Role of Glutamate Receptors in CNS Diseases

Dear Colleagues,

Glutamate is a fundamental excitatory neurotransmitter in the central nervous system (CNS), and the role of glutamatergic neurotransmission has been established through a long research history, playing key roles in memory, neuronal development, and synaptic plasticity. Glutamate receptors are subdivided into two classes: ionotropic receptors, which act as ion channels (AMPA, NMDA and kainite receptors), and metabotropic receptors (mGluRs), which belong to the GPCRs that modulate cascades of intracellular second messengers. Since receptor dysregulation is involved in a variety of neurological and psychiatric disorders, such as mood disorders, Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and chronic pain, preclinical translational studies are actively required to determine the precise role of glutamate receptors in different pathological scenarios.

This Special Issue aims to collect a selection of research papers and reviews that focus on the role of glutamate receptors in CNS diseases and that will help the scientific community to better understand the underlying molecular pathomechanisms and identify new potential pharmacological targets.

Prof. Ernesto Fedele
Dr. Tiziana Bonifacino
Guest Editors

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