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Open AccessArticle

Cannabinoid-mediated Modulation of Oxidative Stress and Early Inflammatory Response after Hypoxia–Ischemia

1
Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country (UPV/EHU), 48940 Leioa, Vizcaya, Spain
2
Biocruces Bizkaia Health Research Institute, Cruces University Hospital, 48903 Barakaldo, Bizkaia, Spain
3
GAIKER Centro Tecnológico, Parque Tecnológico, ed. 202, 48230 Zamudio, Bizkaia, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(4), 1283; https://doi.org/10.3390/ijms21041283
Received: 27 November 2019 / Revised: 8 February 2020 / Accepted: 11 February 2020 / Published: 14 February 2020
(This article belongs to the Special Issue Oxidative Stress and Brain Injury)
In the process of neonatal encephalopathy, oxidative stress and neuroinflammation have a prominent role after perinatal asphyxia. With the exception of therapeutic hypothermia, no therapeutic interventions are available in the clinical setting to target either the oxidative stress or inflammation, despite the high prevalence of neurological sequelae of this devastating condition. The endocannabinoid system (ECS), recently recognized as a widespread neuromodulatory system, plays an important role in the development of the central nervous system (CNS). This study aims to evaluate the potential effect of the cannabinoid (CB) agonist WIN 55,212-2 (WIN) on reactive oxygen species (ROS) and early inflammatory cytokine production after hypoxia–ischemia (HI) in fetal lambs. Hypoxic–ischemic animals were subjected to 60 min of HI by partial occlusion of the umbilical cord. A group of lambs received a single dose of 0.01 μg/kg WIN, whereas non-asphyctic animals served as controls. WIN reduced the widespread and notorious increase in inflammatory markers tumor necrosis factor (TNF)-α and interleukin (IL)-1β and IL-6 induced by HI, a modulatory effect not observed for oxidative stress. Our study suggests that treatment with a low dose of WIN can alter the profile of pro-inflammatory cytokines 3 h after HI. View Full-Text
Keywords: Cannabinoid; oxidative stress; inflammation; agonist WIN 55,212-2; hypoxia ischemia; fetal lambs Cannabinoid; oxidative stress; inflammation; agonist WIN 55,212-2; hypoxia ischemia; fetal lambs
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MDPI and ACS Style

Alonso-Alconada, D.; Álvarez, F.J.; Goñi-de-Cerio, F.; Hilario, E.; Álvarez, A. Cannabinoid-mediated Modulation of Oxidative Stress and Early Inflammatory Response after Hypoxia–Ischemia. Int. J. Mol. Sci. 2020, 21, 1283. https://doi.org/10.3390/ijms21041283

AMA Style

Alonso-Alconada D, Álvarez FJ, Goñi-de-Cerio F, Hilario E, Álvarez A. Cannabinoid-mediated Modulation of Oxidative Stress and Early Inflammatory Response after Hypoxia–Ischemia. International Journal of Molecular Sciences. 2020; 21(4):1283. https://doi.org/10.3390/ijms21041283

Chicago/Turabian Style

Alonso-Alconada, Daniel; Álvarez, Francisco J.; Goñi-de-Cerio, Felipe; Hilario, Enrique; Álvarez, Antonia. 2020. "Cannabinoid-mediated Modulation of Oxidative Stress and Early Inflammatory Response after Hypoxia–Ischemia" Int. J. Mol. Sci. 21, no. 4: 1283. https://doi.org/10.3390/ijms21041283

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