Next Article in Journal
Decreased Expression of Alpha-L-Fucosidase Gene FUCA1 in Human Colorectal Tumors
Next Article in Special Issue
Potential Targets for Colorectal Cancer Prevention
Previous Article in Journal
MicroRNA-143 Downregulates Interleukin-13 Receptor Alpha1 in Human Mast Cells
Previous Article in Special Issue
Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention
Open AccessArticle

Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines

1
Department of Biological Sciences, Konkuk University, Seoul 143-701, Korea
2
Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Korea
3
Department of Applied Chemistry, Dongduk Women's University, Seoul 136-714, Korea
4
National Institute of Animal Science, Rural Development Administration, Suwon 441-706, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2013, 14(8), 16970-16985; https://doi.org/10.3390/ijms140816970
Received: 5 July 2013 / Revised: 6 August 2013 / Accepted: 9 August 2013 / Published: 19 August 2013
(This article belongs to the Special Issue Pathogenesis and Prevention of Colorectal Cancer)
Plant-derived polyphenols are being tested as chemopreventive agents; some polyphenols arrest the cell cycle at G1 phase, whereas others inhibit cell cycle proliferation at G2/M phase. Therefore, polyphenols have been proposed to inhibit cell cycle progression at different phases via distinct mechanisms. Indeed, our previous studies showed that small structural differences in polyphenols cause large differences in their biological activities; however, the details of the structural properties causing G1 cell cycle arrest remain unknown. In this study, we prepared 27 polyphenols, including eight different scaffolds, to gain insight into the structural conditions that arrest the cell cycle at G1 phase in a quantitative structure–activity relationship study. We used cell cycle profiles to determine the biophores responsible for G1 cell cycle arrest and believe that the biophores identified in this study will help design polyphenols that cause G1 cell cycle arrest. View Full-Text
Keywords: polyphenols; flavonoids; colorectal cancer; cell cycle; QSAR polyphenols; flavonoids; colorectal cancer; cell cycle; QSAR
MDPI and ACS Style

Shin, S.Y.; Yoon, H.; Ahn, S.; Kim, D.-W.; Bae, D.-H.; Koh, D.; Lee, Y.H.; Lim, Y. Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines. Int. J. Mol. Sci. 2013, 14, 16970-16985. https://doi.org/10.3390/ijms140816970

AMA Style

Shin SY, Yoon H, Ahn S, Kim D-W, Bae D-H, Koh D, Lee YH, Lim Y. Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines. International Journal of Molecular Sciences. 2013; 14(8):16970-16985. https://doi.org/10.3390/ijms140816970

Chicago/Turabian Style

Shin, Soon Y.; Yoon, Hyuk; Ahn, Seunghyun; Kim, Dong-Wook; Bae, Dong-Ho; Koh, Dongsoo; Lee, Young H.; Lim, Yoongho. 2013. "Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines" Int. J. Mol. Sci. 14, no. 8: 16970-16985. https://doi.org/10.3390/ijms140816970

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop