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Int. J. Mol. Sci. 2017, 18(8), 1631;

Host Response Comparison of H1N1- and H5N1-Infected Mice Identifies Two Potential Death Mechanisms

VIM, INRA, Université Paris-Saclay, Jouy-en-Josas, Paris 78350, France
Département de Virologie, Unité de Génétique Moléculaire des Virus à ARN, Institut Pasteur, Paris 75015, France
Current address: DBV Technologies, 177-181 avenue Pierre Brossolette, Montrouge 92120, France.
Author to whom correspondence should be addressed.
Received: 29 May 2017 / Revised: 12 July 2017 / Accepted: 20 July 2017 / Published: 27 July 2017
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Highly pathogenic influenza A viruses (IAV) infections represent a serious threat to humans due to their considerable morbidity and mortality capacities. A good understanding of the molecular mechanisms responsible for the acute lung injury observed during this kind of infection is essential to design adapted therapies. In the current study, using an unbiased transcriptomic approach, we compared the host-responses of mice infected with two different subtypes of IAV: H1N1 vs. H5N1. The host-response comparison demonstrated a clear difference between the transcriptomic profiles of H1N1- and H5N1-infected mice despite identical survival kinetics and similar viral replications. The ontological analysis of the two transcriptomes showed two probable causes of death: induction of an immunopathological state of the lung for the H1N1 strain vs. development of respiratory dysfunction in the case of the H5N1 IAV. Finally, a clear signature responsible for lung edema was specifically associated with the H5N1 infection. We propose a potential mechanism of edema development based on predictive bioinformatics tools. View Full-Text
Keywords: influenza virus; host response; mouse model; transcriptome; H5N1; H1N1 influenza virus; host response; mouse model; transcriptome; H5N1; H1N1

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Leymarie, O.; Meyer, L.; Hervé, P.-L.; Da Costa, B.; Delmas, B.; Chevalier, C.; Le Goffic, R. Host Response Comparison of H1N1- and H5N1-Infected Mice Identifies Two Potential Death Mechanisms. Int. J. Mol. Sci. 2017, 18, 1631.

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