p53; internal ribosome entry site (IRES); DNA damage; IRES-trans acting factors (ITAFs)
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MDPI and ACS Style

Ji, B.; Harris, B.R.E.; Liu, Y.; Deng, Y.; Gradilone, S.A.; Cleary, M.P.; Liu, J.; Yang, D.-Q. Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics. Int. J. Mol. Sci. 2017, 18, 93.

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