Special Issue "Cancer Epigenetics"
Deadline for manuscript submissions: closed (30 April 2017).
Prof. Dr. Nicoletta Sacchi
Epigenetic modifications, recognized for playing a fundamental role in human development, play also a relevant role in the initiation and progression of complex degenerative diseases and cancer. These modifications, differently from genetic modifications, do not affect the sequence of DNA, but they can affect gene expression. In the prenatal period and throughout its lifetime the human genome is influenced by both genetic and environmental factors (e.g., diet) which can conspire with inherited genetic variation and acquired somatic genetic mutations to destabilize normal checks and balances of cells, thus predisposing/leading to cancer. Thus, cancer prevention and treatment could be greatly improved by understanding the relative contribution of both genetic and environmental factors to epigenetic modifications of the genome.
The many different epigenetic mechanisms that drive normal developmental processes when go awry can not only lead to human cancer initiation and progression, but can also confer cancer cell resistance to growth inhibitory physiological signals and drugs.
The aim of this Special Issue is to provide a broad overview on the topic of “Cancer Epigenetics” in the context of human cancer, cancer models systems, drug resistance, and therapy, and cancer epitranscriptomics. To this end, we welcome experts in the field to contribute research papers and critical reviews on the various facets of epigenetics in cancer.
Prof. Dr. Nicoletta Sacchi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA hypomethylation and hypermethylation
- histone modifications
- chromatin modifying enzymes
- epigenetic regulation of transcription
- non-coding RNAs
- epigenetic diagnostics
- epigenetic therapy