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Special Issue "Oxidative Stress and Brain Injury"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (22 December 2019).
Interests: forensic pathology; sudden cardiac death & molecular mechanisms; traumatic brain injury & oxidative stress; immunohistochemistry; drugs of abuse & oxidative stress; maternal mortality; miRNA & forensic pathologies
Interests: forensic neuropathology, traumatic brain injury, drugs of abuse, forensic histopathology
Scientific literature gave extensive prominence about the effects of reactive oxygen species (ROS) induced oxidative stress and its fatal effects on brain after injury by endogenous factors, traumatic brain injury, and degenerative neural injury eventually due to ROS. Oxidative stress is an event caused by an imbalance between biochemical processes leading to the production of ROS and those responsible for the removal of ROS, known as the enzymatic and non-enzymatic antioxidant cellular defense systems. The excessive production of ROS due to excitotoxicity and depletion of the endogenous antioxidant system induces peroxidation of cellular and vascular structures, protein oxidation, and inhibition of the mitochondrial electron transport chain, causing oxidative cellular damage. Oxidative stress induces cell membrane lipoperoxidation and calcium release, which activates calpain. ROS and RNS induced oxidative damage in neuronal mitochondria and compromise Ca2+ homeostasis. Increase in the defense mechanisms through the use of exogenous antioxidants may be neuroprotective, particularly if they are given within the neuroprotective time window. As example, a promising potential therapeutic target in DAI is to directly address mitochondria related injury or to modulate energetic axonal energy failure. However, dietary supplementation with antioxidant and the use of pharmacological agents targeting oxidative stress seem logical but the benefits of proven antioxidant strategies have not been clearly demonstrated to date.
In this Special Issue on “Oxidative Stress and Brain Injury”, we invite front-line researchers and investigators to submit both original research and review articles regarding the following potential topics, but not limited to:
- Measurement of ROS;
- Pathology of brain injuries;
- Traumatic brain injuries;
- Hypoxic-ischemic brain damage;
- Experimental Model of brain injuries;
- Targeted therapy of brain injuries;
- Drug of abuse and ROS;
- Histological diagnosis of brain injuries;
- Epigenetic of brain injuries;
- miRNA and prognosis of neural damages;
- Novel approach and proof of principle in therapy;
- Related quality of life after brain injuries.
Prof. Dr. Vittorio Fineschi
Prof. Dr. Andreas Buettner
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.