Special Issue "Molecular Research on Drug Induced Liver Injury"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2017).
Interests: alcoholic liver disease; alcoholic liver injury; alcohol metabolism; microsomal ethanol-oxidizing system; drug induced liver injury; herb induced liver injury; herbal traditional Chinese medicine (TCM); dietary supplements; causality assessment
Special Issues and Collections in MDPI journals
Special Issue in Medicines: Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity
Special Issue in International Journal of Molecular Sciences: Hepatotoxicity: Molecular Mechanisms and Pathophysiology
Special Issue in International Journal of Molecular Sciences: Alcoholic Liver Injury: Metabolism, Molecular Mechanisms, and Cascade of Events
Special Issue in Biomedicines: Alcoholic Liver Disease: Diagnostics and Therapeutics
Interests: drug induced liver injury (DILI); hepatotoxicity causality assessment; Roussel Uclaf Causality Assessment (RUCAM); pharmacovigilance; drug hepatotoxicity; drug safety; adverse drug reactions
Drugs may cause liver injury in a few susceptible individuals, but the molecular events that lead to this idiosyncratic, dose independent and non-predictable drug induced liver injury (DILI) are mostly unknown since animal models to explore the pathogenetic mechanisms are not yet reliable. Little more is known about molecular events in connection with the intrinsic, dose dependent DILI since animal studies can clarify some questions of the underlying pathogenetic conditions. Molecular risk factors of idiosyncratic DILI include drug lipophilicity, high daily dose, and high metabolic rate, in addition to genetic factors that may initiate liver injury. Nevertheless, many pathogenetic challenges at the molecular level remain unknown. Uncertainties also relate to possible molecular diagnostic biomarkers, whether these could assist RUCAM (Roussel Uclaf Causality Assessing Method) to establish causality for suspected drugs in DILI cases. Clearly, much more research is still warranted to elucidate molecular pathogenetic events in DILI which may help to establish diagnostic biomarkers. The aim of this Special Issue is to provide a broad updated overview on these molecular related hepatotoxicity features with their challenges and highlights and to encourage more molecular research in DILI. We, therefore, asked experts in the field to contribute with their views to this emerging and fascinating topic of molecular aspects. Since some topics are still controversial, we expect and appreciate lively discussions, in addition to well-settled issues that are relevant to the clinical setting of molecular DILI and require balanced statements.
Prof. Dr. Rolf Teschke
Dr. Gaby Danan
Manuscript Submission Information
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- drug induced liver injury (DILI)
- drug hepatotoxicity
- drug lipophilicity
- drug metabolism
- daily drug dose
- diagnostic biomarkers
- molecular DILI pathophysiology