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Special Issue "Molecular Biocatalysis 2.0"
Deadline for manuscript submissions: 7 March 2020.
Interests: Biocatalysis and biotransformation; immobilized microbial cells, their use in production and biotransformation of natural products; biotransformation of natural products by enzymes and microorganisms; preparation of glycosidases of microbial origin and their use for glycosylation of natural compounds: glycoconjugates, multivalent compounds, ergot alkaloids, flavonoids, antioxidants and chemoprotectants
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: The Lignin Challenge: Exploring Innovative Applications
Special Issue in International Journal of Molecular Sciences: Molecular Transformations of Natural Products
Interests: biocatalysis and biotransformation by enzymes and whole cells; glycosidases; glycosyltransferases; sulfatases and sulfotransferases; nitrilases; site-directed mutagenesis and directed evolution of enzymes; engineering of enzymatic reactions; enzymatic synthesis of oligosaccharides; glycoconjugates; glycobiomaterials; glycopolymers; enzyme inhibitors and time-dependent inactivators; analysis of enzyme active site
For over a century, biocatalysis has been a prominent area of biotechnology. This year, its utmost importance has been highlighted by the award of the Nobel Prize in Chemistry to Frances H. Arnold for the directed evolution of enzymes. Advanced enzymatic synthesis performed by cascades of tailored catalysts or by programmed whole-cell factories can yield specific products with astonishing bioactivities. The strategy for designing these new platforms involves the analysis of enzymatic systems in vivo, the development and discovery of new biocatalysts to fill the enzyme toolbox for chemistry, and their in vitro assembly into novel synthetic reaction pathways. These tasks are highly multidisciplinary, covering microbiology, protein chemistry, molecular biology, bioinformatics, and data mining, as well as chemistry of acquired products. Topics for this Special Issue include the discovery of new biocatalysts, the biocatalyst engineering for alteration and optimization of their function, use of site-directed mutagenesis and directed evolution for the construction of novel catalytic tools, biocatalytic preparation of new bioactive compounds, cascade, one-pot, and telescoping reactions, biotechnologically attractive enzyme reactions.
Major requirements for papers submitted to this Special Issue are (i) clear novelty; (ii) reproducibility; (iii) molecular bases of reactions and processes; and (iv) defined chemical reactions and structures. Publication of primary sequences of respective proteins used is strongly encouraged. Papers dealing with minor optimizations of known procedures, those using poorly defined organisms or organisms unavailable to other researchers or containing poorly defined substrates and products will be returned without further review.
Prof. Dr. Vladimír Křen
Dr. Pavla Bojarová
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Biocatalyst discovery
- Biocatalyst development, design and engineering
- Cofactor regeneration and multienzyme processes
- Fundamentals of biocatalysis
- New solvents and special processes for biocatalysis
- Integration of biocatalysis into chemical processes