Esterases in the Circulatory System: Structure, Function, Activity Modulation and Involvement in Pathology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 21111
Special Issue Editor
Interests: medicinal chemistry; chemical biology; drug and nucleic acid delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The circulatory system contains a plethora of esterases, which are enzymes specialized in cleaving various esters that are normally and recurrently present in circulation as part of the body homeostasis or that can appear transiently due to diet, various dysfunction or diseases. Due to the large range of lipophilicity of the substrates that can be normally or potentially present in the bloodstream, the circulatory system displays a wide range of esterases, either solubilized in blood/plasma, attached on the blood vessel walls and/or encapsulated into various cells present in the bloodstream (red blood cells, platelets, leukocytes, etc.). The proposed thematic issue aims to detail their structure and mechanism of action as a function of the lipophilicity of the esters processed and their physiologic role(s) in the circulatory system. Special emphasis will be placed on the involvement of different circulatory system esterases in diseases and their activity modulation (inhibition/activation) for therapeutic purposes.
Prof. Dr. Marc A. Ilies
Guest Editor
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Keywords
- esterases and lipases
- circulatory system
- blood, plasma, blood vessels, figurative elements of blood
- physiopathology
- structure and catalysis mechanism
- substrate selectivity
- activity assays
- inhibition and activation
- drugs in clinical use and under development
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