Next Article in Journal
Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis
Previous Article in Journal
Membrane Deformation and Its Effects on Flow and Mass Transfer in the Electromembrane Processes
Previous Article in Special Issue
High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus
Article Menu

Article Versions

Export Article

Open AccessReview
Int. J. Mol. Sci. 2019, 20(8), 1841; https://doi.org/10.3390/ijms20081841

Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved

1
Department SAIMLAL, “Sapienza” University of Roma, 00161 Rome, Italy
2
IRCCS “Neuromed” – Neurosurgery Division, 86077 Pozzilli. (IS) Italy
3
NESMOS Department – Neurosurgery Division, “Sapienza” University of Roma, 00189 Rome, Italy
4
Forensic Pathology Institute, University of Foggia, 71122 Foggia, Italy
5
Legal Medicine Division, Ospedale Sant’Andrea, 00189 Rome, Italy
*
Author to whom correspondence should be addressed.
Received: 13 March 2019 / Revised: 6 April 2019 / Accepted: 10 April 2019 / Published: 13 April 2019
(This article belongs to the Special Issue Oxidative Stress and Brain Injury)
PDF [1293 KB, uploaded 13 April 2019]

Abstract

Acute traumatic spinal cord injury (SCI) involves primary and secondary injury mechanisms. The primary mechanism is related to the initial traumatic damage caused by the damaging impact and this damage is irreversible. Secondary mechanisms, which begin as early as a few minutes after the initial trauma, include processes such as spinal cord ischemia, cellular excitotoxicity, ionic dysregulation, and free radical-mediated peroxidation. SCI is featured by different forms of injury, investigating the pathology and degree of clinical diagnosis and treatment strategies, the animal models that have allowed us to better understand this entity and, finally, the role of new diagnostic and prognostic tools such as miRNA could improve our ability to manage this pathological entity. Autopsy could benefit from improvements in miRNA research: the specificity and sensitivity of miRNAs could help physicians in determining the cause of death, besides the time of death.
Keywords: acute spinal cord injury; pathophysiology; clinical management; postmortem techniques; animal models; miRNAs acute spinal cord injury; pathophysiology; clinical management; postmortem techniques; animal models; miRNAs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Pinchi, E.; Frati, A.; Cantatore, S.; D'Errico, S.; Russa, R.L.; Maiese, A.; Palmieri, M.; Pesce, A.; Viola, R.V.; Frati, P.; Fineschi, V. Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved. Int. J. Mol. Sci. 2019, 20, 1841.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top