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Insulin Resistance and Oxidative Stress in the Brain: What’s New?

Department of Physiology, Medical University of Bialystok, Mickiewicza 2c Str., 15-222 Bialystok, Poland
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 874; https://doi.org/10.3390/ijms20040874
Received: 24 January 2019 / Revised: 12 February 2019 / Accepted: 14 February 2019 / Published: 18 February 2019
(This article belongs to the Special Issue Oxidative Stress and Brain Injury)
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Abstract

The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. We highlight important correlations found so far between brain oxidative stress, ceramide generation, β-amyloid accumulation, as well as neuronal apoptosis in the IR conditions. View Full-Text
Keywords: brain; insulin resistance; oxidative stress; mitochondrial dysfunction brain; insulin resistance; oxidative stress; mitochondrial dysfunction
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Maciejczyk, M.; Żebrowska, E.; Chabowski, A. Insulin Resistance and Oxidative Stress in the Brain: What’s New? Int. J. Mol. Sci. 2019, 20, 874.

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