Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells
by
Kathleen Mikkelsen 1
, Monica D. Prakash 1,2, Nyanbol Kuol 1, Kulmira Nurgali 1, Lily Stojanovska 3 and Vasso Apostolopoulos 1,*
Kathleen Mikkelsen 1, Monica D. Prakash 1,2, Nyanbol Kuol 1, Kulmira Nurgali 1, Lily Stojanovska 3 and Vasso Apostolopoulos 1,*
1
Institute for Health and Sport, Victoria University, Werribee Campus, Melbourne, VIC 3030, Australia
2
School of Health and Biomedical Sciences, RMIT University, Bundoora Campus, Melbourne, VIC 3083, Australia
3
College of Food and Agriculture, Department of Nutrition and Health, United Arab Emirates University, Al Ain 16427, UAE
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3763; https://doi.org/10.3390/ijms20153763
Received: 12 June 2019 / Revised: 27 July 2019 / Accepted: 30 July 2019 / Published: 1 August 2019
(This article belongs to the Special Issue Functional Mechanism of B-Vitamins and Their Metabolites)
Chronic inflammation can lead to tumour initiation and progression. Vitamin B complex has the ability to regulate the immune response and, therefore, inflammation but many of the mechanistic and molecular processes involved in this regulation are still not fully understood. This study sought to determine some of these processes by studying the effects of vitamin B2 (riboflavin) B6 (pyridoxine) and B9 (folic acid) on un-differentiated pro-monocytic lymphoma cells in regard to their ability to alter the proliferation, migration, apoptosis, cytokines and expression levels of programmed death ligand 1. We show that vitamin B2, B6 and B9, on pro-monocytic lymphoma cells exerted an anti-tumorigenic effect. This data could form the basis for future studies in using vitamin B supplementation to reduce cancer cell growth in vivo.
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Keywords:
vitamin B complex; pro-monocytes; U937 cell line; riboflavin; pyridoxine; folate; vitamin B2; vitamin B6; vitamin B9
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MDPI and ACS Style
Mikkelsen, K.; Prakash, M.D.; Kuol, N.; Nurgali, K.; Stojanovska, L.; Apostolopoulos, V. Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells. Int. J. Mol. Sci. 2019, 20, 3763.
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