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Special Issue "Functional Mechanism of B-Vitamins and Their Metabolites"
Deadline for manuscript submissions: closed (30 September 2019).
Dietary recommendations provide guidance on nutrient intakes that afford to fulfil requirements in a specified population. Traditionally, these recommendations were intended to prevent deficiency disorders, but today their aim is extended to the primary prevention of non-communicable diseases, improving the quality of total diet. The B vitamins include a group of eight water-soluble vitamins crucial for a wide range of several metabolic processes in the body. Most B vitamins are excreted quickly from the body with the only exceptions of vitamin B-12 and folate, which are stored in the liver, but folate deficiency is a highly-prevalent vitamin deficiency throughout the world, essentially due scarcity of vegetable food intake. The activity of these two vitamins is particularly crucial for cardiovascular, nervous and brain system function. With ageing the prevalence of age-related diseases and disabilities increases. The maintenance of an optimal nutritional status may contribute to health and wellbeing of the elderly as well as important for public health. Moreover, adequate folate intake is involved in the primary prevention of some congenital anomalies as neural tube and hearth birth defects.
A B-vitamin metabolite, homocysteine (tHcy) plays a key role in two metabolic pathways: remethylation and transsulforation. In the remethylation pathway homocysteine is remethylated to methionine, a reaction catalysed by methionine synthase, which uses vitamin B12 as co-factor and 5-methyltetrahydrofolate (5-MTHF) as a methyl donor. This remethylation takes place in most tissues including liver and kidneys. In the transsulfuration pathway, limited to liver and kidneys, homocysteine is irreversibly converted to cystathionine by cystathionine β-synthase, which requires vitamin B6 as a co-factor.
This Special Issue gives insight in the evolving field of the vitamin B group, as well as its metabolites, regarding mechanisms of action, deficiency, supplementation, health benefits, primary prevention, as well as assessment.
Dr. Elena Azzini
Dr. Stefania Ruggeri
Dr. Angela Polito
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- dietary sources and bioavailability
- preconceptional health promotion
- elderly health
- cardiovascular disease
- frailty and impaired cognitive function