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Special Issue "Proteomics and Metabonomics for Personalised Medicine"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2185

Special Issue Editors

Prof. Dr. Andrea Urbani
E-Mail Website
Guest Editor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
Interests: proteomics; metabonomics; small molecules; mass spectrometry; personalized medicine; drug discovery
Prof. Dr. Federica Iavarone
E-Mail Website
Guest Editor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
Interests: human proteomics; metabonomics; small molecules; mass spectrometry; biomarkers

Special Issue Information

Dear Colleagues,

A number of physiological and pathological conditions are characterized by dynamic remodeling of the proteome and with a deep modification in the concentration of metabolites in the organism.

Molecular phenotyping, in particular proteomics and metabolomics, offers great promise in this field. Indeed, on one hand, they lead to the discovery of new, biologically and clinically relevant biomarkers, for personalizing preventive and therapeutic interventions. On the other hand, they contribute new knowledge in terms of molecular mechanisms. Furthermore, the combined integrative genomics approaches with proteo-metabolomic investigations are developing rapidly and are particularly relevant in the understanding of several pathologies.

For this Special Issue, we invite authors to contribute original research articles, method papers, as well as review articles that will address recent developments in the area of proteomics and metabolomics.

Potential topics include but are not limited to the following:

Reference standards and intervals for clinical proteomics;
Integrative genomics on the verge of proteomics and metabolomics;
Novel mass spectrometry methods for clinical practice;
Bioinformatics for the analysis of proteomics and metabolomics data;
Molecular protein networks;
Targeted, untargeted metabolomics;
II order molecular cybernetics mechanisms.

Prof. Dr. Andrea Urbani
Prof. Dr. Federica Iavarone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Personalized medicine
  • Molecular phenotyping
  • Proteogenomics
  • Systems biology and medicine
  • Mass spectrometry

Published Papers (1 paper)

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Research

Article
Multi-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation
Int. J. Mol. Sci. 2021, 22(21), 11678; https://doi.org/10.3390/ijms222111678 - 28 Oct 2021
Cited by 1 | Viewed by 1281
Abstract
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approaches. [...] Read more.
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approaches. To identify molecular networks and pathways which may play important roles in intervertebral disc herniation, as well as to reveal the potential features which could be useful for monitoring disease progression and prognosis, multi-omics profiling, including high-resolution liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and tandem mass tag (TMT)-based proteomics was performed. Cerebrospinal fluid of nine dogs with IVDH and six healthy controls were used for the analyses, and an additional five IVDH samples were used for proteomic data validation. Furthermore, multi-omics data were integrated to decipher a complex interaction between individual omics layers, leading to an improved prediction model. Together with metabolic pathways related to amino acids and lipid metabolism and coagulation cascades, our integromics prediction model identified the key features in IVDH, namely the proteins follistatin Like 1 (FSTL1), secretogranin V (SCG5), nucleobindin 1 (NUCB1), calcitonin re-ceptor-stimulating peptide 2 precursor (CRSP2) and the metabolites N-acetyl-D-glucosamine and adenine, involved in neuropathic pain, myelination, and neurotransmission and inflammatory response, respectively. Their clinical application is to be further investigated. The utilization of a novel integrative interdisciplinary approach may provide new opportunities to apply innovative diagnostic and monitoring methods as well as improve treatment strategies and personalized care for patients with degenerative spinal disorders. Full article
(This article belongs to the Special Issue Proteomics and Metabonomics for Personalised Medicine)
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