Cancer Epigenetics 2018

Dear Colleagues,

Epigenetic mechanisms, recognized for playing a fundamental role in human development, play a relevant role in the initiation and progression of cancer. In the prenatal period, and throughout the lifetime, our genome is influenced by both the intrinsic genetic environment and a multitude of factors of the external environment. The many different epigenetic mechanisms that govern normal developmental processes—in space and time, when go awry—not only trigger cancer initiation and drive cancer progression, but also confer resistance to physiological signals, which are naturally meant to deter and protect our cells from becoming cancer cells.

Developmental processes and cancer are intimately linked. Thus, the focus of this second “Cancer Epigenetics” Special Issue of the International Journal of Molecular Sciences (IJMS) is on molecular cell mechanisms connecting normal development and cancer, with emphasis on the interplay of diverse epigenetic components, including chromatin modifiers and the multitude of regulatory noncoding RNAs. To this end, we welcome provocative commentaries, reviews and challenging research articles on the “epigenetic basis of cancer”.

Looking forward to new submissions coming from all over the world.

Sincerely,

Prof. Dr. Nicoletta Sacchi
Guest Editor

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