Special Issue "Molecular Mechanisms of Host Range and Pathogenicity of Influenza Viruses"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2017).
Interests: role of hemagglutinin and neuraminidase of influenza viruses in host range, cell tropism and pathogenicity
Interests: role of viral and host factors in pathogenicity and host range of emerging viruses
A large variety of influenza A viruses with 16 HA and 9 NA subtypes circulate in the major natural reservoir in aquatic birds. These viruses occasionally transmit and form stable lineages in other avian and mammalian species. Adaptation to domestic animals enhances chances of zoonotic transmission. On rare occasions, transmission and adaptation to humans of the virus with an antigenically novel HA initiates a pandemic. Following the pandemic, viruses continue to circulate in human population, causing annual seasonal influenza outbreaks. The pathogenesis of influenza varies widely depending on the virus and the animal or human host from unapparent infection to severe and fatal disease. The viral host range and pathogenesis are the result of complex interplay between virus and host at the systemic, the cellular and the molecular levels, and it involves the interaction of viral proteins with many host factors. Current understanding of these interactions is far from complete. This Special Issue will focus on mechanisms underlying cell and tissue tropism, spread of infection, virus load, escape of host defense, modification of inflammatory response, and synergism between viruses and bacteria. Original research and reviews on these and related topics in this area are invited.
Dr. Mikhail Matrosovich
Prof. Dr. Hans-Dieter Klenk
Manuscript Submission Information
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- interspecies transmission
- zoonoses, pandemics
- innate immunity