Special Issue "Pathogenesis and Prevention of Colorectal Cancer"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 July 2013).
Interests: colorectal cancer; colitis associated cancer; cancer chemoprevention; DNA damage response; genetic instability; inflammatory bowel diseases; iron and colorectal cancer; iron deficient megakaryopoiesis; IL-10 signaling; mucosal immunology; mesalamine; microsatellite instability; natural compounds; P-21-activated kinase-1; endoscopy; iron therapy
Interests: colorectal cancer; colitis associated cancer; cancer chemoprevention; DNA damage response; genetic instability; inflammatory bowel diseases; iron and colorectal cancer; iron deficient megakaryopoiesis; IL-10 signaling; mucosal immunology; mesalamine; microsatellite instability; natural compounds; P-21-activated kinase-1
Colorectal cancer is one of the leading causes of mortality in the western world. A better understanding of the pathogenesis of colorectal cancer will help to improve preventive measures and thereby reduce cancer incidence. While there is not just a single cause predisposing to cancer; intestinal polyps, genetic syndromes (FAP, HNPCC), chronic inflammation (such as IBD), diet and lifestyle; all impose risk to the pathogenesis and development of colorectal cancer.
We invite investigators working in the field of pathogenesis and prevention of colorectal cancer, to submit original papers or reviews highlighting the epidemiology, pathogenesis, management and prevention of colorectal carcinogenesis to further enhance our understanding of the state of art in this field. The topics of interest could include, but are not limited to:
- Somatic and genetic determinants in derangement of intestinal homeostasis
- Role of inflammation in initiation and progression of colorectal cancer
- Hereditary cancer syndromes
- Phenotypic and molecular presentation of the disease
- Mechanistic studies on colorectal carcinogenesis
- Prognostic and predictive biomarkers reflecting qualitative and quantitative disease activity, progression of cancer and prediction of the outcome of the treatment
- The rationale of prevention and interruption of colorectal carcinogenesis
- Prospects for new preventive strategies including dietary or lifestyle changes, nutritional supplements, natural compounds or pharmaceuticals
Prof. Dr. Christoph Gasche
Dr. Vineeta Khare
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access semimonthly journal published by MDPI.
- colorectal cancer
- colitis-associated cancer
- hereditary cancer syndromes
- microsatellite instability
- chromosomal instability
- CpG island methylator phenotype
- DNA repair