Special Issue "Cancer Epigenetics"
Deadline for manuscript submissions: closed (30 April 2017) | Viewed by 90117
Interests: genome wide epigenetic control of transcription;transcription factors and nuclear receptors; regulatory RNAs
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Topical Collection in Cancers: Regulatory and Non-Coding RNAs in Cancer Epigenetic Mechanisms
Epigenetic modifications, recognized for playing a fundamental role in human development, play also a relevant role in the initiation and progression of complex degenerative diseases and cancer. These modifications, differently from genetic modifications, do not affect the sequence of DNA, but they can affect gene expression. In the prenatal period and throughout its lifetime the human genome is influenced by both genetic and environmental factors (e.g., diet) which can conspire with inherited genetic variation and acquired somatic genetic mutations to destabilize normal checks and balances of cells, thus predisposing/leading to cancer. Thus, cancer prevention and treatment could be greatly improved by understanding the relative contribution of both genetic and environmental factors to epigenetic modifications of the genome.
The many different epigenetic mechanisms that drive normal developmental processes when go awry can not only lead to human cancer initiation and progression, but can also confer cancer cell resistance to growth inhibitory physiological signals and drugs.
The aim of this Special Issue is to provide a broad overview on the topic of “Cancer Epigenetics” in the context of human cancer, cancer models systems, drug resistance, and therapy, and cancer epitranscriptomics. To this end, we welcome experts in the field to contribute research papers and critical reviews on the various facets of epigenetics in cancer.
Prof. Dr. Nicoletta Sacchi
Manuscript Submission Information
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- DNA hypomethylation and hypermethylation
- histone modifications
- chromatin modifying enzymes
- epigenetic regulation of transcription
- non-coding RNAs
- epigenetic diagnostics
- epigenetic therapy